Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-19T02:01:58.883Z Has data issue: false hasContentIssue false
  • English
  • Français

Default network connectivity as a vulnerability marker for obsessive compulsive disorder

Published online by Cambridge University Press:  04 September 2013

Z. W. Peng ,
T. Xu ,
Q. H. He ,
C. Z. Shi ,
Z. Wei ,
G. D. Miao ,
J. Jing ,
K. O. Lim ,
X. N. Zuo  and
R. C. K. Chan
Z. W. Peng
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Psychology, South China Normal University, Guangzhou, People's Republic of China Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China
T. Xu
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China Key Laboratory of Behavioral Science, Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China
Q. H. He
Affiliation:
Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China
C. Z. Shi
Affiliation:
Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China
Z. Wei
Affiliation:
Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China
G. D. Miao
Affiliation:
Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China
J. Jing
Affiliation:
Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China
K. O. Lim
Affiliation:
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
X. N. Zuo*
Affiliation:
Key Laboratory of Behavioral Science, Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China
R. C. K. Chan*
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China
*
*Address for correspondence: R. C. K. Chan, Ph.D. and Xi-Nian Zuo, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, People's Republic of China. (Email: rckchan@psych.ac.cn) [R.C.K.C.] (Email: zuoxn@psych.ac.cn) [X.N.Z.]
*Address for correspondence: R. C. K. Chan, Ph.D. and Xi-Nian Zuo, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, People's Republic of China. (Email: rckchan@psych.ac.cn) [R.C.K.C.] (Email: zuoxn@psych.ac.cn) [X.N.Z.]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown.

Method

Here, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population.

Results

Compared with healthy controls, OCD patients exhibited reduced strength of default network functional connectivity with the posterior cingulate cortex (PCC), and increased functional connectivity in the right inferior frontal lobe, insula, superior parietal cortex and superior temporal cortex, while their unaffected first-degree siblings only showed reduced local connectivity in the PCC.

Conclusions

These findings suggest that the disruptions of default network functional connectivity might be associated with family history of OCD. The decreased default network connectivity in both OCD patients and their unaffected siblings may serve as a potential marker of OCD.

