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Neuropsychological Performance of Youth with Secondary Attention-Deficit/Hyperactivity Disorder 6- and 12-Months after Traumatic Brain Injury

Published online by Cambridge University Press:  09 December 2014

Tisha J. Ornstein ,
Sanya Sagar ,
Russell J. Schachar ,
Linda Ewing-Cobbs ,
Sandra B. Chapman ,
Maureen Dennis ,
Ann E. Saunders ,
Tony T. Yang ,
Harvey S. Levin  and
Jeffrey E. Max
Tisha J. Ornstein
Affiliation:
Department of Psychology, Ryerson University, Toronto, Canada
Sanya Sagar
Affiliation:
Department of Psychology, Ryerson University, Toronto, Canada
Russell J. Schachar
Affiliation:
Department of Psychiatry, Neurosciences and Mental Health and Brain and Behaviour Program, Research Institute, The Hospital for Sick Children, Toronto, Canada
Linda Ewing-Cobbs
Affiliation:
Department of Pediatrics, University of Texas Health Science Center, Houston, Texas
Sandra B. Chapman
Affiliation:
Center for Brain Health, The University of Texas at Dallas, Dallas, Texas
Maureen Dennis
Affiliation:
Department of Psychology, Brain and Behaviour Program, Research Institute, The Hospital for Sick Children, Toronto, Canada
Ann E. Saunders
Affiliation:
Department of Psychiatry, University of Texas Health Science Center, Houston, Texas
Tony T. Yang
Affiliation:
Department of Psychiatry, University of California, San Francisco, California
Harvey S. Levin
Affiliation:
Department of Physical Medicine and Rehabilitation, Department of Neurosurgery, and Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas
Jeffrey E. Max*
Affiliation:
Department of Psychiatry, University of California, San Diego, and Rady Children’s Hospital, San Diego, California
*
Correspondence and reprint requests to: Jeffrey Max, Rady Children’s Hospital, 3020 Children’s Way, MC 5018, San Diego, CA 92123. E-mail: jmax@ucsd.edu
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Abstract

The present study compared executive dysfunction among children with attention-deficit/hyperactivity disorder (ADHD) after traumatic brain injury (TBI), also called secondary ADHD (S-ADHD), pre-injury ADHD and children with TBI only (i.e., no ADHD). Youth aged 6–16 years admitted for TBI to five trauma centers were enrolled (n=177) and evaluated with a semi-structured psychiatric interview scheduled on three occasions (within 2 weeks of TBI, i.e., baseline assessment for pre-injury status; 6-months and 12-months post-TBI). This permitted the determination of 6- and 12-month post-injury classifications of membership in three mutually exclusive groups (S-ADHD; pre-injury ADHD; TBI-only). Several executive control measures were administered. Unremitted S-ADHD was present in 17/141 (12%) children at the 6-month assessment, and in 14/125 (11%) children at 12-months post-injury. The study found that children with S-ADHD exhibited deficient working memory, attention, and psychomotor speed as compared to children with pre-injury ADHD. Furthermore, the children with S-ADHD and the children with TBI-only were impaired compared to the children with pre-injury ADHD with regard to planning. No group differences related to response inhibition emerged. Age, but not injury severity, gender, or adaptive functioning was related to executive function outcome. Neuropsychological sequelae distinguish among children who develop S-ADHD following TBI and those with TBI only. Moreover, there appears to be a different pattern of executive control performance in those who develop S-ADHD than in children with pre-injury ADHD suggesting that differences exist in the underlying neural mechanisms that define each disorder, underscoring the need to identify targeted treatment interventions. (JINS, 2014, 20, 971–981)

Keywords

Traumatic brain injuryChildrenAdolescentsS-ADHDP-ADHDNeurocognitive function
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 10 , November 2014 , pp. 971 - 981
Copyright
Copyright © The International Neuropsychological Society 2014 

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Footnotes

*

Deceased – formerly affiliated with the Department of Psychology, The Hopsital for Sick Chlidren.

