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Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety

Published online by Cambridge University Press:  08 March 2007

Martin O. Weickert*
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Joachim Spranger
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Jens J. Holst
Affiliation:
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark
Bärbel Otto
Affiliation:
Department of Medicine, University Hospital Innenstadt, Ziemssenstrasse 1, 80336 Munich, Germany
Corinna Koebnick
Affiliation:
Department of Preventive Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
Matthias Möhlig
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
Andreas F. H. Pfeiffer
Affiliation:
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 155, 14558 Nuthetal, Germany Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
*
*Corresponding author: Dr Martin O. Weickert, fax +49 33200 88 777, email m.weickert@mail.dife.de
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Abstract

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Weight gain and risk of type 2 diabetes are inversely associated with a high intake of insoluble cereal fibres. Because nutrient-induced changes of ‘satiety hormones’ from the gut may play a role in this process, we evaluated the effects of purified insoluble fibres on postprandial responses of plasma peptide YY (PYY), serum ghrelin and satiety as secondary outcome measures of a study investigating effects of cereal fibres on parameters of glucose metabolism. Fourteen healthy women were studied on six occasions in a randomized, single-blind, controlled crossover design. After 24 h run-in periods and 10 h overnight fasts, subjects ingested isoenergetic and macronutrient matched portions of control white bread or fibre-enriched bread (wheat-fibre or oat-fibre) at 08.15 hours. Gut hormones and hunger scores were measured for 300 min. Basal PYY and ghrelin concentrations were not different between the test meals (P>0·15). Postprandial responses of PYY and ghrelin were blunted after the intake of wheat-fibre (total area under the curve (AUC) PYY, 177·9 (sem 8·1) (pmol/l) min; P=0·016; ghrelin 51·0 (sem 2·5) (pmol/l) min; P=0·003), but not after oat-fibre (PYY 226·7 (sem 25·7) (pmol/l) min; P>0·15; ghrelin 46·2 (sem 1·6) (pmol/l) min; P=0·127), compared to control (PYY 247·5 (sem 25·6) (pmol/l) min; ghrelin 42·5 (sem 1·3) (pmol/l) min). Postprandial hunger scores were unaffected by the different test meals (P>0·15). Thus, oat- and wheat-fibre consumption result in different postprandial responses of PYY and ghrelin, but interestingly do not differ in satiety effects.

Type
Short Communication
Copyright
Copyright © The Nutrition Society 2006

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