Keywords

Default networkfunctional connectivitygenetic riskobsessive compulsive disorderresting-state fMRI
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 7 , May 2014 , pp. 1475 - 1484
Copyright
Copyright © Cambridge University Press 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andrews-Hanna, JR, Reidler, JS, Sepulcre, J, Poulin, R, Buckner, RL (2010). Functional–anatomic fractionation of the brain's default network. Neuron 65, 550–562.Google Scholar
Beck, AT, Steer, RA (1984). Internal consistencies of the original and revised Beck Depression Inventory. Journal of Clinical Psychology 40, 1365–1367.Google Scholar
Bernal-Rusiel, JL, Greve, DN, Reuter, M, Fischl, B, Sabuncu, MR (2012). Statistical analysis of longitudinal neuroimage data with Linear Mixed Effects models. Neuroimage 66C, 249–260.Google Scholar
Biswal, BB, Mennes, M, Zuo, XN, Gohel, S, Kelly, C, Smith, SM, Beckmann, CF, Adelstein, JS, Buckner, RL, Colcombe, S, Dogonowski, AM, Ernst, M, Fair, D, Hampson, M, Hoptman, MJ, Hyde, JS, Kiviniemi, VJ, Kotter, R, Li, SJ, Lin, CP, Lowe, MJ, Mackay, C, Madden, DJ, Madsen, KH, Margulies, DS, Mayberg, HS, McMahon, K, Monk, CS, Mostofsky, SH, Nagel, BJ, Pekar, JJ, Peltier, SJ, Petersen, SE, Riedl, V, Rombouts, SA, Rypma, B, Schlaggar, BL, Schmidt, S, Seidler, RD, Siegle, GJ, Sorg, C, Teng, GJ, Veijola, J, Villringer, A, Walter, M, Wang, L, Weng, XC, Whitfield-Gabrieli, S, Williamson, P, Windischberger, C, Zang, YF, Zhang, HY, Castellanos, FX, Milham, MP (2010). Toward discovery science of human brain function. Proceedings of the National Academy of Sciences USA 107, 4734–4739.CrossRefGoogle ScholarPubMed
Broyd, SJ, Demanuele, C, Debener, S, Helps, SK, James, CJ, Sonuga-Barke, EJ (2009). Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience and Biobehavioral Reviews 33, 279–296.Google Scholar
Buckner, RL, Andrews-Hanna, JR, Schacter, DL (2008). The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences 1124, 1–38.CrossRefGoogle ScholarPubMed
Cabeza, R, Dolcos, F, Graham, R, Nyberg, L (2002). Similarities and differences in the neural correlates of episodic memory retrieval and working memory. Neuroimage 16, 317–330.Google Scholar
Cannistraro, PA, Makris, N, Howard, JD, Wedig, MM, Hodge, SM, Wilhelm, S, Kennedy, DN, Rauch, SL (2007). A diffusion tensor imaging study of white matter in obsessive–compulsive disorder. Depression and Anxiety 24, 440–446.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Fineberg, NA, Menzies, LA, Blackwell, AD, Bullmore, ET, Robbins, TW, Sahakian, BJ (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive–compulsive disorder. American Journal of Psychiatry 164, 335–338.Google Scholar
Chamberlain, SR, Menzies, L, Hampshire, A, Suckling, J, Fineberg, NA, del Campo, N, Aitken, M, Craig, K, Owen, AM, Bullmore, ET, Robbins, TW, Sahakian, BJ (2008). Orbitofrontal dysfunction in patients with obsessive–compulsive disorder and their unaffected relatives. Science 321, 421–422.Google Scholar
Chang, C, Glover, GH (2010). Time-frequency dynamics of resting-state brain connectivity measured with fMRI. Neuroimage 50, 81–98.Google Scholar
Chiong, W, Wilson, SM, D'Esposito, M, Kayser, AS, Grossman, SN, Poorzand, P, Seeley, WW, Miller, BL, Rankin, KP (2013). The salience network causally influences default mode network activity during moral reasoning. Brain 136, 1929–1941.CrossRefGoogle ScholarPubMed
Dosenbach, NU, Fair, DA, Miezin, FM, Cohen, AL, Wenger, KK, Dosenbach, RA, Fox, MD, Snyder, AZ, Vincent, JL, Raichle, ME, Schlaggar, BL, Petersen, SE (2007). Distinct brain networks for adaptive and stable task control in humans. Proceedings of the National Academy of Sciences USA 104, 11073–11078.Google Scholar
Dosenbach, NU, Nardos, B, Cohen, AL, Fair, DA, Power, JD, Church, JA, Nelson, SM, Wig, GS, Vogel, AC, Lessov-Schlaggar, CN, Barnes, KA, Dubis, JW, Feczko, E, Coalson, RS, Pruett, JR Jr., Barch, DM, Petersen, SE, Schlaggar, BL (2010). Prediction of individual brain maturity using fMRI. Science 329, 1358–1361.Google Scholar
First, MB, Spitzer, RL, Gibbon, M, Williams, JB (1996). Structured Clinical Interview for DSM-IV Axis I Disorder, Research Version, Patient Edition (SCID-I/P,Version 2.0). Biometrics Research Department, New York State Psychiatric Institute: New York.Google Scholar
First, MB, Spitzer, RL, Gibbon, M, Williams, JB (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-Patient Edition (SCID-I/NP). Biometrics Research Department, New York State Psychiatric Institute: New York.Google Scholar
