British Journal of Nutrition

Research Article

Conjugated linoleic acid increased C-reactive protein in human subjects

Annika Smedmana1 c1, Samar Basua1, Stefan Jovingea2, Gunilla Nordin Fredriksona2 and Bengt Vessbya1

a1 Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

a2 Department of Medicine/Cardiology, University Hospital MAS, Lund University, Malmö, Sweden


We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4·2g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0·003) compared with the control group. However, no changes in TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

(Received June 09 2004)

(Revised August 19 2004)

(Accepted December 20 2004)


c1 *Corresponding author: Dr Annika Smedman, fax +46 18 611 79 76, email