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“Forgetting to Remember” in Huntington's Disease: A Study of Laboratory, Semi-Naturalistic, and Self-Perceptions of Prospective Memory

Published online by Cambridge University Press:  19 December 2013

Diane R. Nicoll ,
Eva Pirogovsky ,
Steven Paul Woods ,
Heather M. Holden ,
J. Vincent Filoteo ,
Shea Gluhm ,
Jody Corey-Bloom  and
Paul E. Gilbert
Diane R. Nicoll
Affiliation:
Department of Psychology, San Diego State University, San Diego, California
Eva Pirogovsky
Affiliation:
Veterans Affairs, San Diego Health Care System, San Diego, California Department of Psychiatry, University of California San Diego, La Jolla, California
Steven Paul Woods
Affiliation:
Department of Psychiatry, University of California San Diego, La Jolla, California
Heather M. Holden
Affiliation:
San Diego State University - University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California
J. Vincent Filoteo
Affiliation:
Veterans Affairs, San Diego Health Care System, San Diego, California Department of Psychiatry, University of California San Diego, La Jolla, California
Shea Gluhm
Affiliation:
Department of Neuroscience, University of California San Diego, La Jolla, California
Jody Corey-Bloom
Affiliation:
Department of Neuroscience, University of California San Diego, La Jolla, California
Paul E. Gilbert*
Affiliation:
Department of Psychology, San Diego State University, San Diego, California San Diego State University - University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California
*
Correspondence and reprint requests to: Paul Gilbert, SDSU-UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120. E-mail: pgilbert@mail.sdsu.edu.
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Abstract

Prospective memory (PM) is dependent on executive processes known to be impaired in Huntington's disease (HD); however, no study to the authors’ knowledge has investigated PM in this group. We examined performance-based, semi-naturalistic, and self-reported PM in 20 individuals diagnosed with mild–moderate HD and 20 demographically similar controls. Relative to controls, HD participants demonstrated significantly lower scores in time-based PM, event-based PM (at a trend level), and the semi-naturalistic PM trial, all of which were marked by omission errors. HD participants demonstrated comparable recognition memory for the PM intentions relative to controls. HD and control participants also showed comparable scores in self-reported PM complaints. The results suggest that HD is associated with deficits in the strategic aspects of PM. HD-associated PM deficits also are evident in real-world situations, which may relate to an apparent meta-memory deficit for PM functioning as indicated by HD participants’ overestimation of their PM performance on self-report. (JINS, 2014, 20, 1–8)

Keywords

Episodic memoryMovement disordersMeta-memoryExecutive functionFrontal lobeSelf-report
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 2 , February 2014 , pp. 192 - 199
Copyright
Copyright © The International Neuropsychological Society 2013 

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