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Mechanism of action of dextromethorphan/quinidine: comparison with ketamine

Published online by Cambridge University Press:  20 September 2013

Stephen M. Stahl
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Abstract

ISSUE:Reports of rapid-onset but short-duration antidepressant effects in patients with treatment-resistant mood disorders after intravenous administration of ketamine have prompted efforts to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action. One candidate for this is dextromethorphan, and here the pharmacologic mechanism of action is compared and contrasted with that of ketamine.

Type
Brainstorms
Information
CNS Spectrums , Volume 18 , Issue 5 , October 2013 , pp. 225 - 227
Copyright
Copyright © Cambridge University Press 2013 

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