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The effects of nutrients on mood

Published online by Cambridge University Press:  02 January 2007

David Benton
Affiliation:
Department of Psychology, University of Wales Swansea, Swansea, SA2 8PP, UK
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Abstract

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A recent major theory was that a meal high in carbohydrate increased the rate that tryptophan enters the brain, leading to an increase in the level of the neurotransmitter serotonin that modulates mood. Although such a mechanism may be important under laboratory conditions it is unlikely to be of significance following the eating of any typical meal. As little as 2–4% of the calories of a meal as protein will prevent an increased availability of tryptophan. Arguably the food with the greatest impact on mood is chocolate. Those who crave chocolate tend to do so when they feel emotionally low. There have been a series of suggestions that chocolate's mood elevating properties reflect ‘drug-like’ constituents including anandamines, caffeine, phenylethylamine and magnesium. However, the levels of these substances are so low as to preclude such influences. As all palatable foods stimulate endorphin release in the brain this is the most likely mechanism to account for the elevation of mood. A deficiency of many vitamins is associated with psychological symptoms. In some elderly patients folate deficiency is associated with depression. In four double-blind studies an improvement in thiamine status was associated with improved mood. Iron deficiency anaemia is common, particularly in women, and is associated with apathy, depression and rapid fatigue when exercising.

