a1 Centre for Health Research and Development, Society for Applied Studies, New Delhi, India
a2 Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, Gurgaon, India
a3 National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
In India, rotavirus infections cause the death of 98621 children each year. In urban neighbourhoods in Delhi, children were followed up for 1 year to estimate the incidence of rotavirus gastroenteritis and common genotypes. Infants aged ≤1 week were enrolled in cohort 1 and infants aged 12 months (up to +14 days) in cohort 2. Fourteen percent (30/210) gastroenteritis episodes were positive for rotavirus. Incidence rates of rotavirus gastroenteritis episodes in the first and second year were 0·18 [95% confidence interval (CI) 0·10–0·27] and 0·14 (95% CI 0·07–0·21) episodes/child-year, respectively. The incidence rate of severe rotavirus gastroenteritis in the first year of life was 0·05 (95% CI 0·01–0·10) episodes/child-year. There were no cases in the second year. The common genotypes detected were G1P (27%) and G9P (23%). That severe rotavirus gastroenteritis is common in the first year of life is relevant for planning efficacy trials.
(Received May 02 2012)
(Revised October 11 2012)
(Accepted November 12 2012)
(Online publication January 08 2013)