Cardiology in the Young

Review Articles

MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle

Ahmed Omrana1a2, Dalia Elimama1, Keith A. Webstera3, Lina A. Shehadeha4 and Fei Yina2 c1

a1 Department of Pediatrics and Neonatology, Suez Canal University, Ismailia, Egypt

a2 Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan, China

a3 Vascular Biology Institute, Department of Molecular and Cellular Pharmacology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America

a4 Interdisciplinary Stem Cell Institute, Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, United States of America

Abstract

Cardiovascular diseases in children comprise a large public health problem. The major goals of paediatric cardiologists and paediatric cardiovascular researchers are to identify the cause(s) of these diseases to improve treatment and preventive protocols. Recent studies show the involvement of microRNAs (miRs) in different aspects of heart development, function, and disease. Therefore, miR-based research in paediatric cardiovascular disorders is crucial for a better understanding of the underlying pathogenesis of the disease, and unravelling novel, efficient, preventive, and therapeutic means. The ultimate goal of such research is to secure normal cardiac development and hence decrease disabilities, improve clinical outcomes, and decrease the morbidity and mortality among children. This review focuses on the role of miRs in different paediatric cardiovascular conditions in an effort to encourage miR-based research in paediatric cardiovascular disorders.

(Received December 06 2012)

(Accepted January 09 2013)

(Online publication February 26 2013)

Keywords

  • MicroRNAs;
  • paediatric cardiovascular diseases;
  • biomarker;
  • therapeutic target;
  • cardiac stem cells

Correspondence

c1 Correspondence to: Dr F. Yin, MD, PhD, Department of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, China. Tel: +86-13517492323; Fax: +86-731-84327922; E-mail: Yf_2323@yahoo.com