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Influence of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in coronary heart disease patients: a systematic review

Published online by Cambridge University Press:  08 March 2007

Mark Hamer  and
Andrew Steptoe
Mark Hamer*
Affiliation:
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WCIE 6BT, UK
Andrew Steptoe
Affiliation:
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WCIE 6BT, UK
*
*Corresponding author: Dr Mark Hamer, fax +44 20 7916 8542, emailm.hamer@ucl.ac.uk
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Abstract

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Epidemiological evidence suggests that the diet influences CHD risk, although the protective effects of dietary intervention for patients in diseased states has gained less attention. Secondary care prevention strategies for patients often involves drug therapy that is expensive and can result in undesirable side effects. Therefore, it is potentially beneficial to utilise other strategies, such as diet, in the management of CHD. A systematic review was conducted to examine the effects of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in CHD patients. Results show substantial evidence for the efficacy of n–3 oils in reducing cardiovascular mortality and one mechanism may be related to the stabilisation of vulnerable atherosclerotic plaques, although the effects on progression of atherosclerosis, haemostatic activity and vascular inflammation remain equivocal. Promising data also exist for the efficacy of flavonoid-rich foods for improving endothelial function, although strong clinical endpoint evidence is lacking. The variation in the efficacy of certain nutrients in CHD patients may be explained by genetics, existing risk factors, psychosocial factors and methodological issues, although these are often not adequately taken into consideration. We conclude that there is a need to undertake more appropriately designed trials in specific clinical populations, controlling for additional lifestyle and risk factors, examining potential interactions with medications, and also establishing methods to increase compliance to dietary recommendations before specific nutrients can be widely prescribed for secondary prevention. Future research should also utilise techniques that provide a direct measure of atherosclerosis.

Keywords

Coronary heart disease managementFish oilsoilsFlavonoidsEndothelial functionInflammation
Type
Review Article
Information
British Journal of Nutrition , Volume 95 , Issue 5 , May 2006 , pp. 849 - 859
Copyright
Copyright © The Nutrition Society 2006

References

Agewall, S, Wright, S, Doughty, RN, Whalley, GA, Duxbury, M & Sharpe, NDoes a glass of red wine improve endothelial function?. Eur Heart J 2000 21 74–78.CrossRefGoogle Scholar
Aguilar, D, Skali, H, Moye, LAet al. Alcohol consumption and prognosis in patients with left ventricular systolic dysfunction after a myocardial infarction. J Am Coll Cardiol 2004 43 2015–2021.CrossRefGoogle ScholarPubMed
Angerer, P, Kothny, W, Stork, S & von Schacky, CEffect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries. Cardiovasc Res 2002 54 183–190.CrossRefGoogle ScholarPubMed
Anter, E, Thomas, SR, Schulz, E, Shapira, OM, Vita, JA & Keaney, JFJr Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem 2004 279 46637–46643.CrossRefGoogle ScholarPubMed
Barth, J, Schumacher, M & Herrmann-Lingen, CDepression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med 2004 66 802–813.CrossRefGoogle ScholarPubMed
