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A differential susceptibility analysis reveals the “who and how” about adolescents' responses to preventive interventions: Tests of first- and second-generation Gene × Intervention hypotheses

Published online by Cambridge University Press:  02 February 2015

Gene H. Brody ,
Tianyi Yu  and
Steven R. H. Beach
Gene H. Brody*
Affiliation:
University of Georgia
Tianyi Yu
Affiliation:
University of Georgia
Steven R. H. Beach
Affiliation:
University of Georgia
*
Address correspondence and reprint requests to: Gene H. Brody, Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30602-4527; E-mail: gbrody@uga.edu.
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Abstract

This study was designed to investigate a genetic moderation effect of dopamine receptor 4 gene (DRD4) alleles that have seven or more repeats (long alleles) on an intervention to deter drug use among rural African American adolescents in high-risk families. Adolescents (N = 291, M age = 17) were assigned randomly to the Adults in the Making (AIM) program or to a control condition and were followed for 27.5 months. Adolescents provided data on drug use and vulnerability cognitions three times after pretest. Pretest assessments of caregiver depressive symptoms, disruption in the home, and support toward the adolescent were used to construct a family risk index. Adolescents living in high-risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high-risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles. AIM-induced reductions in vulnerability cognitions were responsible for the Family Risk × AIM × DRD4 status drug use prevention effects. These findings support differential susceptibility predictions and imply that prevention effects on genetically susceptible individuals may be underestimated.

Type
Special Section Articles
Information
Development and Psychopathology , Volume 27 , Issue 1: What Works for Whom? Genetic Moderation of Intervention Efficacy , February 2015 , pp. 37 - 49
Copyright
Copyright © Cambridge University Press 2015 

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