Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-23T10:02:49.668Z Has data issue: false hasContentIssue false
  • English
  • Français

Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case–control study of 26 patients

Published online by Cambridge University Press:  17 September 2014

H Hanakawa ,
Y Orita ,
Y Sato ,
M Takeuchi ,
S Takao ,
K Ohno ,
T Kohno ,
N Iwaki ,
H Marunaka  and
R Tamamura
...Show all authors
H Hanakawa
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Y Orita*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Y Sato
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
M Takeuchi
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
S Takao
Affiliation:
Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
K Ohno
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
T Kohno
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
N Iwaki
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
H Marunaka
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama Medical Center, Japan
R Tamamura
Affiliation:
Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
M Nishibori
Affiliation:
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
H Nagatsuka
Affiliation:
Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
K Nishizaki
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
T Yoshino
Affiliation:
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
*
Address for correspondence: Dr Yorihisa Orita, Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, 700-8558 Okayama, Japan Fax: (+81)-86-235-7308 E-mail: y.orita@live.jp
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion.

Methods:

A case–control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated.

Results:

Results for HMGB1 were dichotomised into positive staining scores (score, 5–7) and negative scores (0–4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6–26.5) after adjusting for other factors.

Conclusion:

In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.

Keywords

HMGB1TongueCarcinomaMetastasis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 10 , October 2014 , pp. 926 - 931
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented at the 37th annual meeting of the Japan Head and Neck Cancer Society, 13–14 June 2013, Tokyo, Japan.

References

1Okamoto, M, Nishimine, M, Kishi, M, Kirita, T, Sugimura, M, Nakamura, M et al. Prediction of delayed neck metastasis in patients with stage I/II squamous cell carcinoma of the tongue. J Oral Pathol Med 2002;31:227–33Google Scholar
2Preis, M, Hadar, T, Soudry, E, Shpitzer, T, Strenov, Y, Hod, R et al. Early tongue carcinoma: analysis of failure. Head Neck 2012;34:418–21Google Scholar
3Yoshimoto, S, Hasegawa, Y, Matsuzuka, T, Shiotani, A, Takahashi, K, Kohno, N et al. Sentinel node biopsy for oral and laryngopharyngeal squamous cell carcinoma: a retrospective study of 177 patients in Japan. Auris Nasus Larynx 2012;39:65–70CrossRefGoogle ScholarPubMed
4Iype, EM, Sebastian, P, Mathew, A, Balagopal, PG, Varghese, BT, Thomas, S. The role of selective neck dissection (I-III) in the treatment of node negative (N0) neck in oral cancer. Oral Oncol 2008;44:1134–8Google Scholar
5Fukano, H, Matsuura, H, Hasegawa, Y, Nakamura, S. Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma. Head Neck 1007;19:205–103.0.CO;2-6>CrossRefGoogle Scholar
6Spiro, RH, Huvos, AG, Wong, GY, Spiro, JD, Gnecco, CA, Strong, EW. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg 1986;152:345–50CrossRefGoogle Scholar
7Keski-Säntti, H, Atula, T, Tikka, J, Hollmen, J, Mäkitie, AA, Leivo, I. Predictive value of histopathologic parameters in early squamous cell carcinoma of oral tongue. Oral Oncol 2007;43:1007–13Google Scholar
8Goerkem, M, Braun, J, Stoeckli, SJ. Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinoma of the oral cavity. Ann Surg Oncol 2010;17:527–35Google Scholar
9Fages, C, Nolo, R, Huttunen, HJ, Eskelinen, E, Rauvala, H. Regulation of cell migration by amphoterin. J Cell Sci 2000;113:611–20Google Scholar
10Taguchi, A, Blood, DC, del Toro, G, Canet, A, Lee, DC, Qu, W et al. Blockade of RAGE-amphoterin signaling suppresses tumour growth and metastases. Nature 2000;405:354–60CrossRefGoogle ScholarPubMed
11Terada, C, Yoshida, A, Nasu, Y, Mori, S, Tomono, Y, Tanaka, M et al. Gene expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic cartilage. Acta Med Okayama 2011;65:369–77Google Scholar
12Wu, D, Ding, Y, Wang, S, Zhang, Q, Liu, L. Increased expression of high mobility group box 1 (HMGB1) is associated with progression and poor prognosis in human nasopharyngeal carcinoma. J Pathol 2008;216:167–75CrossRefGoogle ScholarPubMed
13Liu, Y, Xie, C, Zhang, X, Huang, D, Zhou, X, Tan, P et al. Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance. Eur J Cancer 2010;46:3007–15Google Scholar
14Chuangui, C, Peng, T, Zhentao, Y. The expression of high mobility group box 1 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. Pathol Oncol Res 2012;18:1021–7Google Scholar
15Sasahira, T, Kirita, T, Oue, N, Bhawal, UK, Yamamoto, K, Fujii, K et al. High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma. Cancer Sci 2008;99:1806–12CrossRefGoogle ScholarPubMed
16Maddox, WA, Urist, MM. Histopathological prognostic factors of certain primary oral cavity cancers. Oncology 1990;4:39–42Google Scholar
17Garavello, W, Spreafico, R, Somigliana, E, Gaini, L, Pignataro, L, Gaini, RM. Prognostic influence of gender in patients with oral tongue cancer. Otolaryngol Head Neck Surg 2008;138:768–71Google Scholar
18El-Husseiny, G, Kandil, A, Jamshed, A, Khafaga, Y, Saleem, M, Allam, A et al. Squamous cell carcinoma of the oral tongue: an analysis of prognostic factors. Br J Oral Maxillofac Surg 2000;38:193–9CrossRefGoogle ScholarPubMed
19Chung, HW, Lee, SG, Kim, H, Hong, DJ, Chung, JB, Stroncek, D et al. Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer. J Transl Med 2009;7:38Google Scholar