a1 Holo-Analysis Services Ltd, 66 Bathgate Road, London, SW19 5PH, UK
This exploratory holo-analysis of the efficacy of Bio-Mos®, (BM), an outer cell wall derivative of a strain of Saccharomyces cerevisiae, is part of an empirical modelling research programme comparing the efficacies of potential replacements for veterinary prescription-free pronutrient antibiotics in pig production. The data resource was mined from 128 saccharide publications of which 31/97 on BM (1997 to 2003) provided 69 negatively controlled start-to-finish tests from 10 countries (USA 71%) using 3778 pigs(30·5 per treatment). Respective food intake, live-weight gain and food conversion responses of 0·0075 kg/day (0·99%), 0·0145 kg/day (3·58%) and −0·0526 (3·07%) have coefficients of variation of 511, 163 and 229% and beneficial gain and conversion frequencies of 73 and 68%, 54% jointly. Holo-analytical multiple regression models of BM food intake, live-weight gain and food conversion effects using conventional and less stringent probabilities contain significant independent variables for negative control performances, dosage, discontinuous dosage, test duration, year of test, non-USA test, male, grower-finisher, slatted floor, processed food, antibacterial foods, animal protein food, main vegetable protein not soya bean, added oil/fat food and factorial data, which account for 11 to 68% of variations in response. The models quantify differences in research and praxis and indicate areas for future modelling research on BM dose-response relations, effects of ration ingredient and nutrient contents, other saccharide efficacy comparisons, including lactose, and BM comparisons and interactions with other proposed antibiotic replacements.
(Received November 28 2005)
(Accepted May 19 2006)