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MODELLING OF RESISTIVE PULSE SENSING: FLEXIBLE METHODS FOR SUBMICRON PARTICLES

Part of: General models, approaches, and methods

Published online by Cambridge University Press:  06 June 2014

G. R. WILLMOTT  and
B. G. SMITH
G. R. WILLMOTT*
Affiliation:
The MacDiarmid Institute for Advanced Materials and Nanotechnology, Callaghan Innovation, PO Box 31310, Lower Hutt 5040, New Zealand
B. G. SMITH
Affiliation:
Callaghan Innovation, PO Box 2225, Auckland 1140, New Zealand email bryan.smith@callaghaninnovation.govt.nz
*
✉g.willmott@auckland.ac.nz
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Abstract

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Nanopore science, the study of individual nanoscale pores within thin membranes, is a fast-growing field which presents numerous interesting problems for physicists and applied mathematicians. Nanopores are most commonly applied to resistive pulse sensing (RPS) of individual particles suspended in aqueous electrolyte. The form of a resistive pulse is dependent on an array of experimental variables, including electrolyte characteristics, electrophoretic and convective transport, and (especially) pore and particle geometry. The level of analysis required depends on the application, but any broadly useful approach should be simple and flexible, due to the requirement for high data throughput and variations between different experimental systems and specimens. Here we review analytic methods for interpreting RPS experiments for particles in the approximate range 100 nm to 1 $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}\mu $m, focusing on calculation of resistance change as a function of the particle’s position. We detail a recently developed semi-analytical model and compare the modelled electric field with finite element results. The model can also be used to calculate particle motion, so that the experimental current–time history can be reconstructed. This approach is useful for a wide range of pore and particle geometries, and includes consideration of entrance effects. Tunable elastomeric pores with truncated linear cone geometry are used as a model system.

Keywords

nanoporeresistive pulse sensingtunable pore

MSC classification

Secondary: 70G99: None of the above, but in this section
Type
Research Article
Information
The ANZIAM Journal , Volume 55 , Issue 3 , January 2014 , pp. 197 - 213
Copyright
Copyright © 2014 Australian Mathematical Society 

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