Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-18T18:37:58.460Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum soluble tumour necrosis factor related apoptosis-inducing ligand level and peripheral eosinophil count in patients with nasal polyposis

Published online by Cambridge University Press:  06 February 2015

A Bisgin ,
H Eyigor ,
U Osma ,
M D Yilmaz  and
A D Yalcin
A Bisgin*
Affiliation:
Medical Genetics Department of Balcali Clinics and Hospitals, Faculty of Medicine, Cukurova University, Adana, Turkey Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Sweden
H Eyigor
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
U Osma
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
M D Yilmaz
Affiliation:
Department of Otorhinolaryngology, Antalya Training and Research Hospital, Turkey
A D Yalcin
Affiliation:
Department of Internal Medicine, Allergy and Clinical Immunology Unit, Antalya Training and Research Hospital, Turkey Genomics Research Center, Academia Sinica, Taipei, Taiwan
*
Address for correspondence: Dr Atil Bisgin, Medical Genetics Department of Balcali Clinics and Hospitals, Faculty of Medicine, Cukurova University, Adana, Turkey E-mail: abisgin@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. Eosinophilic inflammation plays an important role in the pathogenesis. This study aimed to investigate soluble tumour necrosis factor related apoptosis-inducing ligand levels and eosinophil count in nasal polyposis patients.

Methods:

The study was performed on 24 adult nasal polyposis patients and 24 age-matched healthy individuals. The patients had not received any medical or surgical treatment. Pre-operative computed tomography scans were assessed using the Lund–MacKay grading system, and soluble tumour necrosis factor related apoptosis-inducing ligand levels were measured with a sandwich enzyme-linked immunosorbent assay.

Results:

Compared with controls, eosinophil levels in nasal polyposis patients were increased (p = 0.024), but there was no significant difference in soluble tumour necrosis factor related apoptosis-inducing ligand levels (p = 0.529). The Lund–Mackay mean grading was 12.43 ± 6.9. There was no correlation between soluble tumour necrosis factor related apoptosis-inducing ligand level and Lund–Mackay grading and eosinophil count.

Conclusion:

There was no relationship between soluble tumour necrosis factor related apoptosis-inducing ligand level and blood eosinophil or clinical markers; however, soluble tumour necrosis factor related apoptosis-inducing ligand level remains of interest for future studies.

Keywords

Nasal PolypsEosinophilsBiological Markers
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 3 , March 2015 , pp. 250 - 253
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Newton, JR, Ah-See, KW. A review of nasal polyposis. Ther Clin Risk Manag 2008;4:507–12CrossRefGoogle ScholarPubMed
2Tos, M, Mogensen, C. Pathogenesis of nasal polyps. Rhinology 1977;15:87–95Google Scholar
3Drake-Lee, AB. The pathogenesis of nasal polyps. In: Settipane, GA, Lund, VJ, Bernstein, JM, Tos, M, eds. Nasal Polyps: Epidemiology, Pathogenesis and Treatment. Rhode Island: Ocean Side Publications, 1997;17–64Google Scholar
4Bernstein, JM. Update on the molecular biology of nasal polyposis. Review. Otolaryngol Clin North Am 2005;38:1243–55Google Scholar
5Lanza, L, Scudeletti, M, Puppo, F, Bosco, O, Peirano, L, Filaci, G et al. Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes. Clin Exp Immunol 1996;103:482–90Google Scholar
6Falschlehner, C, Schaefer, U, Walczak, H. Following TRAIL's path in the immune system. Review. Immunology 2009;127:145–54CrossRefGoogle Scholar
7Fang, SY, Yang, BC. Overexpression of Fas-ligand in human nasal polyps. Ann Otol Rhinol Laryngol 2000;109:267–70Google Scholar
8Bisgin, A, Kargi, A, Yalcin, AD, Aydin, C, Ekinci, D, Savas, B et al. Increased serum sTRAIL levels were correlated with patient survival in bevacizumab-treated metastatic colon cancer. BMC Cancer 2012;12:58Google Scholar
9Deftereos, S, Giannopoulos, G, Kossyvakis, C, Kaoukis, A, Raisakis, K, Panagopoulou, V et al. Association of soluble tumour necrosis factor-related apoptosis-inducing ligand levels with coronary plaque burden and composition. Heart 2012;98:214–18CrossRefGoogle ScholarPubMed
10Liabeuf, S, Barreto, DV, Barreto, FC, Chasseraud, M, Brazier, M, Choukroun, G et al. The circulating soluble TRAIL is a negative marker for inflammation inversely associated with the mortality risk in chronic kidney disease patients. Nephrol Dial Transplant 2010;25:2596–602Google Scholar
11Yalcin, AD, Bisgin, A, Kargi, A, Gorczynski, RM. Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to omalizumab treatment. Med Sci Monit 2012;18:PI11–15Google Scholar
12Yalcin, AD, Bisgin, A. The relation of sTRAIL levels and quality of life in severe persistent allergic asthma patients using omalizumab. Med Sci Monit 2012;18:LE9–10Google Scholar
13Bisgin, A, Terzioglu, E, Aydin, C, Yoldas, B, Yazisiz, V, Balci, N et al. TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis. BMC Musculoskelet Disord 2010;11:192Google Scholar
14Shin, JY, Shin, YG, Chung, CH. Elevated serum osteoprotegerin levels are associated with vascular endothelial dysfunction in type 2 diabetes. Diabetes Care 2006;29:1664–6CrossRefGoogle ScholarPubMed
15Bisgin, A, Yalcin, AD, Gorczynski, RM. Circulating soluble tumor necrosis factor related apoptosis inducing-ligand (TRAIL) is decreased in type-2 newly diagnosed, non-drug using diabetic patients. Diabetes Res Clin Pract 2012;96:e84–6Google Scholar
16Chao, SS, Graham, SM, Brown, CL, Kline, JN, Hussain, I. Role of delayed cellular apoptosis in the pathogenesis of nasal polyps. J Allergy Clin Immunol 2004;113:S280Google Scholar
17Poznanovic, SA, Kingdom, TT. Total IgE levels and peripheral eosinophilia correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. Arch Otolaryngol Head Neck Surg 2007;133:701–4Google Scholar
18Perić, A, Vojvodić, D, Radulović, V, Vukomanović-Đurđević, B, Miljanović, O. Correlation between cytokine levels in nasal fluid and eosinophil counts in nasal polyp tissue in asthmatic and non-asthmatic patients. Allergol Immunopathol (Madr) 2011;39:133–9Google Scholar