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Regenerative medicine in otorhinolaryngology

Published online by Cambridge University Press:  24 June 2015

J C R Wormald ,
J M Fishman ,
S Juniat ,
N Tolley  and
M A Birchall
J C R Wormald*
Affiliation:
Department of ENT, St Mary's Hospital, Imperial College Healthcare Trust, London, UK
J M Fishman
Affiliation:
Department of Surgery, UCL Institute of Child Health, London, UK UCL Ear Institute, Royal National Throat, Nose and Ear Hospital, London, UK
S Juniat
Affiliation:
UCL Ear Institute, Royal National Throat, Nose and Ear Hospital, London, UK
N Tolley
Affiliation:
Department of ENT, St Mary's Hospital, Imperial College Healthcare Trust, London, UK
M A Birchall
Affiliation:
UCL Ear Institute, Royal National Throat, Nose and Ear Hospital, London, UK
*
Address for correspondence: Dr Justin C R Wormald, Department of ENT, St Mary's Hospital, Imperial College Healthcare Trust, Praed Street, Paddington, London W2 1NY, UK E-mail: justinwormald@gmail.com
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Abstract

Background:

Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative therapies are now being developed to treat most other diseases within otolaryngology.

Methods and results:

A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.

Conclusion:

The main issues facing research in regenerative surgery are translation of animal model work into human models, increasing stem cell availability so it can be used to further research, and development of better facilities to enable implementation of these advances.

Keywords

Regenerative MedicineStem CellsTissue EngineeringOtorhinolaryngologyOtologyAudiologyLaryngologyRhinologyHead And Neck CancerReconstructive Surgical Procedures
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 8 , August 2015 , pp. 732 - 739
Copyright
Copyright © JLO (1984) Limited 2015 

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