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Aetiological overlap between obsessive–compulsive and depressive symptoms: a longitudinal twin study in adolescents and adults

Published online by Cambridge University Press:  07 August 2013

K. Bolhuis
Affiliation:
Department of Child and Adolescent Psychiatry, King's College London, Institute of Psychiatry, London, UK
T. A. McAdams
Affiliation:
Social, Genetic and Developmental Psychiatry Centre, King's College London, Institute of Psychiatry, London, UK
B. Monzani
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, Institute of Psychiatry, London, UK
A. M. Gregory
Affiliation:
Department of Psychology, Goldsmiths, University of London, London, UK
D. Mataix-Cols
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, Institute of Psychiatry, London, UK
A. Stringaris
Affiliation:
Department of Child and Adolescent Psychiatry, King's College London, Institute of Psychiatry, London, UK
T. C. Eley*
Affiliation:
Social, Genetic and Developmental Psychiatry Centre, King's College London, Institute of Psychiatry, London, UK
*
*Address for correspondence: T. C. Eley, Ph.D., The Social, Genetic and Developmental Psychiatry Centre, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AZ, UK. (Email: thalia.eley@kcl.ac.uk)
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Abstract

Background

Depression is commonly co-morbid with obsessive–compulsive disorder (OCD). However, it is unknown whether depression is a functional consequence of OCD or whether these disorders share a common genetic aetiology. This longitudinal twin study compared these two hypotheses.

Method

Data were drawn from a longitudinal sample of adolescent twins and siblings (n = 2651; Genesis 12–19 study) and from a cross-sectional sample of adult twins (n = 4920). The longitudinal phenotypic associations between OCD symptoms (OCS) and depressive symptoms were examined using a cross-lag model. Multivariate twin analyses were performed to explore the genetic and environmental contributions to the cross-sectional and longitudinal relationship between OCS and depressive symptoms.

Results

In the longitudinal phenotypic analyses, OCS at time 1 (wave 2 of the Genesis 12–19 study) predicted depressive symptoms at time 2 (wave 3 of the Genesis 12–19 study) to a similar extent to which depressive symptoms at time 1 predicted OCS at time 2. Cross-sectional twin analyses in both samples indicated that common genetic factors explained 52–65% of the phenotypic correlation between OCS and depressive symptoms. The proportion of the phenotypic correlation due to common non-shared environmental factors was considerably smaller (35%). In the adolescent sample, the longitudinal association between OCS at time 1 and subsequent depressive symptoms was accounted for by the genetic association between OCS and depressive symptoms at time 1. There was no significant environmental association between OCS and later depressive symptoms.

Conclusions

The present findings show that OCS and depressive symptoms co-occur primarily due to shared genetic factors and suggest that genetic, rather than environmental, effects account for the longitudinal relationship between OCS and depressive symptoms.

Type
Original Articles
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - SA
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence . The written permission of Cambridge University Press must be obtained for commercial re-use.
Copyright
Copyright © Cambridge University Press 2013

Introduction

Obsessive–compulsive disorder (OCD) is characterized by distressing intrusive thoughts and time-consuming repetitive rituals. Although rare in very young children, OCD affects approximately 1–3% of the population (Flament et al. Reference Flament, Whitaker, Rapoport, Davies, Berg, Kalikow, Sceery and Shaffer1988; Heyman et al. Reference Heyman, Fombonne, Simmons, Ford, Meltzer and Goodman2001; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010). OCD frequently co-occurs with anxiety, mood, impulse-control and substance use disorders (Heyman et al. Reference Heyman, Mataix-Cols and Fineberg2006; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010). Depressive disorders are highly co-morbid in OCD (Heyman et al. Reference Heyman, Mataix-Cols and Fineberg2006; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010), with rates of depression ranging from 20% to 62% in paediatric samples with OCD (Douglass et al. Reference Douglass, Moffitt, Dar, McGee and Silva1995; Heyman et al. Reference Heyman, Fombonne, Simmons, Ford, Meltzer and Goodman2001; Ivarsson et al. Reference Ivarsson, Melin and Wallin2008) and from 50% to 80% in adult samples with OCD (Rasmussen & Eisen, Reference Rasmussen and Eisen1992; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010). This co-morbidity has been demonstrated in both epidemiological (Douglass et al. Reference Douglass, Moffitt, Dar, McGee and Silva1995; Fireman et al. Reference Fireman, Koran, Leventhal and Jacobson2001; Heyman et al. Reference Heyman, Fombonne, Simmons, Ford, Meltzer and Goodman2001; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010) and clinical samples (Geller et al. Reference Geller, Biederman, Griffin, Jones and Lefkowitz1996; Besiroglu et al. Reference Besiroglu, Uguz, Saglam, Agargun and Cilli2007; Ivarsson et al. Reference Ivarsson, Melin and Wallin2008; Peris et al. Reference Peris, Bergman, Asarnow, Langley, McCracken and Piacentini2010).

