Acta Neuropsychiatrica

Research Article

A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

Shiguo Liua1a2a3*, Yanhui Liua4*, Yingying Yina4*, Xinhua Zhanga4 c1 and Xu Maa5a6a7 c2

a1 Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China

a2 Institute of Clinical Research, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China

a3 Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China

a4 Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China

a5 Graduate school, Peking Union Medical College, Beijing, China

a6 National Research Institute for Family Planning, Beijing, China

a7 World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.

Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.

Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls ( X 2 = 2.12, df = 2, P = 0.35 by genotype; X 2 = 0.005, df = 1, P = 0.94 by allele).

Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

Keywords

  • interleukin-12;
  • obsessive-compulsive disorder;
  • polymorphism

Correspondence

c1 Xinhua Zhang, MD, Department of psychiatry, Medical College, Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Tel: +86 053282912012; Fax: +86 053282912016; E-mail: xhzhang87@126.com

c2 Professor Xu Ma, Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081 China. Tel: +86 10 62176870; Fax: +86 10 62179151; E-mail: genetic@263.net.cn

Footnotes

* All the three authors contributed equally to this work.