British Journal of Nutrition

  • British Journal of Nutrition / Volume 114 / Issue 01 / July 2015, pp 98-107
  • Copyright © The Authors 2015 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • DOI: http://dx.doi.org/10.1017/S0007114515001506 (About DOI), Published online: 25 May 2015
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Full Papers

Human and Clinical Nutrition

Carbohydrate-rich breakfast attenuates glycaemic, insulinaemic and ghrelin response to ad libitum lunch relative to morning fasting in lean adults

Enhad A. Chowdhurya1, Judith D. Richardsona1, Kostas Tsintzasa2, Dylan Thompsona1 and James A. Bettsa1 c1

a1 Department for Health, University of Bath, Bath BA2 7AY, UK

a2 School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK

Abstract

Breakfast omission is associated with obesity and CVD/diabetes, but the acute effects of extended morning fasting upon subsequent energy intake and metabolic/hormonal responses have received less attention. In a randomised cross-over design, thirty-five lean men (n 14) and women (n 21) extended their overnight fast or ingested a typical carbohydrate-rich breakfast in quantities relative to RMR (i.e. 1963 (sd 238) kJ), before an ad libitum lunch 3 h later. Blood samples were obtained hourly throughout the day until 3 h post-lunch, with subjective appetite measures assessed. Lunch intake was greater following extended fasting (640 (sd 1042) kJ, P< 0·01) but incompletely compensated for the omitted breakfast, with total intake lower than the breakfast trial (3887 (sd 1326) v. 5213 (sd 1590) kJ, P< 0·001). Systemic concentrations of peptide tyrosine–tyrosine and leptin were greater during the afternoon following breakfast (both P< 0·05) but neither acylated/total ghrelin concentrations were suppressed by the ad libitum lunch in the breakfast trial, remaining greater than the morning fasting trial throughout the afternoon (all P< 0·05). Insulin concentrations were greater during the afternoon in the morning fasting trial (all P< 0·01). There were no differences between trials in subjective appetite during the afternoon. In conclusion, morning fasting caused incomplete energy compensation at an ad libitum lunch. Breakfast increased some anorectic hormones during the afternoon but paradoxically abolished ghrelin suppression by the second meal. Extending morning fasting until lunch altered subsequent metabolic and hormonal responses but without greater appetite during the afternoon. The present study clarifies the impact of acute breakfast omission and adds novel insights into second-meal metabolism.

(Received January 29 2015)

(Revised March 27 2015)

(Accepted April 09 2015)

(Online publication May 25 2015)

Key Words:

  • Breakfast skipping;
  • Appetite hormones;
  • Insulin sensitivity;
  • Second-meal effect;
  • Energy intake

Correspondence

c1 Corresponding author: Dr J. A. Betts, fax +44 1225 383833, email j.betts@bath.ac.uk

Footnotes

  Abbreviations: EI, energy intake; PYY, peptide tyrosine–tyrosine

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