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Bioabsorbable bioadhesive hydrogel comprising poly(acrylic acid) and poly(vinylpyrrolidone) for adhesion barrier and hemostatic device

Published online by Cambridge University Press:  26 March 2015

Tomoko Ito ,
Masazumi Eriguchi  and
Yoshiyuki Koyama
Tomoko Ito*
Affiliation:
Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo 189-0021, Japan
Masazumi Eriguchi
Affiliation:
Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo 189-0021, Japan
Yoshiyuki Koyama
Affiliation:
Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo 189-0021, Japan
*
Address all correspondence to Tomoko Ito attito@shinyamanote.jp
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Abstract

Poly(acrylic acid) (PAA) and poly(vinylpyrrolidone) (PVP) are both highly safe synthetic polymers approved as pharmaceutical excipients. When their aqueous solutions are mixed, insoluble rigid complex is precipitated. On the other hand, if the dried PAA film was immersed in aqueous PVP solution, swollen PAA/PVP soft hydrogel was obtained. Heated drying of the gel afforded a transparent water-swellable film. The swellable PAA/PVP complex film exhibited favorable properties in medical use. If the film was put on a bleeding site, it swelled, and stuck to a hemorrhaging spot, and efficiently arrested bleeding. It could also prevent the adhesion formation by injured intestines.

Type
Research Letters
Information
MRS Communications , Volume 5 , Issue 2 , June 2015 , pp. 291 - 295
Copyright
Copyright © Materials Research Society 2015 

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