References

American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders. (4th ed.). Washington, DC: American Psychiatric Press.Google Scholar
Anderson, P. (2002). Assessment and development of executive function (EF) during childhood. Child Neuropsychology, 8(2), 71–82.CrossRefGoogle ScholarPubMed
Anderson, P., Anderson, V., & Lajoie, G. (1996). The tower of London test: Validation and standardization for pediatric populatons. The Clinical Neuropsychologist, 10(1), 54–65.CrossRefGoogle Scholar
Anderson, V. A., Anderson, P., Northam, E., Jacobs, R., & Catroppa, C. (2001). Development of executive functions through late childhood and adolescence in an Australian sample. Developmental Neuropsychology, 20(1), 385–406.CrossRefGoogle Scholar
Azouvi, P., Couillet, J., & Leclercq, M. (2004). Divided attention and mental effort after severe traumatic brain injury. Neuropsychologia, 42, 1260–1268.CrossRefGoogle ScholarPubMed
Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychology Bulletin, 121, 65–94.CrossRefGoogle ScholarPubMed
Barkley, R. A., & Fischer, M. (2011). Predicting impairment in major life activities and occupational functioning in hyperactive children as adults: Self-reported executive function (EF) deficits vs. EF tests. Developmental Neuropsychology, 36, 137–161.CrossRefGoogle Scholar
Best, J. R., Miller, P. H., & Jones, L. L. (2009). Executive functions after age 5: Changes and correlates. Developmental Review, 29(3), 180–200.CrossRefGoogle ScholarPubMed
Bloom, D. R., Levin, H. S., Ewing-Cobbs, L., Saunders, A. E., Song, J., Fletcher, J. M., & Kowatch, R. A. (2001). Lifetime and novel psychiatric disorders after pediatric traumatic brain injury. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 572–579.CrossRefGoogle ScholarPubMed
Boyle, M. H., Offord, D. R., Racine, et al. (1996). Identifying thresholds for classifying childhood psychiatric disorders. Issues and Prospects. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1440–1448.CrossRefGoogle ScholarPubMed
Brown, G., Chadwick, O., Shaffer, D., Rutter, M., & Traub, M. (1981). A prospective study of children with head injuries: III. Psychiatric sequelae. Psychological Medicine, 11(1), 63–78.CrossRefGoogle ScholarPubMed
Chapman, S. B., & McKinnon, L. (2000). Discussion of developmental plasticity: Factors affecting cognitive outcome after pediatric traumatic brain injury. Journal of Communication Disorders, 33, 333–344.CrossRefGoogle ScholarPubMed
Dickstein, S. G., Bannon, K., Castellanos, F. X., & Milham, M. P. (2006). The neural correlates of attention deficit hyperactivity disorder: An ALE meta-analysis. Journal of Child Psychology & Psychiatry, 47, 1051–1062.CrossRefGoogle ScholarPubMed
Fenwick, T., & Anderson, V. (1999). Impairments of attention following childhood traumatic brain injury. Child Neuropsychology, 5, 213–223.CrossRefGoogle ScholarPubMed
Helton, W. S., & Russell, P. N. (2011). Working memory load and the vigilance decrement. Experimental Brain Research, 212, 429–437.CrossRefGoogle ScholarPubMed
Hinshaw, S. P., Carte, E. T., Fan, C., Jassy, J. S., & Owens, E. B. (2007). Neuropsychological functioning of girls with attention-deficit/hyperactivity disorder followed prospectively into adolescence: Evidence for continuing deficits? Neuropsychology, 21, 263–273.CrossRefGoogle ScholarPubMed
Hiscock, Kinsbourne, Samuels, & Krause, (1987). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.Google Scholar
Hollingshead, A. (1975). Four factor index of social status. New Haven, CT: Yale University, Department of Sociology.Google Scholar
