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Magnetic nanoparticles for magnetically guided therapies against neural diseases

Published online by Cambridge University Press:  13 November 2014

G.F. Goya ,
M.P. Calatayud ,
B. Sanz ,
M. Giannaccini ,
V. Raffa ,
T.E. Torres  and
M.R. Ibarra
G.F. Goya
Affiliation:
Institute of Nanoscience of Aragón, Universidad de Zaragoza, Spain; goya@unizar.es
M.P. Calatayud
Affiliation:
Institute of Nanoscience of Aragón, Universidad de Zaragoza, Spain; pilarcs@unizar.es
B. Sanz
Affiliation:
Institute of Nanoscience of Aragón, Universidad de Zaragoza, Spain; beasanz@unizar.es
M. Giannaccini
Affiliation:
Scuola Superiore Sant’Anna, Italy; m.giannaccini@sssup.it
V. Raffa
Affiliation:
Dipartimento di Biologia, Università di Pisa, Italy; vittoria.raffa@unipi.it
T.E. Torres
Affiliation:
Institute of Nanoscience of Aragón and Laboratory of Advanced Microscopies, University of Zaragoza; teo@unizar.es
M.R. Ibarra
Affiliation:
Institute of Nanoscience of Aragón and Laboratory of Advanced Microscopies, University of Zaragoza; Ibarra@unizar.es
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Abstract

Neurological pathologies and nerve damage are two problems of significant medical and economic impact because of the hurdles of losing nerve functionality in addition to significant mortality and morbidity, and demanding rehabilitation. There are currently a number of examples of how nanotechnology can provide new solutions for biomedical problems. Current strategies for nerve repair rely on the use of functionalized scaffolds working as “nerve guidance channels” to improve axonal regeneration and to direct axonal re-growth across the nerve lesion site. Since low invasiveness and high selectivity of the growth stimulation are usually conflicting requirements, new approaches are being pursued in order to overcome such limitations. Engineered magnetic nanoparticles (MNPs) have emerged from this need for noninvasive therapies for both positioning and guiding neural cells in response to an external magnetic field. Here, we review the current state of the use of MNPs for neuroprotective and magnetically guided therapies. We discuss some conceivable outcomes of current magnetically driven strategies seeking integrated platforms for regenerative action on damaged tissues.

Keywords

Magnetic propertiesbiomaterialnanoscale
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 11: Biological Interactions of Oxide Nanoparticles: The Good and The Evil , November 2014 , pp. 965 - 969
Copyright
Copyright © Materials Research Society 2014 

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