Breast Cancer Online

Journal Watch

Basic science: (AUGUST 2007)

Prepared by R Sutherlanda1

a1 Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

(Online publication November 2007)

  • 1. Akli, S, Van Pelt, CS, Bui, TY, Multani, AS, Chang, S, Johnson, D, Tucker, S, Keyomarsi, K. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 2007; 67: 7212–7222. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 2. Almquist, M, Manjer, J, Bondeson, L, Bondeson, AG. Serum calcium, breast cancer risk: results from a prospective cohort study of 7,847 women. Cancer Causes Control 2007; 18: 595–602. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 3. Badve, S, Turbin, D, Thorat, MA, Morimiya, A, Nielsen, TO, Perou, CM, Dunn, S, Huntsman, DG, Nakshatri, H. FOXA1 expression in breast cancer – correlation with luminal subtype A and survival. Clin Cancer Res 2007; 13: 4415–4421. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 4. Bartsch, R, Wenzel, C, Altorjai, G, Pluschnig, U, Mader, RM, Gnant, M, Jakesz, R, Rudas, M, Zielinski, CC, Steger, GG. Her2 and progesterone receptor status are not predictive of response to fulvestrant treatment. Clin Cancer Res 2007; 13: 4435–4439. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 5. Chan, MM, Lu, X, Merchant, FM, Iglehart, JD, Miron, PL. Serial transplantation of NMU-induced rat mammary tumors: a model of human breast cancer progression. Int J Cancer 2007; 121: 474–485. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 6. Dent, R, Trudeau, M, Pritchard, KI, Hanna, WM, Kahn, HK, Sawka, CA, Lickley, LA, Rawlinson, E, Sun, P, Narod, SA. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 2007; 13: 4429–4434. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 7. Drabsch, Y, Hugo, H, Zhang, R, Dowhan, DH, Miao, YR, Gewirtz, AM, Barry, SC, Ramsay, RG, Gonda, TJ. Mechanism of and requirement for estrogen- regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc Natl Acad Sci USA 2007; 104: 13762–13767. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 8. Frankel, LB, Lykkesfeldt, AE, Hansen, JB, Stenvang, J. Protein kinase C α is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells. Breast Cancer Res Treat 2007; 104: 165–179. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 9. Gadir, N, Jackson, DN, Lee, E, Foster, DA. Defective TGF-β signaling sensitizes human cancer cells to rapamycin. Oncogene 2007; 10.1038/sj.onc.1210721. [OpenURL Query Data]  [PubMed]  [Google Scholar]
  • 10. Gatenby, RA, Smallbone, K, Maini, PK, Rose, F, Averill, J, Nagle, RB, Worrall, L, Gillies, RJ. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 2007; 97: 646–653. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 11. Glass, AG, Lacey, JV, Carreon, D, Hoover, RN. Breast cancer incidence, 1980–2006: Combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst 2007; 99: 1152–1161. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 12. Ince, TA, Richardson, AL, Bell, GW, Saitoh, M, Godar, S, Karnoub, AE, Iglehart, JD, Weinberg, RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 2007; 12: 160–170. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 13. Klein, A, Wessel, R, Graessmann, M, Juergens, M, Petersen, I, Schmutzler, R, Niederacher, D, Arnold, N, Meindl, A, Scherneck, S, Seitz, S, Graessmann, A. Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set. Int J Cancer 2007; 121: 683–688. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 14. Kotamraju, S, Willams, CL, Kalyanaraman, B. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer Res 2007; 67: 7386–7394. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 15. Kuo, PL, Chen, CY, Hsu, YL. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res 2007; 67: 7406–7420. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 16. Kuorelahti, A, Rulli, S, Huhtaniemi, I, Poutanen, M. Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGß transgenic female mice present with mammary gland tumors exhibiting characteristics of the wnt/ß-catenin pathway activation. Endocrinology 2007; 148: 3694–3703. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 17. Lahusen, T, Fereshteh, M, Oh, A, Wellstein, A, Riegel, AT. Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1. Cancer Res 2007; 67: 7256–7265. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 18. Lu, D, Sivaprasad, U, Huang, J, Shankar, E, Morrow, S, Basu, A. Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Apoptosis 2007; 12: 1893–1900. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 19. Nangia-Makker, P, Tait, L, Shekhar, MPV, Palomino, E, Hogan, V, Piechocki, MP, Funasaka, T, Raz, A. Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. Int J Cancer 2007; 121: 884–894. [OpenURL Query Data]  [CrossRef]  [Google Scholar]
  • 20. Ntukidem, NI, Nguyen, AT, Stearns, V, Rehman, M, Schott, A, Skaar, T, Jin, Y, Blanche, P, Li, L, Lemler, S, Hayden, J, Krauss, RM, Desta, Z, Flockhart, DA, Hayes, DF. Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen. Clin Pharmacol Ther 2007; 10.1038/sj.clpt.6100343. [OpenURL Query Data]  [PubMed]  [Google Scholar]
  • 21. Razanajaona, D, Joguet, S, Ay, AS, Treilleux, I, Goddard-Leon, S, Bartholin, L, Rimokh, R. Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth. Cancer Res 2007; 67: 7223–7229. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 22. Song, RXD, Zhang, ZG, Chen, YC, Bao, YD, Santen, RJ. Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells. Endocrinology 2007; 148: 4091–4101. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 23. Tamimi, RM, Byrne, C, Colditz, GA, Hankinson, SE. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2007; 99: 1178–1187. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 24. Treszezamsky, AD, Kachnic, LA, Feng, ZH, Zhang, JR, Tokadjian, C, Powell, SN. BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res 2007; 67: 7078–7081. [OpenURL Query Data]  [PubMed]  [CrossRef]  [Google Scholar]
  • 25. Wendt, MK, Cooper, AN, Dwinell, MB. Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells. Oncogene 2007; 110.1038/sj.onc.1210751. [OpenURL Query Data]  [PubMed]  [Google Scholar]
  • 26. Williams, C, Edvardsson, K, Lewandowski, SA, Stroem, A, Gustafsson, JA. A genome-wide study of the repressive effects of estrogen receptor β on estrogen receptor α signaling in breast cancer cells. Oncogene 2007; 10.1038/sj.onc.1210712. [OpenURL Query Data]  [PubMed]  [Google Scholar]
  • 27. Zheng, AP, Kallio, A, Harkonen, P. Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. Endocrinology 2007; 148: 3931–3931. [OpenURL Query Data]  [CrossRef]  [Google Scholar]