Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-17T10:07:23.243Z Has data issue: false hasContentIssue false
  • English
  • Français

A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

Published online by Cambridge University Press:  19 March 2015

K G Effat  and
M Milad
K G Effat*
Affiliation:
Department of Otolaryngology, El-Sahel Teaching Hospital, Cairo, Egypt
M Milad
Affiliation:
Department of Pathology, Cairo University Hospital, Egypt
*
Address for correspondence:Dr K G Effat, 6 Falaky Square, Cairo, Egypt E-mail: kamaleffat@hotmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.

Methods:

A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.

Results:

Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.

Conclusion:

Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

Keywords

Vocal foldPolypsSmokingHistopathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 5 , May 2015 , pp. 484 - 488
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Rosen, CA, Gartner-Schmidt, J, Hathaway, B, Blacke Simpson, C, Postma, GN, Courey, M et al. A nomenclature paradigm for benign midmembranous vocal fold lesions. Laryngoscope 2012;122:1335–41CrossRefGoogle ScholarPubMed
2Kleinsasser, O. Pathogenesis of vocal cord polyps. Ann Otol Rhinol Laryngol 1982;91:378–81CrossRefGoogle ScholarPubMed
3Kambic, V, Radsel, Z, Zargi, M, Acko, M. Vocal cord polyps: incidence, histology and pathogenesis. J Laryngol Otol 1981;95:609–18CrossRefGoogle ScholarPubMed
4Gunter, HE.Modeling mechanical stresses as a factor in the etiology of benign vocal fold lesions. J Biomech 2004;37:1119–24CrossRefGoogle ScholarPubMed
5Li, NYK, Vodovotz, Y, Kim, KH, Mi, Q, Hebda, PA, Abbott, KV. Biosimulation of acute phonotrauma: an extended model. Laryngoscope 2011;121:2418–28CrossRefGoogle ScholarPubMed
6Martins, RHG, Defaveri, J, Domingues, MAC, de Albuquerque e Silva, R. Vocal polyps: clinical, morphological, and immunohistochemical aspects. J Voice 2011;25:98–106CrossRefGoogle ScholarPubMed
7Gale, N, Zidar, N, Fischinger, J, Kambic, V. Clinical applicability of the Ljubljana classification of epithelial hyperplastic laryngeal lesions. Clin Otolaryngol 2000;25:227–32CrossRefGoogle ScholarPubMed
8Hantzakos, A, Remacle, M, Dikkers, FG, Degols, J-C, Delos, M, Friedrich, G et al. Exudative lesions of Reinke's space: a terminology proposal. Eur Arch Otorhinolaryngol 2009;266:869–78CrossRefGoogle ScholarPubMed
9Banjara, H, Mungutwar, V, Singh, D, Gupta, A. Objective and subjective evaluation of larynx in smokers and non-smokers: a comparative study. Indian J Otolaryngol Head Neck Surg 2014;66(suppl1):S99–S109CrossRefGoogle Scholar
10Dikkers, FG, Nikkels, PGJ. Lamina propria of the mucosa of benign lesions of the vocal folds. Laryngoscope 1999;109:1684–9CrossRefGoogle ScholarPubMed
11Li-jing, M, Jun, W, Yang, X, Jing-ying, Y, Wen, X, Quing-wen, Y. Clinical classification and treatment of leukokeratosis of the vocal cords. Chin Med J 2013;126:3523–7Google Scholar
12Isenberg, JS, Crozier, DL, Dailey, SH. Institutional and comprehensive review of laryngeal leukoplakia. Ann Otol Rhinol Laryngol 2008;117:74–9CrossRefGoogle ScholarPubMed
13Sadri, M, McMahon, J, Parker, A. Laryngeal dysplasia: aetiology and molecular biology. J Laryngol Otol 2006;120:170–7CrossRefGoogle ScholarPubMed
14Smit, CF, Copper, MP, van Leeuwen, JAMJ, Schoots, IG, Stanojcic, LD. Effect of cigarette smoking on gastropharyngeal and gastroesophageal reflux. Ann Otol Rhinol Laryngol 2001;110:190–3CrossRefGoogle ScholarPubMed
15Courey, MS, Shohet, JA, Scott, MA, Ossoff, RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol 1996;105:523–31CrossRefGoogle ScholarPubMed
16Hohberger, L, Wuertz, BRK, Xie, H, Griffin, T, Ondrey, F. TNF-α drives matrix metalloproteinase-9 in squamous oral carcinogenesis. Laryngoscope 2008;118:1395–9CrossRefGoogle ScholarPubMed
17Zhou, L, Xie, M, Zhou, JQ, Tao, L. 67-k Da laminin receptor in human laryngeal squamous cell carcinoma. Laryngoscope 2006;116:28–32CrossRefGoogle Scholar
18Johns, MM. Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg 2003;11:456–61CrossRefGoogle ScholarPubMed
19Altman, KW. Vocal fold masses. Otolaryngol Clin North Am 2007;40:1091–108CrossRefGoogle ScholarPubMed
20Jiang, JJ, Diaz, CE, Hanson, DG. Finite element modeling of vocal fold vibration in normal phonation and hyperfunctional dysphonia: implications for the pathogenesis of vocal nodules. Ann Otol Rhinol Laryngol 1998;107:603–10CrossRefGoogle ScholarPubMed
21Zhang, Y, Jiang, JJ. Chaotic vibrations of a vocal fold model with a unilateral polyp. J Acoust Soc Am 2004;115:1266–9CrossRefGoogle ScholarPubMed
22Wallis, L, Jackson-Menaldi, C, Holland, W, Giraldo, A. Vocal fold nodule vs. vocal fold polyp: answer from surgical pathologist and voice pathologist point of view. J Voice 2004;18:125–9CrossRefGoogle ScholarPubMed
23Cipriani, NA, Martin, DE, Corey, JP, Portugal, L, Caballero, N, Lester, R et al. The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse. Int J Surg Pathol 2011;19:583–7CrossRefGoogle ScholarPubMed
24Walter, JB, Israel, MS. Connective tissue: its normal structure and the effects of disease. In: Walter, JB, Israel, MS, eds. General Pathology, 5th edn.Edinburgh: Churchill Livingstone, 1979;59–70Google Scholar