The reasons for the strong overlap between OCD and depression remain largely unknown. Two contrasting views regarding the relationship between OCD and depressive symptoms are apparent in the literature. One view is that depressive symptoms arise secondarily to the burden and impairment caused by obsessive–compulsive symptoms (OCS) (Storch et al. Reference Storch, Lewin, Larson, Geffken, Murphy and Geller2012). OCS lead to considerable functional impairment (Storch et al. Reference Storch, Larson, Muroff, Caporino, Geller, Reid, Morgan, Jordan and Murphy2010), familial turmoil (Peris et al. Reference Peris, Bergman, Asarnow, Langley, McCracken and Piacentini2010) and peer problems (Storch et al. Reference Storch, Ledley, Lewin, Murphy, Johns, Goodman and Geffken2006) and, in turn, these factors are known to be associated with depression in their own right. This view is supported by data showing that depressive symptoms are associated with greater OCS severity and functional impairment (Peris et al. Reference Peris, Bergman, Asarnow, Langley, McCracken and Piacentini2010; Storch et al. Reference Storch, Larson, Muroff, Caporino, Geller, Reid, Morgan, Jordan and Murphy2010; Krebs et al. Reference Krebs, Bolhuis, Heyman, Mataix-Cols, Turner and Stringaris2013) and that depressive symptoms improve once OCD is successfully treated (Anholt et al. Reference Anholt, Aderka, van Balkom, Smit, Hermesh, de Haan and van Oppen2011). Furthermore, the prevalence of OCS during depressive episodes is 22–38% in patients with major depressive disorder (Gittleson, Reference Gittleson1966; Kendell & Discipio, Reference Kendell and Discipio1970), a much lower prevalence compared with the high rate of depression in OCD.

The alternative view is that the relationship between OCS and depressive symptoms may be due to genetic overlap. OCD and depression co-aggregate in families (Nestadt et al. Reference Nestadt, Samuels, Riddle, Liang, Bienvenu, Hoehn-Saric, Grados and Cullen2001; Carter et al. Reference Carter, Pollock, Suvak and Pauls2004; Hanna et al. Reference Hanna, Himle, Hanna, Gold and Gillespie2011; Bienvenu et al. Reference Bienvenu, Samuels, Wuyek, Liang, Wang, Grados, Cullen, Riddle, Greenberg, Rasmussen, Fyer, Pinto, Rauch, Pauls, McCracken, Piacentini, Murphy, Knowles and Nestadt2012; Goes et al. Reference Goes, McCusker, Bienvenu, Mackinnon, Mondimore, Schweizer, Depaulo and Potash2012) and it has been suggested that, similar to other anxiety disorders, genetic factors involved in the development of OCD may also be involved with the development of depressive disorders (Hettema, Reference Hettema2008). Indeed, the overlap between anxiety and depression is known to be due to shared genetic, rather than environmental, links, in both paediatric (Kendler et al. Reference Kendler, Gardner and Lichtenstein2008; Zavos et al. Reference Zavos, Rijsdijk and Eley2010) and adult samples (Kendler & Gardner, Reference Kendler and Gardner2011). Given that OCD demonstrates a substantial degree of genetic overlap with other anxiety disorders (Tambs et al. Reference Tambs, Czajkowsky, Roysamb, Neale, Reichborn-Kjennerud, Aggen, Harris, Orstavik and Kendler2009), one might expect that the overlap between OCS and depressive symptoms is also genetic in origin. Such an observation would be consistent with the ‘genetic pleiotropy’ hypothesis whereby generalist genes explain most of the overlap between various disorders while environmental effects explain most of the differences between disorders (Eley, Reference Eley1997; Lahey et al. Reference Lahey, Van Hulle, Singh, Waldman and Rathouz2011). This genetic overlap between OCS and depressive symptoms could explain the overlap between their respective pathomechanisms, as both OCS and depressive symptoms are related to serotonergic brain disturbances and both respond to serotonergic medication (Insel, Reference Insel1982; Zohar & Insel, Reference Zohar and Insel1987).