Horton, A. M., Soper, H. V., & Reynolds, C. R. (2010). Executive functions in children with traumatic brain injury. Applied Neuropsychology, 17, 99–103.CrossRefGoogle ScholarPubMed
Hyder, A. A., Wunderlich, C. A., Puvanachandra, P., Gururaj, G., & Kobusingye, O. C. (2007). The impact of traumatic brain injuries: A global perspective. Neurorehabilitation, 22, 341–353.CrossRefGoogle ScholarPubMed
Gerring, J., Brandy, K., Chen, A., Quinn, C., Herskovits, E., Bandeen-Roche, K., & Bryan, R. N. (2000). Neuroimaging variables related to development of secondary attention deficit hyperactivity disorder after closed head injury in children and adolescents. Brain Injury, 14, 205–218.Google ScholarPubMed
Gerring, J. P., Brady, K. D., Chen, A., Vasa, R., Grados, M., Bandeen-Roche, K. J., & Denckla, M. B. (1998). Premorbid prevalence of ADHD and development of secondary ADHD after closed head injury. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 647–654.CrossRefGoogle ScholarPubMed
Ginstfeldt, T., & Emanuelson, I. (2010). An overview of attention deficits after paediatric traumatic brain injury. Brain Injury, 24, 1123–1134.CrossRefGoogle ScholarPubMed
Gopin, C. B., & Healey, D. M. (2011). The neural and neurocognitive determinants of ADHD. Journal of Infant, Child, and Adolescent Psychotherapy, 10, 13–31.CrossRefGoogle Scholar
Jaffe, K. M., Polissar, N. L., Fay, G. C., & Liao, S. (1995). Recovery trends over three years following pediatric traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 76, 17–26.CrossRefGoogle ScholarPubMed
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., & Ryan, N. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980–988.CrossRefGoogle ScholarPubMed
Konrad, K., Gauggel, S., Manz, A., & Scholl, M. (2000). Inhibitory control in children with traumatic brain injury (TBI) and children and attention deficit/hyperactivity disorder (ADHD). Brain Injury, 14, 859–875.Google ScholarPubMed
Klorman, R., Hazel-Fernandez, L. A., Shaywitz, S. E., Fletcher, J. M., Marchione, K. E., Holahan, J. M., & Shaywitz, B. A. (1999). Executive functioning deficits in attention-deficit/hyperactivity disorder are independent of oppositional defiant or reading disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 1148–1155.CrossRefGoogle ScholarPubMed
Lajiness-O’Neill, R., Erdodi, E., & Bigler, E. D. (2010). Memory and learning in pediatric traumatic brain injury: A review and examination of moderators of outcome. Applied Neuropsychology, 17, 83–92.CrossRefGoogle ScholarPubMed
Leblanc, N., Chen, S., Swank, P. R., Ewing-Cobbs, L., Barnes, M., Dennis, M., & Schachar, R. (2005). Response inhibition after traumatic brain injury (TBI) in children: Impairment and recovery. Developmental Neuropsychology, 28, 829–848.CrossRefGoogle ScholarPubMed
Leckman, J. F., Sholomskas, D., Thompson, D., Belanger, A., & Weissman, M. M. (1982). Best estimate of lifetime psychiatric diagnosis: A methodological study. Archives of General Psychiatry, 39(8), 879–883.CrossRefGoogle ScholarPubMed
Levin, H. S., Hanten, G., Chang, C-C., Zhang, L., Schachar, R., Ewing-Cobbs, L., & Max, J. E. (2002). Working memory after traumatic brain injury in children. Annuals of Neurology, 52, 82–88.CrossRefGoogle ScholarPubMed
Levin, H., Hanten, G., Max, J., Li, X., Swank, P., Ewing-Cobbs, L., & Schachar, R. (2007). Symptoms of attention-deficit/hyperactivity disorder following traumatic brain injury in children. Journal of Developmental & Behavioral Pediatrics, 28(2), 108–118.CrossRefGoogle ScholarPubMed