Barzi, F, Woodward, M, Marfisi, RM, Tavazzi, L, Valagussa, F & Marchioli RGISSI-Prevenzione Investigators Mediterranean diet and all-causes mortality after myocardial infarction: results from the GISSI-Prevenzione trial. Eur J Clin Nutr 2003 57 604–611.CrossRefGoogle ScholarPubMed
Baumann, KH, Hessel, F, Larass, I, Muller, T, Angerer, P, Kiefl, R & von Schacky, CDietary omega-3, omega-6, and omega-9 unsaturated fatty acids and growth factor and cytokine gene expression in unstimulated and stimulated monocytes. A randomized volunteer study. Arterioscler Thromb Vasc Biol 1999 19 59–66.CrossRefGoogle ScholarPubMed
Berstad, P, Seljeflot, I, Veierod, MB, Hjerkinn, EM, Arnesen, H & Pedersen, JISupplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. Clin Sci (Lond) 2003 105 13–20.CrossRefGoogle ScholarPubMed
Blake, GJ & Ridker, PMNovel clinical markers of vascular wall inflammation. Circ Res 2001 89 763–771.CrossRefGoogle ScholarPubMed
Bobak, M & Marmot, MAlcohol and coronary heart diease. In Coronary Heart Disease Epidemiology – from Etiology to Public Health, 2nd ed., Marmot, M & Elliott, POxfordOxford University Press 2005 251–263.Google Scholar
Bucher, HC, Hengstler, P, Schindler, C & Meier, Gn-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002 112 298–304.CrossRefGoogle ScholarPubMed
Burr, ML, Ashfield-Watt, PA, Dunstan, FD, Fehily, AM, Breay, P, Ashton, T, Zotos, PC, Haboubi, NA & Elwood, PCLack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 2003 57 193–200.CrossRefGoogle ScholarPubMed
Burr, ML, Fehily, AM, Gilbert, JF, Rogers, S, Holliday, RM, Sweetnam, PM, Elwood, PC & Deadman, NMEffects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction:diet and reinfarction trial (DART). Lancet 1989 ii 757–761.CrossRefGoogle Scholar
Chou, EJ, Keevil, JG, Aeschlimann, S, Wiebe, DA, Folts, JD & Stein, JHEffect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 2001 88 553–555.CrossRefGoogle ScholarPubMed
Clouse, ME, Chen, J, Krumholz, HM, Clouse, ME, Chen, J & Krumholz, HMNoninvasive screening for coronary artery disease with computed tomography is useful. Circulation 2006 113 125–146.CrossRefGoogle ScholarPubMed
Collins, TEndothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab Invest 1993 68 499–508.Google ScholarPubMed
Cooper, HA, Exner, DV & Domanski, MJLight-to-moderate alcohol consumption and prognosis in patients with left ventricular systolic dysfunction. J Am Coll Cardiol 2000 35 1753–1759.CrossRefGoogle ScholarPubMed
Danesh, J, Wheeler, JG, Hirschfield, GM, Eda, S, Eiriksdottir, G, Rumley, A, Lowe, GD, Pepys, MB & Gudnason, VC-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004 350 1387–1397.CrossRefGoogle Scholar
Davies, JR, Rudd, JH & Weissberg, PLMolecular and metabolic images of atherosclerosis. J Nucl Med 2004 45 1898–1907.Google ScholarPubMed
de Lorgeril, M & Salen, PDietary prevention of post-angioplasty restenosis. From illusion and disillusion to pragmatism. Nutr Metab Cardiovasc Dis 2003 13 345–348.CrossRefGoogle ScholarPubMed
de Lorgeril, M, Salen, P, Martin, JL, Boucher, F, Paillard, F & de Leiris, JWine drinking and risks of cardiovascular complications after recent acute myocardial infarction. Circulation 2002 106 1465–1469.CrossRefGoogle ScholarPubMed
de Lorgeril, M, Salen, P, Martin, JL, Monjaud, I, Delaye, J & Mamelle, NMediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999 99 779–785.CrossRefGoogle ScholarPubMed