Type
Research Article
Copyright
Copyright © CABI Publishing 1999

References

1Wurtman, RJ, Wurtman, JJ. Carbohydrates and depression. Sci. Amer. 1989; 260: 50–7.Google Scholar
2Rosenthal, NE, Genhart, MJ, Caballero, B, Jacobsen, FM, Skwerer, RG, Coursey, RD, Rogers, S, Spring, BJ. Psychobiological effects of carbohydrate- and protein-rich meals in patients with seasonal affective disorder and normal controls. Biol. Psychiat. 1989; 25: 1029–40.Google Scholar
3de Castro, JM. Macronutrient relationships with meal patterns and mood in spontaneous feeding behavior of humans. Physiol. Behav. 1987; 39: 561–9.Google Scholar
4Jansen, A, van den Hout, MA, Griez, E. Does bingeing restore bulimics' alleged 5HT deficiency? Behav. Res. Ther. 1989; 27: 555–60.Google Scholar
5Keith, RE, O'Keefe, KA, Blessing, DL, Wilson, DG. Alternations in dietary carbohydrate, protein and fat intake and mood state in trained females cyclists. Med. Sci. Sports Exer. 1991; 23: 212–6.Google Scholar
6Deijen, JB, Heemstra, ML, Orlebeke, JF. Dietary effects on mood and performance. J. Psychiat. Res. 1989; 23: 275–83.Google Scholar
7Prusaczk, WK, Dishman, RK, Cureton, KJ. No effect of glycogen depleting exercise and altered diet composition on mood state. Med. Sci. Sports Exer. 1992; 24: 708–13.Google Scholar
8Wurtman, RJ, Hefti, F, Melamed, E. Precursor control of neurotransmitters. Pharmacol. Rev. 1981; 32: 315–35.Google Scholar
9Spring, B, Chiodo, J, Bowen, DJ. Carbohydrates tryptophan and behavior: a methodological review. Psychol. Bull. 1987; 102: 234–56.Google Scholar
10Lieberman, HR, Caballero, B, Finer, N. The composition of lunch determines afternoon plasma tryptophan ratios in humans. J. Neural Trans. 1986; 65: 211–7.CrossRefGoogle ScholarPubMed
11Teff, KL, Young, SN, Blundell, JE. The effect of protein or carbohydrate breakfasts on subsequent plasma amino acid levels satiety and nutrient selection in normal males. Pharmacol. Biochem. Behav. 1989; 34: 829–37.CrossRefGoogle ScholarPubMed
12Pijl, H, Koppeschaar, HPF, Cohen, AF, Iestra, JA, Schoemaker, HC, Frolich, M, Onkenhout, W, Meinders, A.E. Evidence for brain serotonin-mediated control of carbohydrate consumption in normal weight and obese humans. Int. J. Obes. 1993; 17: 513–20.Google ScholarPubMed
13Benton, D, Greenfield, K, Morgan, M. The development of the attitudes to chocolate questionnaire. Person. Individ. Diff. 1998; 24: 513–20.Google Scholar
14Hetherington, MM, MacDiarmid, JI. Chocolate addiction: a preliminary study of its description and its relationship to problem eating. Appetite 1993; 21: 233–46.Google Scholar
15Schuman, M, Gitlin, M.J, Fairbanks, L. Sweets chocolate and atypical depressive traits. J. Nerv. Ment. Dis. 1987; 175: 491–5.Google Scholar
16Hill, AJ, Weaver, CFL, Blundell, JE. Food craving, dietary restraint and mood. Appetite 1991; 17: 187–97.Google Scholar
17Lester, D, Bernard, D. Liking for chocolate depression and suicidal preoccupation. Psychol. Rep. 1991; 69: 570.Google Scholar
18Willner, P, Benton, D, Brown, E, Cheeta, S, Davies, G, Morgan, J, Morgan, M. Depression increases craving for sweet rewards in animal and human models of depression and craving. Psychopharmacol. 1998; 136: 272–83.CrossRefGoogle ScholarPubMed
19Benton, D. Chocolate craving: a biological or psychological phenomenon? In: Knight, I, ed. Chocolate and Cocoa: A Review of Health and Nutrition. Oxford: Blackwell Science Limited, 1999: in press.Google Scholar
20DiTomaso, E, Beltramo, M, Piomelli, D. Brain cannabinoids in chocolate. Nature 1996; 382: 677–8.Google Scholar
21Rozin, P, Levine, E, Stoess, C. Chocolate craving and liking. Appetite 1991; 17: 199212.Google Scholar
22Reid, LD. Endogenous opioid peptides and regulation of drinking and feeding. Am. J. Clin. Nutr. 1985; 42: 1099–132.Google Scholar
23Giraudo, SQ, Grace, MK, Welch, CC, Billington, CJ, Levine, AS. Nalxone's anoretic effect is dependent upon the relative palatability of food. Pharmacol. Biochem. Behav. 1993; 46: 917–21.CrossRefGoogle Scholar
24Spiegel, TA, Stunkard, AJ, Shrager, EE, O'Brien, CP, Morrsion, MF. Effect of naltrexone on food intake hunger and satiety in obese humans. Physiol. Behav. 1987; 40: 135–41.Google Scholar
25Wolkowitz, OM, Doran, MR, Cohen, RM, Cohen, TN, Wise, TN, Pickar, D. Single-dose naloxone acutely reduced eating in obese humans: Behavioral and biochemical effects. Biol. Psychiat. 1988; 24: 483–7.CrossRefGoogle ScholarPubMed
26Trenchard, E, Silverstone, T. Naloxone reduces the food intake of normal human volunteers. Appetite 1982; 4: 249–57.Google Scholar
27Yeomans, MR, Wright, P, Macleod, HA, Critchley, JA. Effects of nalmefene on feeding in humans. Psychopharmacol. 1990; 100: 426–32.Google Scholar