This study explores the genetic and environmental influences on the overlap between OCS and depressive symptoms across the lifespan using a longitudinal twin study design. We predicted that this overlap would be primarily explained by genetic factors shared by the two phenotypes. If this were correct, we would expect strong genetic correlations between OCS and depressive symptoms in both cross-sectional and longitudinal analyses. The alternative hypothesis, that depressive symptoms arise as a result of the burden of OCS, could be described as an evocative gene–environment correlation, where the genetically influenced behaviour of the individual (i.e. OCS) evokes changes in the environment (e.g. conflict with parents) that in turn influence the likelihood of experiencing depressive symptoms. If this were the true process, we would expect high levels of overlap in the non-shared environmental influences on both OCS and later depressive symptoms (Jaffee & Price, Reference Jaffee and Price2007; Kendler & Baker, Reference Kendler and Baker2007).

Method

Sample

Adolescent twin sample

Data were drawn from the Genesis 12–19 (G1219) study, a longitudinal study of twins and siblings (McAdams et al. Reference McAdams, Gregory, Rowe, Zavos, Barclay, Lau, Maughan and Eley2013). Initially 3640 adolescents participated. The present analyses focused on wave 2 and wave 3 (referred to hereafter as time 1 and 2, respectively), which on average took place 8 (range 0–24 months) and 33 months (range 24–60 months), respectively, after first contact. Data were available from 2651 individuals at time 1 (73% of the original sample) and from 1597 individuals at time 2 (44% of the original sample). The mean age of the sample was 15 years (range 12–21 years) at time 1 and 17 years (range 14–23 years) at time 2. More detailed information about the development and selection of the G1219 sample is available elsewhere (McAdams et al. Reference McAdams, Gregory, Rowe, Zavos, Barclay, Lau, Maughan and Eley2013). Ethical approval for this study was provided by the Research Ethics Committees of the Institute of Psychiatry, King's College London and the South London and Maudsley NHS Trust.

Adult twin sample

Data were drawn from the TwinsUK adult twin registry (www.twinsuk.ac.uk), based at St Thomas' Hospital, London, which consists of a volunteer sample of approximately 10 000 Caucasian adult twins, aged between 16 and 90 years (Moayyeri et al. Reference Moayyeri, Hammond, Hart and Spector2013), ascertained from the general population. One time point was available in this sample. The present analyses focused on female twin pairs only [1319 monozygotic (MZ) pairs and 1141 dizygotic (DZ) pairs], as the relatively small number of male twin pairs (n = 318) and opposite-sex twin pairs (n = 66) did not allow investigation of sex differences. The mean age of the sample was 55 years (range 17–87 years). This study was approved by the St Thomas' Hospital Research Ethics Committee.

Measures

Adolescent sample

In the adolescent sample, OCS were measured with the OCD subscale of the self-reported Spence Children's Anxiety Scale. This six-item scale was found to have a good internal consistency and adequate test–retest reliability (Spence, Reference Spence1998). It has been shown to distinguish OCD cases from healthy controls and correlate well with a standard OCS measure (Whiteside et al. Reference Whiteside, Gryczkowski, Biggs, Fagen and Owusu2012).

Depressive symptoms were rated with the self-reported 13-item Short Mood and Feelings Questionnaire (SMFQ). At time 1, a four-point response format (‘never’ to ‘always’) was used to allow for discrimination at the lower end of the spectrum. The standard three-point scale was used at time 2. The SMFQ has good internal consistency, test–retest stability and correlates well with other measures of depressed mood (Costello & Angold, Reference Costello and Angold1988; Costello et al. Reference Costello, Benjamin, Angold and Silver1991; Angold et al. Reference Angold, Costello, Messer, Pickles, Winder and Silver1995).

Adult sample

In the adult sample, OCS were measured using the Obsessive–Compulsive Inventory-Revised (OCI-R), an 18-item five-point Likert scale. The OCI-R is a widely used measure for OCS and has been found to be a reliable, valid, clinically useful measure that correlates well with other OCS measures (Foa et al. Reference Foa, Huppert, Leiberg, Langner, Kichic, Hajcak and Salkovskis2002; Abramowitz & Deacon, Reference Abramowitz and Deacon2006).

Depressive symptoms were rated using a single-item eight-point measure of depressed mood. The scale correlates strongly (r > 0.70) with the 21-item Beck Depression Inventory and its empirically defined cut-offs have acceptable sensitivity and specificity (McKenzie & Marks, Reference McKenzie and Marks1999).