Levin, H. S., Hanten, G., Zhang, L., Swank, P. R., & Hunter, J. (2004). Selective impairment of inhibition after TBI in children. Journal of Clinical & Experimental Neuropsychology, 26, 589–597.CrossRefGoogle ScholarPubMed
Levin, H. S., Song, J., Scheibel, R. S., Fletcher, J. M., Harward, H., Lilly, M. M., & Goldstein, F. (1997). Concept formation and problem-solving following closed head injury in children. Journal of the International Neuropsychological Society, 3, 598–607.CrossRefGoogle ScholarPubMed
Levin, H. S., Wilde, E. A., et al. (2008). Diffusion tensor imaging in relation to cognitive and functional outcome of traumatic brain injury in children. Journal of Head Trauma Rehabilitation, 23, 197–208.CrossRefGoogle ScholarPubMed
Logan, G. D. (1994). On the ability to inhibit thought and action: A users’ guide to the stop signal paradigm. In D. D. Dagenbach & T.H. Carr (Eds.), Inhibitory processes in attention, memory, and language (pp. 189–239). San Diego: Academic Press.Google Scholar
Max, J. E., Arndt, S., Castillo, C. S., Bokura, H., Robin, D. A., Lindgren, S. D., & Mattheis, P. J. (1998). Attention-deficit hyperactivity symptomatology after traumatic brain injury: A prospective study. Journal of the American Academy of Child & Adolescent Psychiatry, 37, 841–847.CrossRefGoogle ScholarPubMed
Max, J. E., Lansing, A. E., Koele, S. L., Castillo, C. C., Bokura, H., Schachar, R., & Williams, K. E. (2004). Attention deficit hyperactivity disorder in children and adolescents following traumatic brain injury. Developmental Neuropsychology, 25, 159–177.CrossRefGoogle ScholarPubMed
Max, J. E., Robin, D. A., Lindgren, S. D., Smith, W. L. Jr., Sato, Y., Mattheis, P. J., & Castillo, C. S. (1997). Traumatic brain injury in children and adolescents: Psychiatric disorders at two years. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1278–1285.CrossRefGoogle ScholarPubMed
Max, J. E., Schachar, R., Levin, H. S., Ewing-Cobbs, L., Chapman, S. B., Dennis, M., & Landis, J. (2005). Predictors of attention-deficit/hyperactivity disorder within six months after traumatic brain injury. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 1032–1040.CrossRefGoogle Scholar
Ornstein, T. J., Max, J. E., Schachar, R., Dennis, M., Barnes, M., Ewing-Cobbs, L., & Levin, H. S. (2013). Response inhibition in children with and without ADHD after traumatic brain injury. Journal of Neuropsychology, 7, 1–11.CrossRefGoogle ScholarPubMed
Park, N. W., Moscovitch, M., & Robertson, I. H. (1999). Divided attention impairments after traumatic brain injury. Neuropsychologia, 37(10), 1119–1133.CrossRefGoogle ScholarPubMed
Pennington, B. F., & Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology & Psychiatry, 37, 51–87.CrossRefGoogle ScholarPubMed
Robin, D. A., Max, J. E., Stierwalt, J. A., Guenzer, L. C., & Lindgren, S. D. (1999). Sustained attention in children and adolescents with traumatic brain injury. Aphasiology, 13(9-11), 701–708.CrossRefGoogle Scholar
Schachar, R., Levin, H. S., Max, J. E., Purvis, K., & Chen, S. (2004). Attention deficit hyperactivity disorder symptoms and response inhibition after closed head injury in children: Do preinjury behavior and injury severity predict outcome? Developmental Neuropsychology, 25, 179–198.CrossRefGoogle ScholarPubMed
Schachar, R., Mota, V., Logan, G., Tannock, R., & Klim, P. (2000). Confirmation of an inhibitory control deficit in attention-deficit/ hyperactivity disorder. Journal of Abnormal Child Psychology, 28, 227–235.CrossRefGoogle ScholarPubMed
