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Age Differences in Hippocampus-Cortex Connectivity during True and False Memory Retrieval

Published online by Cambridge University Press:  23 September 2013

Pedro M. Paz-Alonso ,
Pamela Gallego  and
Simona Ghetti
Pedro M. Paz-Alonso*
Affiliation:
Basque Center on Cognition, Brain and Language (BCBL), Donostia-San Sebastián, Gipuzkoa, Spain Center for Mind and Brain, University of California, Davis, California
Pamela Gallego
Affiliation:
Center for Mind and Brain, University of California, Davis, California
Simona Ghetti
Affiliation:
Center for Mind and Brain, University of California, Davis, California Department of Psychology, University of California, Davis, California
*
Correspondence and reprint requests to: Pedro M. Paz-Alonso, BCBL, Paseo Mikeletegi 69, 2, Donostia-San Sebastián, 20009, Gipuzkoa, Spain. E-mail: p.pazalonso@bcbl.eu
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Abstract

The present functional magnetic resonance imaging (fMRI) study investigated developmental differences in functional connectivity associated with true and false memory retrieval. A sample of 8- to 9-year-olds and adults (N = 31) was assessed with the Deese/Roediger-McDermott (DRM) paradigm, known to induce high levels of false recognition of lures that are semantically associated with studied items. The strength of semantic association among list items was manipulated. Relative to children, adults correctly recognized more studied items and falsely recognized more critical lures. High-association lists resulted in higher recognition of both studied items and critical lures. Functional connectivity analysis revealed that, overall, true recognition was supported by coupling within two hippocampal-temporal and fronto-parietal set of regions; in contrast, coupling among more distributed hippocampal-temporal-parietal-frontal regions was observed during false recognition. Critically, adults, compared to children, exhibited stronger hippocampal/parietal coupling and stronger hippocampal/dorsolateral prefrontal cortex (PFC) coupling for veridical recognition of high-associative strength items. In contrast, children, compared to adults, exhibited stronger hippocampus/ventrolateral PFC coupling and stronger bilateral middle-temporal gyrus/ventrolateral PFC coupling for high-associative strength critical lures. Our results underscored a role for the anterior hippocampus in true and false recognition, showing different functional patterns as a function of age and association strength. (JINS, 2013, 19, 1–11)

Keywords

Episodic memoryRecognitionHippocampusMiddle-temporal gyrusPrefrontal cortexFunctional connectivity
Type
Symposia
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 10 , November 2013 , pp. 1031 - 1041
Copyright
Copyright © The International Neuropsychological Society 2013 

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