Statistical analyses

Phenotypic analyses

The cross-sectional associations between OCS and depressive symptoms were analysed using linear regression models corrected for sibling relatedness, performed in Stata version 10 for Windows (StataCorp LP, USA). In the adolescent twin sample, the longitudinal relationship between OCS and depressive symptoms was studied using a cross-lagged model, corrected for sibling relatedness, using MPlus for Windows (Muthén & Muthén, Reference Muthén and Muthén1998).

Genetic analyses

Twin studies compare the phenotypic resemblance of MZ twins, who are 100% genetically identical, and DZ twins, who on average share 50% of their segregating genes. The effects of additive genetic (A), shared environmental (C; environmental factors that make siblings alike) and non-shared environmental (E; environmental factors that make siblings different from one another, plus measurement error) factors on a trait can be estimated by comparing the within-pair correlations between MZ and DZ pairs. Genetic factors are assumed to play a role when MZ twin correlations are higher than DZ twin correlations. Shared environmental effects can be estimated by calculating the similarity between MZ pairs that is not due to genetic factors. Non-shared environmental effects can be calculated by subtracting the MZ correlations from 1.

Twin analyses were performed using the program OpenMx (Boker et al. Reference Boker, Neale, Maes, Wilde, Spiegel, Brick, Spies, Estabrook, Kenny, Bates, Mehta and Fox2011). As is standard practice in quantitative genetic model fitting, residuals were taken prior to model fitting in order to account for the effects of age and sex on OCS and depressive symptoms. Variables in both samples were transformed using the Van der Waerden method to ensure normal distribution (Van der Waerden, Reference Van der Waerden1933). Maximum-likelihood model-fitting analyses were undertaken to estimate the contribution of A, C and E to the association between OCS and depressive symptoms (Neale & Cardon, Reference Neale and Cardon1992). In the adolescent sample, the presence of quantitative sex differences for OCS and depressive symptoms was analysed. These analyses examine whether the extent to which genetic, shared environmental and non-shared environmental factors contribute to the total variance is different for males and females. We also tested for the presence of total variance differences between male and females (a scalar model). Submodels were assessed with χ 2 difference tests and Akaike's information criterion (AIC) to test whether constraining the effects of A, C or both to zero would result in a significant reduction in fit, with lower values indicating a better model fit (Neale & Cardon, Reference Neale and Cardon1992).

Bivariate twin analyses were performed to explore the origins of the cross-sectional relationship between OCS and depressive symptoms in both samples. The proportion of the phenotypic overlap that can be explained through genetic and environmental factors was calculated. The sum of these proportions adds up to 1.

The longitudinal relationship between OCS and depressive symptoms was explored in the adolescent sample. A Cholesky decomposition was chosen, in which covariation between variables in additive genetic (A), shared environmental (C) and non-shared environmental factors (E) was examined (Fig. 1). In this model, analyses were corrected for the cross-sectional relationship between OCS and depressive symptoms at time 1 by ordering the variables in such a way that depressive symptoms at time 1 were placed before OCS scores at time 1 (Fig. 1). A Cholesky decomposition was chosen over a single-factor or cross-lag approach in which, respectively, a single latent factor explains the covariance between variables and where the covariation between variables is decomposed in the contributive effects of A, C and E (Neale & Cardon, Reference Neale and Cardon1992), as it allowed us to test the two opposing hypotheses in a single model. Models were fitted to generate genetic and environmental path estimates between the four variables (Fig. 1).

Fig. 1. Cholesky decomposition for obsessive–compulsive disorder symptoms (OCS) and depressive symptoms at time 1 and time 2 in the adolescent sample. The first factor for additive genetic effects (A) accounts for the genetic variance that is common to all four variables. The second factor accounts for the remaining three variables not accounted for by the first factor, and so on. The last factor accounts for the remaining variance in the final variable that is not shared with any other variable in this model.

As is standard practice in quantitative genetic studies, standardized path estimates were presented in figures, whereas tables showed the standardized squared path estimate which are also referred to at times as variance components. The values of the latter add up to 1.

Results

Demographic characteristics

Online Supplementary Table S1 presents the means, standard deviations and regression coefficients for the effects of sex and age on OCS and depressive symptoms in both samples. Online Supplementary Table S2 presents the within-trait twin correlations of both traits in the two samples. At both time points in the adolescent sample, depressive symptom scores were significantly higher in females than in males, and at time 1, though not at time 2, depressive symptom scores were associated with an older age. In the adolescent sample, OCS scores were unrelated to age or sex. In the adult sample, OCS and depressive symptoms were significantly associated with a younger age.

