Journal of Developmental Origins of Health and Disease

Original Article

Insulin-like growth factor-1 and lipoprotein profile in cord blood of preterm small for gestational age infants

N. Naganoa1, T. Okadaa1 c1, R. Fukamachia1, K. Yoshikawaa1, S. Munakataa1, Y. Usukuraa1, S. Hosonoa1, S. Takahashia1, H. Mugishimaa1, M. Matsuuraa2 and T. Yamamotoa2

a1 Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan

a2 Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan


Low birth weight was associated with cardiometabolic diseases in adult age. Insulin-like growth factor-1 (IGF-1) has a crucial role in fetal growth and also associates with cardiometabolic risks in adults. Therefore, we elucidated the association between IGF-1 level and serum lipids in cord blood of preterm infants. The subjects were 41 consecutive, healthy preterm neonates (27 male, 14 female) born at <37-week gestational age, including 10 small for gestational age (SGA) infants (<10th percentile). IGF-1 levels and serum lipids were measured in cord blood, and high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and very low-density lipoprotein triglyceride (VLDLTG) levels were determined by HPLC method. SGA infants had lower IGF-1 (13.1 ± 5.3 ng/ml), total cholesterol (TC) (55.0 ± 14.8), LDLC (21.6 ± 8.3) and HDLC (26.3 ± 11.3) levels, and higher VLDLTG levels (19.0 ± 12.7 mg/dl) than in appropriate for gestational age (AGA) infants (53.6 ± 25.6, 83.4 ± 18.9, 36.6 ± 11.1, 38.5 ± 11.6, 8.1 ± 7.0, respectively). In simple regression analyses, log IGF-1 correlated positively with birth weight (r = 0.721, P < 0.001), TC (r = 0.636, P < 0.001), LDLC (r = 0.453, P = 0.006), and HDLC levels (r = 0.648, P < 0.001), and negatively with log TG (r = −0.484, P = 0.002) and log VLDL-TG (r = −0.393, P = 0.018). Multiple regression analyses demonstrated that IGF-1 was an independent predictor of TC, HDLC and TG levels after the gestational age and birth weight were taken into account. In preterm SGA infants, cord blood lipids profile altered with the concomitant decrease in IGF-1 level.

(Received March 03 2013)

(Revised July 11 2013)

(Accepted July 22 2013)

(Online publication August 28 2013)

Key words

  • high-density lipoprotein;
  • insulin-like growth factor-1;
  • neonate


c1 Address for correspondence: T. Okada MD, Department of Pediatrics and Child Health, Nihon University School of Medicine30-1 Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan. (Email