Fitzgerald, KD, Stern, ER, Angstadt, M, Nicholson-Muth, KC, Maynor, MR, Welsh, RC, Hanna, GL, Taylor, SF (2010). Altered function and connectivity of the medial frontal cortex in pediatric obsessive–compulsive disorder. Biological Psychiatry 68, 1039–1047.Google Scholar
Fitzgerald, KD, Welsh, RC, Stern, ER, Angstadt, M, Hanna, GL, Abelson, JL, Taylor, SF (2011). Developmental alterations of frontal–striatal–thalamic connectivity in obsessive–compulsive disorder. Journal of the American Academy of Child Adolescent Psychiatry 50, 938–948.e3.CrossRefGoogle ScholarPubMed
Foa, EB, Huppert, JD, Leiberg, S, Langner, R, Kichic, R, Hajcak, G, Salkovskis, PM (2002). The Obsessive–Compulsive Inventory: development and validation of a short version. Psychological Assessment 14, 485–496.CrossRefGoogle ScholarPubMed
Fox, MT, Barense, MD, Baxter, MG (2003). Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortex. Journal of Neuroscience 23, 676–681.Google Scholar
Goodman, WK, Price, LH, Rasmussen, SA, Mazure, C, Fleischmann, RL, Hill, CL, Heninger, GR, Charney, DS (1989). The Yale–Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry 46, 1006–1011.Google Scholar
Gusnard, DA, Akbudak, E, Shulman, GL, Raichle, ME (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences USA 98, 4259–4264.Google Scholar
Hagmann, P, Cammoun, L, Gigandet, X, Meuli, R, Honey, CJ, Wedeen, VJ, Sporns, O (2008). Mapping the structural core of human cerebral cortex. PLoS Biology 6, e159.CrossRefGoogle ScholarPubMed
Hanna, GL, Veenstra-VanderWeele, J, Cox, NJ, Boehnke, M, Himle, JA, Curtis, GC, Leventhal, BL, Cook, EH Jr. (2002). Genome-wide linkage analysis of families with obsessive–compulsive disorder ascertained through pediatric probands. American Journal of Medical Genetics 114, 541–552.CrossRefGoogle ScholarPubMed
Harrison, BJ, Soriano-Mas, C, Pujol, J, Ortiz, H, Lopez-Sola, M, Hernandez-Ribas, R, Deus, J, Alonso, P, Yucel, M, Pantelis, C, Menchon, JM, Cardoner, N (2009). Altered corticostriatal functional connectivity in obsessive–compulsive disorder. Archives of General Psychiatry 66, 1189–1200.Google Scholar
Hou, J, Wu, W, Lin, Y, Wang, J, Zhou, D, Guo, J, Gu, S, He, M, Ahmed, S, Hu, J, Qu, W, Li, H (2012). Localization of cerebral functional deficits in patients with obsessive–compulsive disorder: a resting-state fMRI study. Journal of Affective Disorders 138, 313–321.Google Scholar
Inouye, E (1965). Similar and dissimilar manifestations of obsessive–compulsive neuroses in monozygotic twins. American Journal of Psychiatry 121, 1171–1175.CrossRefGoogle ScholarPubMed
Jang, JH, Kim, JH, Jung, WH, Choi, JS, Jung, MH, Lee, JM, Choi, CH, Kang, DH, Kwon, JS (2010). Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive–compulsive disorder. Neuroscience Letters 474, 158–162.Google Scholar
Mason, MF, Norton, MI, Van Horn, JD, Wegner, DM, Grafton, ST, Macrae, CN (2007). Wandering minds: the default network and stimulus-independent thought. Science 315, 393–395.Google Scholar
Mataix-Cols, D, Wooderson, S, Lawrence, N, Brammer, MJ, Speckens, A, Phillips, ML (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive–compulsive disorder. Archives of General Psychiatry 61, 564–576.CrossRefGoogle ScholarPubMed
Matsumoto, R, Ito, H, Takahashi, H, Ando, T, Fujimura, Y, Nakayama, K, Okubo, Y, Obata, T, Fukui, K, Suhara, T (2010). Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive–compulsive disorder: a voxel-based morphometric study. Psychiatry and Clinical Neurosciences 64, 541–547.CrossRefGoogle ScholarPubMed
Menon, V, Uddin, LQ (2010). Saliency, switching, attention and control: a network model of insula function. Brain Structure and Function 214, 655–667.Google Scholar
Menzies, L, Achard, S, Chamberlain, SR, Fineberg, N, Chen, CH, del Campo, N, Sahakian, BJ, Robbins, TW, Bullmore, E (2007). Neurocognitive endophenotypes of obsessive–compulsive disorder. Brain 130, 3223–3236.Google Scholar
Nestadt, G, Samuels, J, Riddle, M, Bienvenu, OJ 3rd, Liang, KY, LaBuda, M, Walkup, J, Grados, M, Hoehn-Saric, R (2000). A family study of obsessive–compulsive disorder. Archives of General Psychiatry 57, 358–363.Google Scholar
O'Donnell, TJ (1970). New dimensions in legal and ethical concepts for human research. 1. Ethical and legal base lines for professions and community. Fundamental and changing moral concepts. Annals of the New York Academy of Sciences 169, 316–318.Google Scholar
Pauls, DL, Alsobrook, JP 2nd, Goodman, W, Rasmussen, S, Leckman, JF (1995). A family study of obsessive–compulsive disorder. American Journal of Psychiatry 152, 76–84.Google Scholar