Phenotypic findings

Cross-sectional associations between OCS and depressive symptoms

In the adolescent sample, OCS were significantly associated with depressive symptoms at both time 1 [β = 0.51, 95% confidence interval (CI) 0.46–0.55, p < 0.001] and time 2 (β = 0.46, 95% CI 0.40–0.52, p < 0.001). This was also true for the adult sample (β = 0.41, 95% CI 0.34–0.48, p < 0.001).

Longitudinal associations between OCS and depressive symptoms

The cross-lag model of the longitudinal associations between OCS and depressive symptoms (Fig. 2) shows that the path coefficient from OCS at time 1 to depressive symptoms at time 2 (β = 0.08, 95% CI 0.02–0.16) is similar to the pathway from depressive symptoms at time 1 to OCS at time 2 (β = 0.07, 95% CI 0.01–0.15). Within-trait longitudinal, and cross-trait within-time pathways were all substantial (range β = 0.39–0.51).

Fig. 2. Cross-lag model of the standardized cross-sectional and longitudinal phenotypic associations between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms in the adolescent twin sample. The longitudinal path coefficients were controlled for the effects of depressive symptoms at time 1 and OCS at time 1, and for sibling relatedness. Values in parentheses are 95% confidence intervals. * p < 0.05, ** p < 0.01.

Genetic findings

Univariate analyses of OCS and depressive symptoms

In the adolescent twin sample, scalar sex-limitation models provided the best fit to the data for OCS at time 2 and depressive symptoms at both time points. In these models estimates of genetic and environmental effects were constrained to be the same for males and females. A scalar was included to account for variance differences between the sexes. That is, whilst there was greater variance in female scores, genetic and environmental factors contributed to the variance in OCS and depressive symptoms in the same manner in males and females. A no sex-differences model without a scalar provided the best fit for OCS at time 2. Shared environment effects could be dropped from each of the four models fitted to the adolescent data. In the adult sample, the best fit for OCS was the ACE model, whereas for depressive symptoms this was the AE model. Univariate model-fitting results are reported in online Supplementary Table S3. Additive genetic effects on OCS and depressive symptoms were moderate in both samples (online Supplementary Tables S1 and S2).

Cross-sectional genetic and environmental associations between OCS and depressive symptoms

The genetic and environmental influences on the cross-sectional relationship between OCS and depressive symptoms were analysed using a correlated-factors approach. Bivariate model-fitting analyses are reported in online Supplementary Table S4. An AE model was used for time 2 of the adolescent sample and for the adult sample. An ACE model was used for time 1 of the adolescent sample. In the adolescent sample at time 1, shared environmental factors did not play a significant role on the individual traits, but were significant in the association between traits. In the adult sample the opposite was the case: shared environmental factors had a significant effect on OCS but did not play a significant role in the association between OCS and depressive symptoms. However, overall, shared environmental factors were of marginal influence in both samples and had very limited effects compared with the genetic and non-shared environmental factors. Table 1 shows the cross-sectional phenotypic correlations between OCS and depressive symptoms in both samples. In addition, the proportion of each of these correlations due to genetic, shared environmental and non-shared environmental factors is given. Fig. 3 presents the unsquared standardized path estimates of genetic and environmental influences on the cross-sectional association between OCS and depressive symptoms for the different age groups. It also presents the genetic, shared environmental and non-shared environmental correlations between OCS and depressive symptoms in both samples.

Fig. 3. Standardized unsquared path estimates of additive genetic (A), shared environmental (C) and non-shared environmental (E) factors for the bivariate model of the association between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms for three different age groups (from left to right: time 1 of the adolescent sample; time 2 of the adolescent sample; adult sample). Given are the genetic (r A), shared environmental (r C) and non-shared environmental (r E) correlations between OCS and depressive symptoms. Values in parentheses are 95% confidence intervals.

Table 1. Results from the cross-sectional bivariate correlated-factor models for the cross-sectional association between OCS and depressive symptoms, for all three age groups

OCS, Obsessive–compulsive disorder symptoms; CI, confidence interval.

Fig. 3 demonstrates that for all three age groups (range 12–87 years), OCS and depressive symptoms are highly genetically correlated (range 0.71–0.86). Table 1 shows that these genetic correlations between OCS and depressive symptoms account for a similar proportion of the phenotypic correlation in each of the three age groups (52–65%).

The shared environmental correlation between OCS and depressive symptoms was significant at time 1 in the adolescent sample, although the proportion of the phenotypic correlation explained by the shared environmental correlation was not.

The non-shared environmental correlation between OCS and depressive symptoms was significantly lower than the genetic correlation, and it was similar for the three age groups (range 0.26–0.34). Similarly, the proportion of the phenotypic correlation explained by common non-shared environmental factors was the same for the three age groups (35%).

