MRS Bulletin

Surface-enhanced Raman spectroscopy: Substrates and materials

Surface-enhanced Raman spectroscopy: Substrates and materials

Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

Jesse V. Jokersta1, Christoph Pohlinga2 and Sanjiv S. Gambhira3

a1 Molecular Imaging Program, Stanford University; jokerst@stanford.edu

a2 Molecular Imaging Program, Stanford University; pohling@stanford.edu

a3 Molecular Imaging Program, Stanford University; sgambhir@stanford.edu

Abstract

Molecular imaging scans cellular and molecular targets in living subjects through the introduction of imaging agents that bind to these targets and report their presence through a measurable signal. The picomolar sensitivity, signal stability, and high multiplexing capacity of Raman spectroscopy satisfies important needs within the field of molecular imaging, and several groups now utilize Raman and surface-enhanced Raman spectroscopy to image molecular targets in small animal models of human disease. This article details the role of Raman spectroscopy in molecular imaging, describes some substrates and imaging agents used in animal models, and illustrates some examples.

Key Words:

  • Contrast agent;
  • molecular imaging;
  • nanoparticle;
  • Raman spectroscopy;
  • SERS
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