Djousse, L, Arnett, DK, Carr, JJ, Eckfeldt, JH, Hopkins, PN, Province, MA & Ellison, RCInvestigators of the NHLBI FHS Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 2005 111 2921–2926.CrossRefGoogle ScholarPubMed
Doshi, S, McDowell, I, Moat, S, Lewis, M & Goodfellow, JFolate improves endothelial function in patients with coronary heart disease. Clin Chem Lab Med 2003 41 1505–1512.CrossRefGoogle ScholarPubMed
Duffy, SJ, Keaney, JF Jr, Holbrook, M, Gokce, N, Swerdloff, PL, Frei, B & Vita, JAShort- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001a 104 151–156.CrossRefGoogle Scholar
Duffy, SJ, Vita, JA, Holbrook, M, Swerdloff, PL & Jr Keaney, JFEffect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2001b 21 1084–1089.CrossRefGoogle ScholarPubMed
Eritsland, J, Seljeflot, I, Arnesen, H, Westvik, AB & Kierulf, PEffect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. Thromb Res 1995 77 337–346.CrossRefGoogle ScholarPubMed
Erkkila, AT, Lichtenstein, AH, Mozaffarian, D & Herrington, DMFish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Am J Clin Nutr 2004 80 626–632.CrossRefGoogle ScholarPubMed
Franco, OH, Bonneux, L, de Laet, C, Peeters, A, Steyerber, EW & Mackenbach, JPThe Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%. BMJ 2004 329 1447–1450.CrossRefGoogle Scholar
Frasure-Smith, N, Lesperance, F & Julien, PMajor depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol Psychiatry 2004 55 891–896.CrossRefGoogle ScholarPubMed
Frijns, CJ, Kappelle, LJ, van Gijn, J, Nieuwenhuis, HK, Sixma, JJ & Fijnheer, RSoluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis. Stroke 1997 28 2214–2218.CrossRefGoogle ScholarPubMed
GISSI-Prevenzione Investigators Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999 354 447–455.CrossRefGoogle Scholar
Grimble, RF, Howell, WM, O'Reilly, G, Turner, SJ, Markovi, O, Hirrell, S, East, JM & Calder, PCThe ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 2002 76 454–459.CrossRefGoogle ScholarPubMed
Grundt, H, Nilsen, DW, Mansoor, MA, Hetland, O & Nordoy, AReduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb 2003 33 88–95.CrossRefGoogle Scholar
Hamer, M, Owen, G & Kloek, JThe role of functional foods in the psychobiology of health and disease. Nutr Res Rev 2005 18 1–13.CrossRefGoogle ScholarPubMed
Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20, 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002 360 23–33.CrossRefGoogle Scholar
Heiss, C, Dejam, A, Kleinbongard, P, Schewe, T, Sies, H & Kelm, MVascular effects of cocoa rich in flavan-3-ols. JAMA 2003 290 1030–1031.CrossRefGoogle Scholar
Hill, ABThe environment and disease: association or causation? Proc Royal Soc Med 1965 58 295–300.CrossRefGoogle ScholarPubMed
Hodgson, M, Burke, V & Puddey, IBAcute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens 2005 23 47–54.CrossRefGoogle ScholarPubMed
Hong, MK, Mintz, GS, Popma, JJ, Kent, KM, Pichard, AD, Satler, LF & Leon, MBLimitations of angiography coronary atherosclerosis progression or regression. Ann Intern Med 1994 121 348–354.CrossRefGoogle ScholarPubMed
Hornig, BVitamins, antioxidants and endothelial function in coronary artery disease. Cardiovasc Drugs Ther 2002 16 401–409.CrossRefGoogle ScholarPubMed
Johansen, O, Seljeflot, I, Hostmark, AT & Arnesen, HThe effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coronary heart disease. Arterioscler Thromb Vasc Biol 1999 19 1681–1686.CrossRefGoogle ScholarPubMed
Joshipura, KJ, Hu, FB, Manson, JEet al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 2001 134 1106–1114.CrossRefGoogle ScholarPubMed