Longitudinal genetic and environmental associations between OCS and depressive symptoms

The longitudinal genetic relationship between OCS and depressive symptoms was explored in the adolescent sample using a multivariate Cholesky decomposition with four variables. A model of OCS at time 1 predicting later depressive symptoms was fitted, accounting for depressive symptoms at time 1 and OCS at time 2 (Fig. 1). An ACE model with scalars on OCS at time 1 and depressive symptoms at both time points provided the best fit (online Supplementary Table S5). Fig. 4 shows the results of the Cholesky decomposition. Fig. 4 a shows the additive genetic factors that explain the longitudinal association between OCS and depressive symptoms. Fig. 4 b, c shows to what extent the longitudinal association between OCS and depressive symptoms can be explained by overlap in shared and non-shared environmental factors, respectively.

Fig. 4. Results from the Cholesky decomposition examining the longitudinal associations between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms in the adolescent sample. The values presented are the standardized unsquared path estimates, with 95% confidence intervals in parentheses. (a) Associations between additive genetic factors (A) between the two traits. (b) Associations between shared environmental factors (C) between the two traits. (c) Path estimates of non-shared environmental factors (E).

Fig. 4 demonstrates that the genetic factors that account for depressive symptoms at time 1 also account for most of the genetic variance in subsequent depressive symptoms, and about half of the genetic variance in OCS at both time points. Similar to the cross-sectional twin modelling results, there was significant genetic overlap between OCS and depressive symptoms at time 1. After accounting for genetic variance shared with depressive symptoms at time 1, the residual genetic variance in OCS at time 1 was not shared with depressive symptoms at time 2, but did account for some of the variance in OCS at time 2.

Shared environmental factors had a significant effect on OCS at time 1 only. Non-shared environmental effects were largely trait-specific and time-specific, meaning that little of these effects were shared between variables. Specifically, after accounting for that shared with depressive symptoms at time 1, there was no significant overlap in non-shared environmental effects between OCS at time 1 and depressive symptoms at time 2.

Discussion

The present study tested two alternative hypotheses regarding the overlap between OCS and depressive symptoms. The first hypothesis was that depressive symptoms arise as a result of the burden associated with OCS. The second hypothesis was that the overlap between OCS and depressive symptoms could be explained by shared genetic factors. This study found support for the latter hypothesis. Each of the findings is discussed in turn.

The phenotypic results showed that OCS predicted later depressive symptoms to the same extent that depressive symptoms predicted later OCS. Univariate twin analyses demonstrated that OCS and depressive symptoms were moderately heritable in both adolescents and adults. The cross-sectional twin analyses showed that the genetic correlations between OCS and depressive symptoms were similarly high in both adolescents and adults. In the longitudinal twin analyses, the genetic and environmental factors associated with OCS at time 1 did not have a significant effect on later depressive symptoms, after controlling for the effects of depressive symptoms at time 1.

Consistent with previous studies in epidemiological and treatment-seeking samples of adults (Fireman et al. Reference Fireman, Koran, Leventhal and Jacobson2001; Besiroglu et al. Reference Besiroglu, Uguz, Saglam, Agargun and Cilli2007; Ruscio et al. Reference Ruscio, Stein, Chiu and Kessler2010) and young people (Douglass et al. Reference Douglass, Moffitt, Dar, McGee and Silva1995; Geller et al. Reference Geller, Biederman, Griffin, Jones and Lefkowitz1996; Heyman et al. Reference Heyman, Fombonne, Simmons, Ford, Meltzer and Goodman2001), the present results showed a strong cross-sectional phenotypic relationship between OCS and depressive symptoms. The cross-sectional correlations between OCS and depressive symptoms were not identical from time 1 to time 2 in the adolescent sample, suggesting a weakening in their phenotypic associations over time. The within-trait across-time paths of OCS and depressive symptoms were far from 1 (0.48 and 0.44, respectively), which also suggested change over time for both traits. Longitudinal cross-lag model results showed that the significant relationship between OCS and depressive symptoms was of similar magnitude in both directions. This is similar to previous studies that demonstrated that the relationship between anxiety and depression was bi-directional (Moffitt et al. Reference Moffitt, Harrington, Caspi, Kim-Cohen, Goldberg, Gregory and Poulton2007; Zavos et al. Reference Zavos, Rijsdijk and Eley2012). To our knowledge this is the first study to demonstrate the bi-directionality of OCS and depressive symptoms.

