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Serum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorder

Published online by Cambridge University Press:  20 February 2015

Ibrahim Kaplan ,
Mahmut Bulut ,
Abdullah Atli ,
Mehmet Güneş ,
Mehmet Cemal Kaya  and
Leyla Çolpan
Ibrahim Kaplan*
Affiliation:
Department of Biochemistry, Medical Faculty, Dicle University, Diyarbakır, Turkey
Mahmut Bulut
Affiliation:
Department of Psychiatry, Medical Faculty, Dicle University, Diyarbakır, Turkey
Abdullah Atli
Affiliation:
Department of Psychiatry, Medical Faculty, Dicle University, Diyarbakır, Turkey
Mehmet Güneş
Affiliation:
Department of Psychiatry, Medical Faculty, Dicle University, Diyarbakır, Turkey
Mehmet Cemal Kaya
Affiliation:
Department of Psychiatry, Medical Faculty, Dicle University, Diyarbakır, Turkey
Leyla Çolpan
Affiliation:
Department of Biochemistry, Medical Faculty, Dicle University, Diyarbakır, Turkey
*
Ibrahim Kaplan, Department of Medical Biochemistry, Medical Faculty, Dicle University, Diyarbakır, Turkey. Tel: +90 505 451 2025; Fax: +90 412 248 8520; E-mail: dribrahimkaplan@hotmail.com
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Abstract

Objective

Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein that is widely used as a tumour marker in adenocarcinomas. However, several non-neoplastic conditions, including acute and chronic inflammation and other inflammation-related conditions, are characterised by increased CEA concentrations.

Bipolar disorder (BD) ranks seventh among the worldwide burden of non-fatal diseases. Inflammatory biomarkers have been considered as one of the main key pillars of a multifactorial approach for prediction of BD in an at-risk population.

BP is accompanied by activation of inflammatory, cell-mediated and negative immunoregulatory cytokines.

Methods

We measured the levels of CEA in serum samples from 44 individuals with euthymic BP out-patients and 45 healthy controls. Patients were diagnosed according to the DSM-IV criteria. CEA was measured by an electrochemiluminescence immunoassay.

Results

The mean serum CEA concentration was 2.36±1.52 and 1.77±0.98 µg/l in patients and controls, respectively. CEA levels were significantly increased in euthymic BP patients when compared with controls (p=0.031).

Conclusions

This study suggests that CEA is increased in BD and supports a role for immune activation in the core pathological mechanisms of BP. CEA levels may be a secondary marker for diagnosing BP.

Keywords

bipolar disorderCEAproinflammatory cytokines
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 3 , June 2015 , pp. 177 - 181
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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