Kalin, R, Righi, A, Del Rosso, A, Bagchi, D, Generini, S, Cerinic, MM & Das, DKActivin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res 2002 36 819–825.CrossRefGoogle ScholarPubMed
Karatzi, K, Papamichael, C, Aznaouridis, K, Aznaouridis, K, Papaioannou, T, Protogerou, A, Stamatelopoulos, K, Zampelas, A, Lekakis, J & Mavrikakis, MConstituents of red wine other than alcohol improve endothelial function in patients with coronary artery disease. Coron Artery Dis 2004 15 485–490.CrossRefGoogle ScholarPubMed
Karatzi, K, Papamichael, C, Karatzis, EN, Papaioannou, TG, Aznaouridis, KA, Katsichti, PP, Stamatelopoulos, KS, Zampelas, A, Lekakis, JP & Mavrikakis, MERed wine induces favourable effects on wave reflections and central pressures in coronary artery disease patients. Am J Hypertens 2005 18 1161–1167.CrossRefGoogle ScholarPubMed
Khera, A, de Lemos, JA, Peshock, RM, Lo, HS, Stanek, HG, Murphy, SA, Wians, FH Jr, Grundy, SM & McGuire, DKRelationship between C-reactive protein and subclinical atherosclerosis: the Dallas Heart Study. Circulation 2006 113 38–43.CrossRefGoogle ScholarPubMed
Kothny, W, Angerer, P, Stork, S & von Schacky, CShort term effects of omega-3 fatty acids on the radial artery of patients with coronary artery disease. Atherosclerosis 1998 140 181–186.CrossRefGoogle ScholarPubMed
Kris-Etherton, PM, Harris, WS & Appel, LJFish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002 106 2747–2757.CrossRefGoogle ScholarPubMed
Leeson, CP, Hingorani, AD, Mullen, MJ, Jeerooburkhan, N, Kattenhorn, M, Cole, TJ, Muller, DP, Lucas, A, Humphries, SE & Deanfield, JEGlu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002 90 1153–1158.CrossRefGoogle ScholarPubMed
Lembo, G, Vecchione, C, Izzo, R, Fratta, L, Fontana, D, Marino, G, Pilato, G & Trimarco, BNoradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity. Circulation 2000 102 552–557.CrossRefGoogle ScholarPubMed
Levine, GN, Frei, B, Koulouris, SN, Gerhard, MD, Keaney, JF Jr & Vita, JAAscorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996 93 1107–1113.CrossRefGoogle ScholarPubMed
Libby, PInflammation in atherosclerosis. Nature 2002 420 868–874.CrossRefGoogle ScholarPubMed
Liem, A, Reynierse-Buitenwerf, GH, Zwinderman, AH, Jukema, JW & van Veldhuisen, DJSecondary prevention with folic acid: effects on clinical outcomes. J Am Coll Cardiol 2003 41 2105–2113.CrossRefGoogle ScholarPubMed
Liu, S, Lee, IM, Ajani, U, Cole, SR, Buring, JE & Manson, JEIntake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study. Int J Epidemiol 2001 30 130–135.CrossRefGoogle Scholar
Lonn, E, Bosch, J & Yusuf, FHOPE et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer. JAMA 2005 293 1338–1347.Google ScholarPubMed
Lorenz, M, Wessler, S, Follmann, E, Michaelis, W, Dusterhoft, T, Baumann, G, Stangl, K & Stangl, VA constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 2004 279 6190–6195.CrossRefGoogle ScholarPubMed
Michelson, AD, Barnard, MR, Krueger, LA, Valeri, CR & Furman, MICirculating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface Pselectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 2001 104 1533–1537.CrossRefGoogle ScholarPubMed
Miller, GJDietary fatty acids and the haemostatic system. Atherosclerosis 2005 179 213–227.CrossRefGoogle ScholarPubMed
Moat, SJ, Doshi, SN, Lang, D, McDowell, IF, Lewis, MJ & Goodfellow, JTreatment of coronary heart disease with folic acid: is there a future? Am J Physiol 2004 287H 1–7.Google Scholar