Replicating previous studies, OCS and depressive symptoms were moderately heritable in both adolescents and adults (Kendler & Gardner, Reference Kendler and Gardner2011; Taylor, Reference Taylor2011; Zavos et al. Reference Zavos, Rijsdijk and Eley2012). With regard to the view that depressive symptoms are a functional consequence of OCS, the longitudinal analyses showed that there was no significant overlap in non-shared environmental factors between OCS and later depressive symptoms. This implies that the mechanism of evocative gene–environment correlation, where the genetically influenced behaviour of the individual (i.e. OCS) influences the likelihood of experiencing depressive symptoms (Jaffee & Price, Reference Jaffee and Price2007; Kendler & Baker, Reference Kendler and Baker2007), did not hold for the relationship between OCS and later depressive symptoms. This argues against the commonly held view that depressive symptoms arise secondarily to the burden caused by OCS (Peris et al. Reference Peris, Bergman, Asarnow, Langley, McCracken and Piacentini2010; Storch et al. Reference Storch, Larson, Muroff, Caporino, Geller, Reid, Morgan, Jordan and Murphy2010, Reference Storch, Lewin, Larson, Geffken, Murphy and Geller2012; Anholt et al. Reference Anholt, Aderka, van Balkom, Smit, Hermesh, de Haan and van Oppen2011).

Instead, this study found support for the hypothesis that the strong association between OCS and depressive symptoms was explained through shared genetic factors. The cross-sectional twin analyses demonstrated a strong genetic correlation between OCS and depressive symptoms that was similar for adolescents and adults. The cross-sectional non-shared environmental correlations were far lower. Each phenotype seemed to have trait-specific environmental risks. This is consistent with studies showing that OCD and major depressive disorder co-aggregate in families (Nestadt et al. Reference Nestadt, Samuels, Riddle, Liang, Bienvenu, Hoehn-Saric, Grados and Cullen2001; Carter et al. Reference Carter, Pollock, Suvak and Pauls2004, Hanna et al. Reference Hanna, Himle, Hanna, Gold and Gillespie2011; Bienvenu et al. Reference Bienvenu, Samuels, Wuyek, Liang, Wang, Grados, Cullen, Riddle, Greenberg, Rasmussen, Fyer, Pinto, Rauch, Pauls, McCracken, Piacentini, Murphy, Knowles and Nestadt2012; Goes et al. Reference Goes, McCusker, Bienvenu, Mackinnon, Mondimore, Schweizer, Depaulo and Potash2012) and suggests that the association between OCS and depressive symptoms is largely the result of genetic, rather than environmental, overlap. These results are similar to previous findings showing high genetic associations between anxiety and depression (Hettema, Reference Hettema2008; Kendler et al. Reference Kendler, Gardner and Lichtenstein2008; Kendler & Gardner, Reference Kendler and Gardner2011; Zavos et al. Reference Zavos, Rijsdijk and Eley2012). Similar to other anxiety disorders, OCD may share certain personality traits with depression (e.g. neuroticism and negative affect), possibly explaining their phenotypic and genetic relationship (Hettema, Reference Hettema2008). However, there were also genetic effects unique to each of the phenotypes, a finding that has implications for future gene-searching efforts.

The longitudinal twin analyses showed that the relationship between OCS and later depressive symptoms was largely explained through their cross-sectional shared genetic factors. This is consistent with the hypothesis of genetic pleiotropy, whereby generalist genes largely explain the overlap between psychopathologies and environmental exposures primarily explain their differences (Eley, Reference Eley1997; Lahey et al. Reference Lahey, Van Hulle, Singh, Waldman and Rathouz2011).

These findings are clinically important, as many patients presenting with OCS will also suffer from depressive symptoms, and vice versa. These findings showed that depressive symptoms should not be seen as a mere functional consequence of OCS; rather, the association was due to shared genetic effects. It is unclear what these shared effects might be, although they could represent heritable personality traits or cognitive styles (Lau et al. Reference Lau, Rijsdijk and Eley2006; Hettema, Reference Hettema2008). These shared genetic risks might prove useful as potential targets for clinical interventions; indeed some of the existing therapies in the form of cognitive-behaviour therapy may be targeting such shared mechanisms (Zohar & Insel, Reference Zohar and Insel1987; Anholt et al. Reference Anholt, Aderka, van Balkom, Smit, Hermesh, de Haan and van Oppen2011). Future research could focus on identifying such underlying mechanisms and investigating how they might be translated into treatment targets.

