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On the chemical diversity of the prebiotic ocean of early Earth

Published online by Cambridge University Press:  01 December 2014

Carlo Canepa*
Affiliation:
Dipartimento di Chimica, Università di Torino, Via Pietro Giuria 7, 10125 Torino, Italy

Abstract

This work investigates the consequences on the diverse number of chemical species in a pre-biotic terrestrial aqueous environment endowed with an amino acid source induced by the spontaneous build-up of catalytically active polypeptides from amino acid monomers. The assumed probability that a randomly formed polypeptide exhibits catalytic properties is dependent on constraining both the chemical identity and the position of a fraction of the amino acid residues. Within this hypothesis, and using values of the average length n of the catalytic polypeptides about one half of the present-day enzymes, the stationary-state concentration of the catalytically active polypeptides is ≈1030 −1019 M, and the ratio of the concentration of a product of a catalytic process to the initial concentration of the corresponding substrate is predicted to be ≈106−105. Matching the mean life of each catalytic polypeptide to the mean life of its substrate (λ ≈ ω) is only possible by significantly raising the intensity of the source of the amino acid monomers. Under these hypothetical optimal conditions, the mean lives of the catalytic polypeptides and their substrates have values ω−1 ≈ λ−1 ≈10 yr and the asymptotic concentration of each product is of the same order of magnitude as the concentration of the substrate. In all cases the catalytic efficiency necessary to form the active peptides takes the typical values of present-day enzymes.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2014 

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References

Anders, E. (1989). Pre-biotic organic matter from comets and asteroids. Nature 342, 255257.Google Scholar
Bada, J.L. (2004). How life began on Earth: a status report. Earth. Planet. Sci. Lett. 226, 115.Google Scholar
Brack, A. (1993). From amino acids to prebiotic active peptides: a chemical reconstitution. Pure Appl. Chem. 65, 11431151.Google Scholar
Canepa, C. (2013). The role of catalysis on the formation of an active proto-enzyme in the prebiotic aqueous environment. Nat. Sci. 5, 549555.Google Scholar
Chyba, C.F., Thomas, P.J., Brookshaw, L. & Sagan, C. (1990). Cometary delivery of organic molecules to the early earth. Science 249, 366373.Google Scholar
De Ley, J. (1968). Molecular biology and bacterial phylogeny. J. Evol. Biol. 2, 103156.Google Scholar
Gorlero, M., Wieczorek, R., Adamala, K., Giorgi, A., Schininà, M.E., Stano, P. & Luisi, P.L. (2009). Ser-His catalyses the formation of peptides and PNAs. FEBS Lett. 583, 153156.CrossRefGoogle ScholarPubMed
Hartmann, W.K., Ryder, G., Dones, L. & Grinspoon, D. (2000). The Time-dependent Intense Bombardment of the Primordial Earth/Moon System. Origin of the Earth and Moon. University of Arizona Press, Tucson.Google Scholar
Lee, D.H., Granja, J.R., Martinez, J.A., Severin, K. & Ghadiri, M.R. (1996). A self-replicating peptide. Nature 382, 525528.Google Scholar
Matrajt, G., Pizzarello, S., Taylor, S. & Brownlee, D. (2004). Concentration and variability of the AIB amino acid in polar micrometeorites: implications for the exogenous delivery of amino acids to the primitive earth. Meteorit. Planet. Sci. 11, 18491858.Google Scholar
Muñoz Caro, G.M., Meierhenrich, U.J., Schutte, W.A., Barbier, B., Arcones Segovia, A., Rosenbauer, H., Thiemann, W.H-P., Brack, A. & Greenberg, J.M. (2002). Amino acids from ultraviolet irradiation of interstellar ice analogues. Nature 416, 403406.Google Scholar
Radzicka, A. & Wolfenden, R. (1996). Rates of uncatalyzed peptide bond hydrolysis in neutral solution and the transition state affinities of proteases. J. Am. Chem. Soc. 118, 61056109.Google Scholar
Rode, B.M. (1999). Peptides and the origin of life. Peptides 20, 773786.Google Scholar
Thomas, P.J., Hicks, R.D., Chyba, C.F. & McKay, C.P. (2006). Comets and the Origin and Evolution of Life. Springer, Berlin, Heidelberg.Google Scholar
Wilson, R. (2009). Organic material in micrometeorites: processes affecting its delivery to planetary environments. Dissertation, The Open University.Google Scholar