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Efficacy and safety of St. John's wort for the treatment of major depression

Published online by Cambridge University Press:  02 January 2007

Monica Nangia ,
Waqar Syed  and
P Murali Doraiswamy
Monica Nangia
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Waqar Syed
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
P Murali Doraiswamy*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
*
*Corresponding author: Email murali@acpub.duke.edu
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Abstract

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Objective

Extracts of St. John's wort have been widely used in the treatment of depression. Our aim was to review information related to the efficacy and safety of St. John's wort as an antidepressant.

Data sources

Primary and review articles were identified by a search of Medline (1960 to February 2000) and through secondary sources.

Study selection

All the articles identified from the data sources were evaluated and all relevant information was included in this review. The pharmacokinetics, mechanism of action, efficacy, side effects and drug interactions of St. John's wort have been examined in various studies.

Conclusion

St. John's wort is a promising investigational antidepressant, but the data are not yet sufficient to accept hypericum as a first line antidepressant preparation for treatment of depression. Besides the need for dose standardization and adequate trial lengths, there is a need for studies in severely depressed patients and long-term studies to assess the risk of relapse and recurrence.

Keywords

HypericumMajor depressionClinical trialsAdverse eventsDrug interactionsHyperforin
Type
Research Article
Information
Public Health Nutrition , Volume 3 , Supplement 4a , December 2000 , pp. 487 - 494
Copyright
Copyright © CABI Publishing 2000

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