Epidemiology and Infection

  • Epidemiology and Infection / Volume 142 / Issue 07 / July 2014, pp 1362-1374
  • Copyright © AbbVie France 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-No Derivatives licence <http://creativecommons.org/licenses/by-nc-nd/3.0/>. The written permission of Cambridge University Press must be obtained for commercial re-use.
  • DOI: http://dx.doi.org/10.1017/S0950268813001738 (About DOI), Published online: 13 September 2013
  • OPEN ACCESS

Original Papers

Respiratory infections

Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

B. FAUROUXa1 c1, J.-B. GOUYONa2, J.-C. ROZEa3, C. GUILLERMET-FROMENTINa4, I. GLORIEUXa5, L. ADAMONa6, M. DI MAIOa7, D. ANGHELESCUa8, T. MILORADOVICHa8, B. ESCANDEa9, C. ELLEAUa10 and D. PINQUIERa11

a1 Armand Trousseau Hospital, Paediatric Pulmonary Department, Research Unit INSERM U 955, National Reference Centre for Rare Lung Diseases, Pierre et Marie Curie University Paris 6, France

a2 Reunion University Hospital – Hospital Group South; Centre of Perinatal Studies of Indian Ocean, Reunion Island, France

a3 Department of Neonatology, Nantes University Hospital, France

a4 Department of Paediatric Intensive Care, Besançon University Hospital, France

a5 Department of Neonatology, Toulouse University Hospital, France

a6 Department of Neonatology, Caen University Hospital, France

a7 Department of Paediatrics and Neonatology, Nîmes University Hospital, France

a8 AbbVie France

a9 Department of Neonatal Intensive Care, Strasbourg University Hospital, France

a10 Department of Paediatrics, Bordeaux University Hospital, France

a11 Department of Neonatology, Rouen University Hospital, France

SUMMARY

The aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39–41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71–13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.

(Received December 21 2012)

(Revised April 24 2013)

(Accepted July 03 2013)

(Online publication September 13 2013)

Key words

  • Asthma;
  • bronchiolitis;
  • hospitalization;
  • morbidity;
  • premature infant;
  • respiratory syncytial virus (RSV);
  • risk factor;
  • wheezing

Correspondence

c1 Author for correspondence: Professor B. Fauroux, Paediatric Pulmonary Department and INSERM U 955, National Reference Centre for Rare Lung Diseases, Pierre et Marie Curie-Paris 6 University, AP-HP, Armand Trousseau Hospital, 26 avenue du Docteur Arnold Netter, 75012 Paris, France. (Email: brigitte.fauroux@trs.aphp.fr).

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