Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-23T19:41:42.528Z Has data issue: false hasContentIssue false
  • English
  • Français

Beyond Consent in Research

Revisiting Vulnerability in Deep Brain Stimulation for Psychiatric Disorders

Published online by Cambridge University Press:  27 May 2014

EMILY BELL ,
ERIC RACINE ,
PAULA CHIASSON ,
MAYA DUFOURCQ-BRANA ,
LAURA B. DUNN ,
JOSEPH J. FINS ,
PAUL J. FORD ,
WALTER GLANNON ,
NIR LIPSMAN  and
MARY ELLEN MACDONALD
...Show all authors
Get access Rights & Permissions [Opens in a new window]

Extract

Neuroethics Now welcomes papers addressing the ethical application of neuroscience in research and patient care, as well as its impact on society.

Keywords

vulnerabilityinformed consentresearchdeep brain stimulationpsychiatryneuroethics
Type
Neuroethics Now
Information
Cambridge Quarterly of Healthcare Ethics , Volume 23 , Issue 3 , July 2014 , pp. 361 - 368
Copyright
Copyright © Cambridge University Press 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Notes

1. Rosenstein, DL, Miller, FG. Ethical considerations in psychopharmacological research involving decisionally impaired subjects. Psychopharmacology (Berl) 2003;171(1):92–7.Google Scholar

2. Goodman, WK, Alterman, RL. Deep brain stimulation for intractable psychiatric disorders. Annual Review of Medicine 2012;63:511–24.Google Scholar

3. Bell, E, Mathieu, G, Racine, E. Preparing the ethical future of deep brain stimulation. Surgical Neurology 2009;72(6):577–86.CrossRefGoogle ScholarPubMed

4. Bell, E, Racine, E. Ethical guidance for the use of deep brain stimulation in psychiatric trials and emerging uses: Review and reflections. In: Denys, D, Feenstra, M, Schuurman, R, eds. Deep Brain Stimulation: A New Frontier in Psychiatry. New York: Springer; 2012:273–88.Google Scholar

5. Dunn, LB, Holtzheimer, PE, Hoop, JG, Mayberg, HS, Weiss Roberts, L, Appelbaum, P. Ethical issues in deep brain stimulation research for treatment-resistant depression: Focus on risk and consent. American Journal of Bioethics 2011;2(1):29–36.Google ScholarPubMed

6. Glannon, W. Consent to deep brain stimulation for neurological and psychiatric disorders. Journal of Clinical Ethics 2010;21(2):104–11.Google Scholar

7. Ford, PJ. Neurosurgical implants: Clinical protocol considerations. Cambridge Quarterly of Healthcare Ethics 2007;16(3):308–11.Google Scholar

8. Fins, JJ, Rezai, AR, Greenberg, BD. Psychosurgery: Avoiding an ethical redux while advancing a therapeutic future. Neurosurgery 2006;59(4):713–6.CrossRefGoogle ScholarPubMed

9. Rabins, P, Appleby, BS, Brandt, J, DeLong, MR, Dunn, LB, Gabriels, L, et al. Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought. Archives of General Psychiatry 2009;66(9):931–7.Google Scholar

10. Nickel, PJ. Vulnerable populations in research: The case of the seriously ill. Theoretical Medicine and Bioethics 2006;27(3):245–64.CrossRefGoogle ScholarPubMed

11. Cohen, BJ, McGarvey, EL, Pinkerton, RC, Kryzhanivska, L. Willingness and competence of depressed and schizophrenic inpatients to consent to research. Journal of the American Academy of Psychiatry and the Law 2004;32(2):134–43.Google ScholarPubMed

12. Appelbaum, PS, Grisso, T, Frank, E, O’Donnell, S, Kupfer, DJ. Competence of depressed patients for consent to research. American Journal of Psychiatry 1999;156(9):1380–4.CrossRefGoogle ScholarPubMed

13. Okai, D, Owen, DG, McGuire, H, Singh, S, Churchill, R, Hotopf, M. Mental capacity in psychiatric patients: Systematic review. British Journal of Psychiatry 2007;191:291–7.CrossRefGoogle ScholarPubMed

14. Ford, PJ. Vulnerable brains: Research ethics and neurosurgical patients. Journal of Law, Medicine & Ethics 2009;37(1):73–82.Google Scholar

15. See note 2, Goodman, Alterman 2012.

16. Lipsman, NP, Giacobbe, NP, Bernstein, M, Lozano, AM. Informed consent for clinical trials of deep brain stimulation in psychiatric disease: Challenges and implications for trial design. Journal of Medical Ethics 2012;38(2):107–11.Google Scholar

17. Bell, EB, Maxwell, B, McAndrews, MP, Sadikot, A, Racine, E. Hope and patients’ expectations in deep brain stimulation: Healthcare providers’ perspectives and approaches. Journal of Clinical Ethics 2010;21(2):112–24.Google Scholar

18. See note 6, Glannon 2010.

19. See note 5, Dunn et al. 2011.

20. See note 16, Lipsman et al. 2012.

21. Fisher, CE, Dunn, LB, Christopher, PP, Holtzheimer, PE, Leykin, Y, Mayberg, HS, et al. The ethics of research on deep brain stimulation for depression: Decisional capacity and therapeutic misconception. Annals of the New York Academy of Sciences 2012;1265:69–79.Google Scholar

22. See note 10, Nickel 2006.

23. Dubois, JM, Beskow, L, Campbell, J, Dugosh, K, Festinger, D, Hartz, S, et al. Restoring balance: A consensus statement on the protection of vulnerable research participants. American Journal of Public Health 2012;102:2220–5.CrossRefGoogle ScholarPubMed

24. Miller, FG, Fins, JJ. Protecting vulnerable research subjects without unduly constraining neuropsychiatric research. Archives of General Psychiatry 1999;56(8):701–2.Google Scholar

25. See note 5, Dunn et al. 2011.

26. See note 21, Fisher et al. 2012.

27. Pentz, RD, White, M, Harvey, RD, Farmer, ZL, Liu, Y, Lewis, C, et al. Therapeutic misconception, misestimation, and optimism in participants enrolled in phase 1 trials. Cancer 2012;118(18):4571–8.Google Scholar

28. See note 24, Miller, Fins 1999.

29. http://www.ircm.qc.ca/larecherche/axes/neuro/neuroethique/Documents/10.2013.%20Spllementary%20Figure.pdf.