Schwartz, L., Taylor, H. G., Drotar, D., Yeates, K. O., Wade, S. L., & Stancin, T. (2003). Long-term behavior problems following pediatric traumatic brain injury: Prevalence, predictors, and correlates. Journal of Pediatric Psychology, 28(4), 251–263.CrossRefGoogle ScholarPubMed
Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences, 298, 199–209.Google ScholarPubMed
Shum, D., Gill, H., Banks, M., Maujean, A., Griffin, J., & Ward, H. (2009). Planning ability following moderate to severe traumatic brain injury: Performance on a 4-disk version of the Tower of London. Brain Impairment, 10(03), 320–324.CrossRefGoogle Scholar
Sinopoli, K. J., Schachar, R., & Dennis, M. (2011). Traumatic brain injury and secondary attention deficit/hyperactivity disorder in children and adolescents: The effect of reward on inhibitory control. Journal of Clinical and Experimental Neuropsychology, 33, 805–819.CrossRefGoogle ScholarPubMed
Slomine, B. S., Salorio, C. F., Grados, M. A., Vasa, R. A., Christensen, J. R., & Gering, J. P. (2005). Differences in attention, executive functioning, and memory in children with and without ADHD after severe traumatic brain injury. Journal of the International Neuropsychological Society, 11, 645–653.CrossRefGoogle ScholarPubMed
Sparrow, S., Balla, D., & Cicchetti, D. (1984). The Vineland Adaptive Behavior Scales. Circle Pines, MN: American Guidance Services.Google Scholar
Taylor, H. G. (2004). Research on outcomes of pediatric traumatic brain injury: Current advances and future directions. Developmental Neuropsychology, 25, 199–225.CrossRefGoogle ScholarPubMed
Taylor, G. H., & Alden, J. (1997). Age-related differences in outcomes following childhood brain insults: An introduction and overview. Journal of the International Neuropsychological Society, 3, 555–567.CrossRefGoogle ScholarPubMed
Teasdale, G., & Jennett, B. (1974). Assessment of coma and impaired consciousness. A practical scale. Lancet, 2, 81–84.CrossRefGoogle ScholarPubMed
Thorell, L. B. (2007). Do delay aversion and executive function deficits make distinct contributions to the functional impact of ADHD symptoms? A study of early academic skill deficits. Journal of Child Psychology and Psychiatry, 48(11), 1061–1070.CrossRefGoogle Scholar
Travis, F. (1998). Cortical and cognitive development in 4th, 8th, and 12th grade students: The contribution of speed of processing and executive functioning to cognitive development. Biological Psychology, 48(1), 37–56.CrossRefGoogle ScholarPubMed
Wassenberg, R., Max, J. E., Koele, S. L., & Firme, K. (2004). Classifying psychiatric disorders after traumatic brain injury and orthopaedic injury in children: Adequacy of K-SADS versus CBCL. Brain Injury, 18(4), 377–390.CrossRefGoogle ScholarPubMed
Wassenberg, R., Max, J. E., Lindgren, S. D., & Schatz, A. (2004). Sustained attention in children and adolescents after traumatic brain injury: Relation to severity of injury, adaptive functioning, ADHD and social background. Brain Injury, 18(8), 751–764.CrossRefGoogle ScholarPubMed
Wechsler, D. (1997). WAIS-III administration and scoring manual. San Antonio, TX: The Psychological Corporation.Google Scholar
Welsh, M. C. (1991). Rule-guided behavior and self-monitoring on the Tower of Hanoi disk-transfer task. Cognitive Development, 6(1), 59–76.CrossRefGoogle Scholar
Yeates, O. K., Taylor, H. G., Wade, S. L., Drotar, D., Stancin, T., & Minich, N. (2002). A prospective study of short- and long-term neuropsychological outcomes after traumatic brain injury in children. Neuropsychology, 16, 514–523.CrossRefGoogle Scholar