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Cold-pressed flaxseed oil reverses age-associated depression in a primary cell-mediated adaptive immune response in the mouse

Published online by Cambridge University Press:  08 March 2007

L. M. Hillyer ,
A. M. Sandiford ,
C. E. Gray  and
Bill Woodward
L. M. Hillyer
Affiliation:
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
A. M. Sandiford
Affiliation:
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
C. E. Gray
Affiliation:
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Bill Woodward*
Affiliation:
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
*
*Corresponding author: fax +1 519 763 5902 email wwoodwar@uoguelph.ca
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Abstract

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The objective of this investigation was to determine the influence of flaxseed oil on responses representative of primary humoral and cell-mediated adaptive immune competence in immunosenescent mice. Male and female C57BL/6J mice, 85 weeks old, were randomized between two complete purified diets differing only in oil source (cold-pressed safflower or flaxseed). After 8 weeks, humoral competence was assessed in six mice per group as the serum haemagglutinin titre to sheep red blood cells (SRBC) and cell-mediated competence was assessed, in an additional six mice per group, as the delayed hypersensitivity response to SRBC. A zero-time control group (88 weeks old) and a young adult positive control group (12 weeks old) were each tested similarly (six per immune response), revealing age-related depression in both antibody and cell-mediated competence at 88 weeks of age. After the 8-week experimental period, the antibody response of the two test groups of geriatric mice remained below the young adult level (P=0·04) and the cell-mediated response of the saffloweroil group also continued to exhibit age-related depression (20% of young adult level, P=0·0002). By contrast, the anti-SRBC delayedhypersensitivity response of the flaxseed group no longer differed from the response of the young adults but exceeded that of the safflower and zero-time control senescent groups (P=0·0002). Depression in primary cell-mediated competence, the most outstanding aspect of immunosenescence, can be addressed by means of a dietary source of 18:3n-3 without longer-chain PUFA.

Keywords

AgeingCell-mediated immunityFlaxseed oilMouse
Type
Short communication
Information
British Journal of Nutrition , Volume 95 , Issue 2 , February 2006 , pp. 230 - 233
Copyright
Copyright © The Nutrition Society 2006

References

Bechoua, SDubois, MVericel, EChapuy, PLagarde, M&Prigent, A-FInfluence of very low dietary intake of marine oil on some functional aspects of immune cells in healthy elderly people. Br J Nutr 2003 89 523–531CrossRefGoogle ScholarPubMed
Beharka, AAWu, DHan, SN&Meydani, SNMacrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech Ageing Dev 1997 93 59&77CrossRefGoogle Scholar
Betz, M&Fox, BSProstaglandin E2 inhibits production of Th1 lymphokines but not of Th2 J Immunol 1991 146 108&113CrossRefGoogle Scholar
Bogden, JD&Louria, DBNutrition and immunity in the elderlyIn Diet and Human Immune Function [DA Hughes, LG Darlington and A Bendich, editors]Totowa, NJHumana Press 2004CrossRefGoogle Scholar
Caughey, GEMantzioris, EGibson, RACleland, LG&James, MJThe effect on human tumor necrosis factor a and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 1996 63 116&122CrossRefGoogle ScholarPubMed
Fan, Y-YMcMurray, DNLy, LH&Chapkin, RSDietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts. J Nutr 2003 133 1913&1920CrossRefGoogle ScholarPubMed
Ginaldi, LLoreto, MFCorsi, MPModesti, M&de Martinis, MImmunosenescence and infectious diseases. Microbes Infect 2001 3 851&857CrossRefGoogle ScholarPubMed
Ha, CLWong, SLGray, MMWatt, JHillyer, Hillyer&Woodward, BDOverabundance of CD45RA+ (Quiescent-Phenotype) cells within the involuted CD4+T-cell population follows initiation of immune depression in energy-deficient weanling mice and reflects involution exclusive to the CD45RA subset. J Nutr 2001 131 1812&1818Google Scholar
Hillyer, LM&Woodward, BA comparison of the capacity of six cold-pressed plant oils to support development of acquired immune competence in the weanling mouse: superiority of lowlinoleic-acid oils. Br J Nutr 2002 88 171&181CrossRefGoogle ScholarPubMed
Holub, DJ&Holub, BJOmega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 2004 263 217 &225CrossRefGoogle ScholarPubMed
Meydani, SNEndres, SWoods, MMGoldin, BRSoo, CMorrill-Labrode, ADinarello, CA&Gorbach, SLOral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J Nutr 1991 121 547–555CrossRefGoogle Scholar
Wander, RCHall, JAGradin, JLDu, S-H&Jewell, DEThe ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. J Nutr 1997 127 1198–1205CrossRefGoogle Scholar