This study had a number of methodological strengths, such as the combined use of cross-sectional and longitudinal analyses and replication in two separate samples of different ages. There were also limitations. First, both OCS and depressive symptoms were investigated using different measures in the adolescent and adult samples, and their scores may as such measure slightly different constructs. However, the individual measures have been validated, which suggests that they were able adequately to capture the two phenotypes of OCS and depressive symptoms. Second, there was substantial attrition at follow-up in the adolescent sample. However, although attrition bias might complicate the estimation of trait prevalences, it is unlikely to affect the estimation of between-trait associations (Wolke et al. Reference Wolke, Waylen, Samara, Steer, Goodman, Ford and Lamberts2009). Third, there were small differences in the univariate estimates of the genetic and environmental effects on OCS between those found in the adult analyses and those reported elsewhere using the same sample (Iervolino et al. Reference Iervolino, Rijsdijk, Cherkas, Fullana and Mataix-Cols2011; Monzani et al. Reference Monzani, Rijsdijk, Iervolino, Anson, Cherkas and Mataix-Cols2012). This is probably due to different approaches to the data, as the present study used transformed continuous data and the previous studies used categorized data. However, this does not translate into meaningful differences in terms of interpretation of the hypotheses, and analyses using categorized data lead to identical conclusions (data available upon request). Fourth, since only one time point of data was available, it was not possible to study the genetic and environmental influences on the longitudinal relationship between OCS and depressive symptoms in adults. However, our cross-sectional analyses showed that the genetic correlation between OCS and depressive symptoms was similar for adolescents and adults.

These limitations notwithstanding, this is the first study to examine the genetic and environmental influences on both the cross-sectional and longitudinal relationship between OCS and depressive symptoms in adolescent and adult samples. The finding that OCS and depressive symptoms tend to co-occur primarily due to shared genetic factors offers a good explanation for the high co-morbidity between these disorders and also the fact that both disorders respond to similar pharmacological treatments. Future studies might focus on the mechanisms that underlie this genetic association between OCD and depressive symptoms, and use this knowledge to develop better treatments for these disabling disorders.

Supplementary material

For supplementary material accompanying this paper visit http://dx.doi.org/10.1017/S0033291713001591.

Acknowledgements

We thank the people and staff involved with the G1219 project and the Department of Twin Research (DTR) for their help and support in undertaking this project. Waves 1–3 of the G1219 study were supported by the W T Grant Foundation, the University of London Central Research Fund and a Medical Research Council Training Fellowship and Career Development Award (to T.C.E.). The DTR received support from the Wellcome Trust and the Department of Health via the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London. A.S. acknowledges the support of the Wellcome Trust. T.A.M. acknowledges the support of the Leverhulme Trust (RPG-210).

Declaration of Interest

None.

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Figure 0

Fig. 1. Cholesky decomposition for obsessive–compulsive disorder symptoms (OCS) and depressive symptoms at time 1 and time 2 in the adolescent sample. The first factor for additive genetic effects (A) accounts for the genetic variance that is common to all four variables. The second factor accounts for the remaining three variables not accounted for by the first factor, and so on. The last factor accounts for the remaining variance in the final variable that is not shared with any other variable in this model.

Figure 1

Fig. 2. Cross-lag model of the standardized cross-sectional and longitudinal phenotypic associations between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms in the adolescent twin sample. The longitudinal path coefficients were controlled for the effects of depressive symptoms at time 1 and OCS at time 1, and for sibling relatedness. Values in parentheses are 95% confidence intervals. * p < 0.05, ** p < 0.01.

Figure 2

Fig. 3. Standardized unsquared path estimates of additive genetic (A), shared environmental (C) and non-shared environmental (E) factors for the bivariate model of the association between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms for three different age groups (from left to right: time 1 of the adolescent sample; time 2 of the adolescent sample; adult sample). Given are the genetic (rA), shared environmental (rC) and non-shared environmental (rE) correlations between OCS and depressive symptoms. Values in parentheses are 95% confidence intervals.

Figure 3

Table 1. Results from the cross-sectional bivariate correlated-factor models for the cross-sectional association between OCS and depressive symptoms, for all three age groups

Figure 4

Fig. 4. Results from the Cholesky decomposition examining the longitudinal associations between obsessive–compulsive disorder symptoms (OCS) and depressive symptoms in the adolescent sample. The values presented are the standardized unsquared path estimates, with 95% confidence intervals in parentheses. (a) Associations between additive genetic factors (A) between the two traits. (b) Associations between shared environmental factors (C) between the two traits. (c) Path estimates of non-shared environmental factors (E).

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