Parasitology

  • Parasitology / Volume 141 / Special Issue 01 / January 2014, pp 128-139
  • Copyright © Cambridge University Press 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence <http://creativecommons.org/licenses/by/3.0/>.
  • DOI: http://dx.doi.org/10.1017/S0031182013000826 (About DOI), Published online: 17 July 2013
  • OPEN ACCESS

Research Article

Antimalarial drug discovery – the path towards eradication

JEREMY N BURROWSa1 c1, EMILIE BURLOTa1, BRICE CAMPOa1, STEPHANIE CHERBUINa1, SARAH JEANNERETa1, DIDIER LEROYa1, THOMAS SPANGENBERGa1, DAVID WATERSONa1, TIMOTHY NC WELLSa1 and PAUL WILLISa1

a1 Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois – PO Box 1826, 1215 Geneva 15, Switzerland

SUMMARY

Malaria is a disease that still affects a significant proportion of the global human population. Whilst advances have been made in lowering the numbers of cases and deaths, it is clear that a strategy based solely on disease control year on year, without reducing transmission and ultimately eradicating the parasite, is unsustainable. This article highlights the current mainstay treatments alongside a selection of emerging new clinical molecules from the portfolio of Medicines for Malaria Venture (MMV) and our partners. In each case, the key highlights from each research phase are described to demonstrate how these new potential medicines were discovered. Given the increased focus of the community on eradicating the disease, the strategy for next generation combination medicines that will provide such potential is explained.

(Received March 28 2013)

(Revised May 07 2013)

(Accepted May 07 2013)

(Online publication July 17 2013)

Key words

  • malaria;
  • Plasmodium ;
  • eradication;
  • Target Product Profile;
  • MMV

Correspondence

c1 Corresponding author. Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois – PO Box 1826, 1215 Geneva 15, Switzerland. Tel: +41 22 799 45 70. Fax: +41 22 799 40 61. E-mail: burrowsj@mmv.org

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