Mukamal, KJ, Maclure, M, Muller, JE & Mittleman, MABinge drinking and mortality after acute myocardial infarction. Circulation 2005 112 3839–3845.CrossRefGoogle ScholarPubMed
Mukamal, KJ, Maclure, M, Muller, JE, Sherwood, JB & Mittleman, MAPrior alcohol consumption and mortality following acute myocardial infarction. JAMA 2001 285 1965–1970.CrossRefGoogle ScholarPubMed
Mukamal, KJ, Maclure, M, Muller, JE, Sherwood, JB & Mittleman, MA 2002 Tea consumption and mortality after acute myocardial infarction. Circulation. 105 2476–2481.CrossRefGoogle ScholarPubMed
Muntwyler, J, Hennekens, CH, Buring, JE & Gaziano, JM (1998) Mortality and light to moderate alcohol consumption after myocardial infarction. Lancet 352 1882–1885.CrossRefGoogle ScholarPubMed
Nielsen, NR, Schnohr, P, Jensen, G & Gronbaek, MIs the relationship between type of alcohol and mortality influenced by socio-economic status? J Intern Med (2004) 255 280–288.CrossRefGoogle ScholarPubMed
Nygard, O, Nordrehaug, JE, Refsum, H, Ueland, PM, Farstad, M & Vollset, SEPlasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med (1997) 337 230–236.CrossRefGoogle ScholarPubMed
Preli, RB, Klein, KP & Herrington, DMVascular effects of dietary L-arginine supplementation. Atherosclerosis 2002 162 1–15.CrossRefGoogle ScholarPubMed
Rapola, JM, Virtamo, J, Ripatti, S, Huttunen, JK, Albanes, D, Taylor, PR & Heinonen, OPRandomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 1997 349 1715–1720.CrossRefGoogle ScholarPubMed
Renaud, S, deLorgeril, M, Delaye, J, Guidollet, J, Jacquard, F, Mamelle, N, Martin, JL, Monjaud, I, Salen, P & Toubol, PCretan Mediterranean diet for prevention of coronary heart disease. Am J Clin Nutr (1995) 61 Suppl. 6 1360S–1367S.CrossRefGoogle ScholarPubMed
Robertson, RM & Smaha, LCan a Mediterranean-style diet reduce heart disease?. Circulation (2001) 103 1821–1822.CrossRefGoogle ScholarPubMed
Ross, RMechanisms of disease: atherosclerosis an inflammatory disease. New Eng J Med (1999) 340 115–126.CrossRefGoogle Scholar
Rozanski, A, Blumenthal, JA, Davidson, KW, Saab, PG & Kubzansky, LThe epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol (2005) 45 637–651.CrossRefGoogle ScholarPubMed
Sacks, FM, Stone, PH, Gibson, CMSilverman, DI, Rosner, B & Pasternak, RCControlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group. J Am Coll Cardiol (1995) 25 1492–1498.CrossRefGoogle ScholarPubMed
Seierstad, SL, Seljeflot, I, Johansen, O, Hansen, R, Haugen, M, Rosenlund, G, Frøyland, L & Arnesen, HDietary intake of differently fed salmon; the influence on markers of human atherosclerosis. Eur J Clin Invest (2005) 35 52–59.CrossRefGoogle ScholarPubMed
Seljeflot, I, Johansen, O, Arnesen, H, Eggesbo, JBWestvik, AB & Kierulf, PProcoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis supplemented with omega-3 fatty acids. Thromb Haemost (1999) 81 566–570.Google ScholarPubMed
Shaper, AG & Wannamethee, SGAlcohol intake and mortality in middle aged men with diagnosed coronary heart disease. Heart (2000) 83 394–399.CrossRefGoogle ScholarPubMed
Solzbach, U, Hornig, B, Jeserich, M & Just, HVitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation (1997) 96 1513–1519.CrossRefGoogle ScholarPubMed
Stein, JH, Keevil, JG, Wiebe, DA, Aeschlimann, S & Folts, JDPurple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation (1999) 100 1050–1055.CrossRefGoogle ScholarPubMed
Steinberg, DClinical trials of antioxidants in atherosclerosis: are we doing the right thing? Lancet (1995) 346 36–38.CrossRefGoogle ScholarPubMed