Pearson, JM, Heilbronner, SR, Barack, DL, Hayden, BY, Platt, ML (2011). Posterior cingulate cortex: adapting behavior to a changing world. Trends in Cognitive Science 15, 143–151.Google Scholar
Peng, ZW, Yang, WH, Miao, GD, Jing, J, Chan, RC (2011). The Chinese version of the Obsessive–Compulsive Inventory-Revised scale: replication and extension to non-clinical and clinical individuals with OCD symptoms. BMC Psychiatry 11, 129.Google Scholar
Power, JD, Fair, DA, Schlaggar, BL, Petersen, SE (2010). The development of human functional brain networks. Neuron 67, 735–748.Google Scholar
Raichle, ME, MacLeod, AM, Snyder, AZ, Powers, WJ, Gusnard, DA, Shulman, GL (2001). A default mode of brain function. Proceedings of the National Academy of Sciences USA 98, 676–682.CrossRefGoogle ScholarPubMed
Rubia, K, Smith, AB, Brammer, MJ, Toone, B, Taylor, E (2005). Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. American Journal of Psychiatry 162, 1067–1075.CrossRefGoogle ScholarPubMed
Sakai, Y, Narumoto, J, Nishida, S, Nakamae, T, Yamada, K, Nishimura, T, Fukui, K (2010). Corticostriatal functional connectivity in non-medicated patients with obsessive–compulsive disorder. European Psychiatry 26, 463–469.CrossRefGoogle ScholarPubMed
Schacter, DL, Addis, DR, Buckner, RL (2007). Remembering the past to imagine the future: the prospective brain. Nature Reviews Neuroscience 8, 657–661.Google Scholar
Simmonds, DJ, Pekar, JJ, Mostofsky, SH (2008). Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia 46, 224–232.CrossRefGoogle ScholarPubMed
Spielberger, DC (1983). Manual for the State-Trait Anxiety Inventory (STAI). Consulting Psychologists Press: Palo Alto, CA.Google Scholar
Spreen, O, Strauss, E (1991). A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. Oxford University Press: New York.Google Scholar
Stern, ER, Fitzgerald, KD, Welsh, RC, Abelson, JL, Taylor, SF (2012). Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive–compulsive disorder. PLOS ONE 7, e36356.Google Scholar
Tomasi, D, Volkow, ND (2012). Gender differences in brain functional connectivity density. Human Brain Mapping 33, 849–860.Google Scholar
Vincent, JL, Patel, GH, Fox, MD, Snyder, AZ, Baker, JT, Van Essen, DC, Zempel, JM, Snyder, LH, Corbetta, M, Raichle, ME (2007). Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447, 83–86.Google Scholar
Wechsler, D (1981). Wechsler Adult Intelligence Scale-Revised. Psychological Corporation: San Antonio.Google Scholar
Wei, GX, Xu, T, Fan, FM, Dong, HM, Jiang, LL, Li, HJ, Yang, Z, Luo, J, Zuo, XN (2013). Can taichi reshape the brain? A brain morphometry study. PLOS ONE 8, e61038.Google Scholar
Weissman, MM, Bland, RC, Canino, GJ, Greenwald, S, Hwu, HG, Lee, CK, Newman, SC, Oakley-Browne, MA, Rubio-Stipec, M, Wickramaratne, PJ (1994). The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. Journal of Clinical Psychiatry 55 (Suppl.), 5–10.Google Scholar
Yan, C, Liu, D, He, Y, Zou, Q, Zhu, C, Zuo, X, Long, X, Zang, Y (2009). Spontaneous brain activity in the default mode network is sensitive to different resting-state conditions with limited cognitive load. PLoS One 4, e5743.CrossRefGoogle ScholarPubMed
Yan, CG, Cheung, B, Kelly, C, Colcombe, S, Craddock, RC, Di Martino, A, Li, Q, Zuo, XN, Castellanos, FX, Milham, MP (2013). A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics. Neuroimage 76, 183–201.CrossRefGoogle ScholarPubMed
Zuo, XN, Ehmke, R, Mennes, M, Imperati, D, Castellanos, FX, Sporns, O, Milham, MP (2012). Network centrality in the human functional connectome. Cerebral Cortex 22, 1862–1875.Google Scholar
Zuo, XN, Kelly, C, Adelstein, JS, Klein, DF, Castellanos, FX, Milham, MP (2010 a). Reliable intrinsic connectivity networks: test–retest evaluation using ICA and dual regression approach. Neuroimage 49, 2163–2177.Google Scholar
Zuo, XN, Kelly, C, Di Martino, A, Mennes, M, Margulies, DS, Bangaru, S, Grzadzinski, R, Evans, AC, Zang, YF, Castellanos, FX, Milham, MP (2010 b). Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. Journal of Neuroscience 30, 15034–15043.CrossRefGoogle ScholarPubMed
Zuo, XN, Xu, T, Jiang, L, Yang, Z, Cao, XY, He, Y, Zang, YF, Castellanos, FX, Milham, MP (2013). Toward reliable characterization of functional homogeneity in the human brain: preprocessing, scan duration, imaging resolution and computational space. Neuroimage 65, 374–386.Google Scholar
Supplementary material: File

Peng Supplementary Material

Supplementary Material

Download Peng Supplementary Material(File)
File 1.4 MB