28Mandenoff, AF, Fumerton, M, Apfelbaum, M, Margules, DL. Endogenous opiates and energy balance. Science 1982; 215: 1536–7.CrossRefGoogle ScholarPubMed
29Brozek, J. Psychological effects of thiamine restriction and deprivation in normal young men. Am. J. Clin. Nutr. 1957; 5: 109–18.Google Scholar
30Sterner, RT, Price, RW. Restricted riboflavin: within subject behavioral effects in humans. Am. J. Clin. Nutr. 1973; 26: 150–60.Google Scholar
31Kinsman, RH, Hood, J. Some behavioral effects of ascorbic acid deficiency. Am. J. Clin. Nutr. 1971; 24: 455–64.Google Scholar
32Hunter, R, Jones, M, Jones, TG, Matthews, DM. Serum B12 and folate concentrations in mental patients. Brit. J. Psychiat. 1967; 113: 1291–5.CrossRefGoogle Scholar
33Botez, MI, Fontaine, F, Botez, T, Bachevalier, J. Folate-responsive neurological and mental disorders: Report of 16 cases. Eur. Neurol. 1977; 16: 230–46.CrossRefGoogle Scholar
34Carney, MWP, Sheffield, MT. Serum folic acid and B12 in 272 psychiatric inpatients. Psychol. Med. 1978; 8: 139–44.CrossRefGoogle Scholar
35Abou-Saleh, MT, Coppen, C. The biology of folate in depression: implications for nutritional hypotheses of the psychoses. J. Psychiatr. Res. 1986; 20: 91101.Google Scholar
36Hector, M, Burton, JR. What are the psychiatric manifestations of vitamin B12 deficiency? J. Am. Ger. Soc. 1988; 36: 1105–12.CrossRefGoogle ScholarPubMed
37Sommer, BR, Wolkowitz, OM. RBC folic acid levels and cognitive performance in elderly patients: A preliminary report. Biol. Psychiat. 1988; 24: 352–4.Google Scholar
38Shorvon, SD, Carney, MWP, Chanarin, I, Reynolds, H. The neuropsychiatry of megaloblastic anaemia. Br. Med. J. 1980; 281: 1036–8.Google Scholar
39Bell, IR, Edman, JS, Marby, DW, Satlin, A, Dreier, T, Liptzin, B, Cole, JO. Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population. Biol. Psychiat. 1990; 27: 125–37.Google Scholar
40Botez, MI, Botez, T, Maag, U. The Wechsler subtests in mild organic brain damage associated with folate deficiency. Psychol. Med. 1984; 14: 31437.Google Scholar
41Exton-Smith, AN, Scott, DL, eds. Vitamins in the elderly. Bristol: John Wright and Son, 1968.Google Scholar
42Goodwin, JS, Goodwin, J.M, Garry, PJ. Association between nutritional status and cognitive functioning in a healthy elderly population. J. Am. Med. Assoc. 1983; 249: 2917–21.Google Scholar
43Chome, J, Paul, T, Pudel, V, Bleyl, H, Heseker, H, Huppe, R, Kubler, W. Effects of suboptimal vitamin status on behavior. Bibliotheca Nutr. Dieta. 1986; 38: 94104.Google Scholar
44Benton, D, Haller, J, Fordy, J. Vitamin supplementation for one year improves mood. Neuropsychobiol. 1995; 32: 98105.CrossRefGoogle ScholarPubMed
45Smidt, LJ, Cremin, FM, Grivetti, LE, Clifford, AJ. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency. J. Gerontol. 1991; 46: M16M22.CrossRefGoogle ScholarPubMed
46Heseker, H, Kubler, W, Westenhofer, J, Pudel, V. Psychische Veranderungen als Fruhzeichen einer suboptimalen Vitaminversorgung Ernahrungs-Umschau 1990; 37: 8794.Google Scholar
47Benton, D, Griffiths, R, Haller, J. Thiamine supplementation mood and cognitive functioning. Psychopharmacology 1997; 129: 6671.Google Scholar
48Benton, D, Haller, J, Fordy, J. The vitamin status of a sample of young British adults. Int. J. Vit. Nutr. Res. 1997; 67: 3440.Google Scholar
49Benton, D. Vitamin-mineral supplements and intelligence. Proc. Nutr. Soc. 1992; 51: 295302.CrossRefGoogle ScholarPubMed
50Quintas, M, Requejo, AM, Ortega, RM, Redondo, MR, Lopez-Sobaler, AM, Gaspar, MJ. The female Spanish population: a group at risk of nutritional iron deficiency. Int. J. Food Sci. Nutr. 1997; 48: 271–9.Google Scholar
51Milman, N, Clausen, J, Byg, KE. Iron status in 268 Danish women aged 18–30 years: influence of menstruation, contraceptive method and iron supplementation. Ann. Hematol. 1998; 77: 1319.CrossRefGoogle ScholarPubMed
52Fordy, J, Benton, D. Does low iron status influence psychological functioning? J. Human Nutr. Dietet. 1994; 7: 127–33.Google Scholar
53Deakin, V. Iron deficiency in athletes: identification prevention and dietary treatment. In: Burke, L, Deakin, V. eds. Clinical Sports Nutrition. Sydney, McGraw-Hill. 1994.Google Scholar
54Rangan, AM, Blight, GD, Binns, CW. Iron status and non-specific symptoms of female students. J. Amer. Coll. Nutr. 1998; 17: 351–5.Google Scholar
55Nielson, P, Nachtigall, D. Iron supplementation in athletes. Current recommendations. Sports Med. 1998; 26: 207–16.Google Scholar
56Thirlaway, K, Benton, D. Participation in physical activity and cardiovascular fitness have different effects on mental health and mood. J. Psychosom. Res. 1992; 36: 657–65.Google Scholar