Stephens, NG, Parsons, A, Schofield, PM, Kelly, F, Cheeseman, K & Mitchinson, MJRandomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet (1996) 347 781–786.CrossRefGoogle ScholarPubMed
Strike, PC, Magid, K, Brydon, L, Edwards, S, McEwan, JR & Steptoe, AExaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery disease. Psychosom Med (2004) 66 492–500.CrossRefGoogle ScholarPubMed
Strike, PC & Steptoe, ASystematic review of mental stress-induced myocardial ischaemia. Eur Heart J (2003) 24 690–703.CrossRefGoogle ScholarPubMed
Strike, PC, Steptoe, ABehavioral and emotional triggers of acute coronary syndromes: a systematic review and critique. Psychosom Med (2005) 67 179–186.CrossRefGoogle ScholarPubMed
Taddei, S, Virdis, A, Ghiadoni, L, Magagna, A & Salvetti, AVitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation (1998) 97 2222–2229.CrossRefGoogle ScholarPubMed
Thies, F, Garry, JM, Yaqoob, P, Rerkasem, K, Williams, J, Shearman, CP, Gallagher, PJ, Calder, PC & Grimble, RFAssociation of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. uLancet (2003) 361 477–485.CrossRefGoogle ScholarPubMed
Thun, MJ, Peto, R, Lopez, AD, Monaco, JH, Henley, SJ, Heath, CW Jr & Doll, RAlcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med (1997) 337 1705–1714.CrossRefGoogle ScholarPubMed
Toole, JF, Malinow, MR, Chambless, LESpence, JD, Pettigrew, LC, Howard, VJ, Sides, EG, Wang, CH & Stampfer, MLowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA (2004) 291 565–575.CrossRefGoogle ScholarPubMed
Vita, JATea consumption and cardiovascular disease: effects on endothelial function. J Nutr (2003) 133 3293S–3297S.CrossRefGoogle ScholarPubMed
Vita, JAThe effects of flavonoids on the vascular endothelium Am J Clin Nutr (2005) 81 292S–297S.CrossRefGoogle Scholar
Vita, JA & Keaney, JF JrEndothelial function: a barometer for cardiovascular risk? Circulation (2002) 106 640–642.CrossRefGoogle ScholarPubMed
von Schacky, C, Angerer, P, Kothny, W, Theisen, K & Mudra, HThe effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (1999) 130 554–562.CrossRefGoogle ScholarPubMed
Waters, DD, Alderman, EL & Hsia, JEffects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA (2002) 288 2432–2440.CrossRefGoogle ScholarPubMed
Whelan, AP, Sutherland, WH, McCormick, MP, Yeoman, DJ, de Jong, SA & Williams, MJEffects of white and red wine on endothelial function in subjects with coronary artery disease. Intern Med J (2004) 34 224–228.CrossRefGoogle ScholarPubMed
Whelton, SP, He, J, Whelton, PK & Muntner, PMeta-analysis of observational studies on fish intake and coronary heart disease. Am J Cardiol (2004) 93 1119–1123.CrossRefGoogle ScholarPubMed
White, CSuspected research fraud: difficulties of getting at the truth. BMJ (2005) 331 281–288.CrossRefGoogle ScholarPubMed
Widlansky, ME, Duffy, SJ, Hamburg, NM, Gokce, N, Warden, BA, Wiseman, S, Keaney, JF JrFrei, B & Vita, JAEffects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med (2005) 38 499–506.CrossRefGoogle ScholarPubMed
Williams, MJ, Sutherland, WH, Whelan, AP, McCormick, MP & de Jong, SAAcute effect of drinking red and white wines on circulating levels of inflammation-sensitive molecules in men with coronary artery disease. Metabolism (2004) 53 318–323.CrossRefGoogle ScholarPubMed
Zeitler, H, Ko, Y, Zimmermann, C, Nickenig, G, Glanzer, K, Walger, P, Sachinidis, A & Vetter, HElevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction. Eur J Med Res (1997) 2 389–394.Google ScholarPubMed