British Journal of Nutrition

Full Papers

Dietary Surveys and Nutritional Epidemiology

Age-dependent effects of cord blood long-chain PUFA composition on BMI during the first 10 years of life

Marie Standla1 c1, Elisabeth Thieringa1a2, Hans Demmelmaira2, Berthold Koletzkoa2 and Joachim Heinricha1

a1 Institute of Epidemiology I, Helmholtz Zentrum München – German Research Centre for Environmental Health, Ingolstädter Landstraße 1, Neuherberg 85764, Germany

a2 University of Munich Medical Centre, Dr von Hauner Children's Hospital, Munich, Germany

Abstract

In the present study, we investigated whether n-6 and n-3 long-chain PUFA (LC-PUFA) concentrations in cord blood (CB) serum are associated with BMI up to 10 years of age, after accounting for LC-PUFA composition at 2, 6 and 10 years. The study was based on 388 participants of the German LISAplus (Influence of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood Plus the Influence of Traffic Emissions and Genetics) birth cohort study carried out in Munich. BMI was measured at 2, 6 and 10 years of age. Serum phospholipid fatty acid concentrations were measured by GC in CB and in blood collected at 2, 6 and 10 years of age. The association between n-3 LC-PUFA and n-6 LC-PUFA concentrations and n-6:n-3 LC-PUFA ratio in CB serum glycerophospholipids and BMI z-scores was assessed using linear mixed models adjusted for LC-PUFA composition at follow-up and potential confounders. Interaction terms between time of follow-up and LC-PUFA concentrations in CB were included. There was no consistent association between n-6 and n-3 LC-PUFA concentrations in CB and BMI over time. However, there was a significant interaction between n-6:n-3 LC-PUFA ratio in CB and time of follow-up with respect to BMI (P= 0·0415): a negative effect at 2 years; no effect at 6 years; a positive effect at 10 years. BMI up to 10 years of age may be influenced by the n-6:n-3 ratio in CB serum glycerophospholipids in a time-varying fashion. The present results thereby highlight the importance of considering age when examining associations between fatty acid concentrations and BMI.

(Received August 12 2013)

(Revised December 19 2013)

(Accepted January 10 2014)

(Online publication February 13 2014)

Key Words:

  • BMI;
  • Children;
  • PUFA;
  • Epidemiology;
  • Cord blood

Correspondence

c1 Corresponding author: M. Standl, fax +49 89 31873380, email marie.standl@helmholtz-muenchen.de

Footnotes

  Abbreviations: AA, arachidonic acid; CB, cord blood; LC-PUFA, long-chain PUFA; zBMI, BMI z-scores

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