British Journal of Nutrition

Full Papers

Behaviour, Appetite and Obesity

Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women

Marina Sancheza1, Christian Darimonta2, Vicky Drapeaua3, Shahram Emady-Azara4, Melissa Lepagea5, Enea Rezzonicoa2, Catherine Ngom-Brua5, Bernard Bergera2, Lionel Philippea4, Corinne Ammon-Zuffreya2, Patricia Leonea2, Genevieve Chevriera6, Emmanuelle St-Amanda6, André Marettea6, Jean Doréa1 and Angelo Tremblaya1 c1

a1 Department of Kinesiology, Faculty of Medicine, Laval University, Quebec, QC, Canada G1V 0A6

a2 Nutrition and Health Research Department, Nestlé Research Center, Lausanne, Switzerland

a3 Department of Physical Education, Faculty of Educational Sciences, Laval University, Quebec, QC, Canada G1V 0A6

a4 Clinical Development Unit, Nestlé Research Center, Lausanne, Switzerland

a5 Analytical Sciences Department, Nestlé Research Center, Lausanne, Switzerland

a6 Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, QC, Canada G1V 4G5

Abstract

The present study investigated the impact of a Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and maintenance in obese men and women over 24 weeks. In a double-blind, placebo-controlled, randomised trial, each subject consumed two capsules per d of either a placebo or a LPR formulation (1·6 × 108 colony-forming units of LPR/capsule with oligofructose and inulin). Each group was submitted to moderate energy restriction for the first 12 weeks followed by 12 weeks of weight maintenance. Body weight and composition were measured at baseline, at week 12 and at week 24. The intention-to-treat analysis showed that after the first 12 weeks and after 24 weeks, mean weight loss was not significantly different between the LPR and placebo groups when all the subjects were considered. However, a significant treatment × sex interaction was observed. The mean weight loss in women in the LPR group was significantly higher than that in women in the placebo group (P= 0·02) after the first 12 weeks, whereas it was similar in men in the two groups (P= 0·53). Women in the LPR group continued to lose body weight and fat mass during the weight-maintenance period, whereas opposite changes were observed in the placebo group. Changes in body weight and fat mass during the weight-maintenance period were similar in men in both the groups. LPR-induced weight loss in women was associated not only with significant reductions in fat mass and circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in faeces. The present study shows that the Lactobacillus rhamnosus CGMCC1.3724 formulation helps obese women to achieve sustainable weight loss.

(Received July 11 2013)

(Revised October 01 2013)

(Accepted October 23 2013)

(Online publication December 03 2013)

Key Words:

  • Energy restriction;
  • Probiotics;
  • Body composition;
  • Microbiota

Correspondence

c1 Corresponding author: A. Tremblay, fax +1 418 656 2441, email angelo.tremblay@kin.ulaval.ca

Footnotes

  Abbreviations: cfu, colony-forming units; LPR, Lactobacillus rhamnosus CGMCC1.3724