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Setaria digitata in advancing our knowledge of human lymphatic filariasis

Published online by Cambridge University Press:  30 April 2015

A.N.I. Perumal ,
Y.I.N.S. Gunawardene  and
R.S. Dassanayake
A.N.I. Perumal
Affiliation:
Department of Chemistry, Faculty of Science, University of Colombo, Sri Lanka
Y.I.N.S. Gunawardene
Affiliation:
Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
R.S. Dassanayake*
Affiliation:
Department of Chemistry, Faculty of Science, University of Colombo, Sri Lanka
*
*Fax: 94-11-2503367 E-mail: rsdassanayake@chem.cmb.ac.lk
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Abstract

Setaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. Due to its close resemblance to Wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. This review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of S. digitata that have broadened our understanding towards the control and eradication of filarial diseases.

Type
Review Article
Information
Journal of Helminthology , Volume 90 , Issue 2 , March 2016 , pp. 129 - 138
Copyright
Copyright © Cambridge University Press 2015 

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