British Journal of Nutrition

Full Papers

In appreciation of Sir Philip Randle: The glucose-fatty acid cycle

Mary C. Sugdena1 c1

a1 Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, Whitechapel, London, E1 2AT, UK


The coordinated regulation of metabolic fuel selection is crucial to energy homeostasis. Philip Randle and his colleagues developed the fundamental concept of interplay between carbohydrate and lipid fuels in relation to the requirement for energy utilisation and storage. Their insight has fashioned current understanding of the regulation of metabolism in health and disease, as well as providing a springboard for research into the roles of lipid derivatives in insulin resistance and, at the transcriptional level, lipid-regulated nuclear hormone receptors.


c1 *Corresponding author: Professor Mary C. Sugden, fax 020 7882 2186, email


Abbreviations: FA, fatty acid