Epidemiology and Infection

Original Papers


Characterization of hepatitis C infection in tuberculosis patients in an urban city in the USA

M. CAMPOa1 c1, A. SHRESTHAa2, E. ORENa2a3, H. THIEDEa2a3, J. DUCHINa2a3, M. NARITAa1a2a3 and K. CROTHERSa1

a1 Department of Pulmonary and Critical Care Medicine, University of Washington, WA, USA

a2 Department of Epidemiology, University of Washington, WA, USA

a3 Public Health – Seattle & King County, WA, USA


The impact of hepatitis C virus infection (HCI), the most common bloodborne virus infection in the USA, on outcome of active tuberculosis (TB) treatment is largely unknown. We aimed to describe characteristics of TB patients with hepatitis C virus infection (TB-HCI) in King County, Washington, including TB treatment duration and outcome. We reviewed 1510 records of patients treated for active TB at the Public Health – Seattle & King County Tuberculosis Control Program between 2000 and 2010, and identified 53 with HCI. Advanced age, being born in the USA, HIV infection, homelessness and injection drug use were independently associated with HCI in TB cases. Independent factors associated with increased treatment duration included HIV infection, excess alcohol use, extrapulmonary TB, and any drug-resistant TB disease. Our findings suggest that TB-HCI patients can be successfully treated for active TB without extending treatment duration.

(Received March 20 2013)

(Revised August 13 2013)

(Accepted August 28 2013)

(Online publication September 25 2013)

Key words

  • Hepatitis C;
  • tuberculosis (TB)


c1 Author for correspondence: Dr M. Campo, Division of Pulmonary and Critical Care Medicine, University of Washington, 325 Ninth Avenue Box 13965, Seattle, WA, USA. (Email: mcampo@u.washington.edu).