Epidemiology and Infection

Vaccines

Impact of Haemophilus influenzae type b vaccination on the incidence of invasive Haemophilus influenzae disease in France, 15 years after its introduction

S. GEORGESa1, A. LEPOUTREa1, H. DABERNATa2 and D. LEVY-BRUHLa1 c1

a1 Institut de Veille Sanitaire, Saint Maurice, France

a2 Laboratoire de Bactériologie, Faculté de Médecine, Laboratoire AMIS – Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288, CNRS/Université Paul Sabatier, Toulouse, France

SUMMARY

We assessed the impact of Haemophilus influenzae type b (Hib) vaccination, introduced in France in early 1993, on the incidence of invasive Haemophilus influenzae (Hi) disease up to 2008. The incidence of Hi meningitis fell from 0·9/100 000 in 1991–1992 to 0·09/100 000 in 1996–2008, with a marked decline (96%) in children aged <5 years, including infants aged <3 months, from 12 to 0·4/100 000. The incidence of invasive Hi disease also decreased in children aged <15 years from 6 to 0·7/100 000, remained stable in the 15–64 years age group at about 0·5/100 000, and increased slightly from 2·0 to 2·4/100 000 in persons aged >64 years. No emergence of non-encapsulated or encapsulated non-vaccine serotypes was observed. These findings confirm the major direct impact of Hib vaccination on the incidence of Hi invasive disease in children and the indirect benefit of vaccination for infants too young to be vaccinated.

(Received July 20 2012)

(Revised December 17 2012)

(Accepted January 08 2013)

(Online publication February 21 2013)

Key words

  • Haemophilus influenzae ;
  • epidemiology;
  • meningitis;
  • vaccination;
  • France

Correspondence

c1 Author for correspondence: Dr D. Levy-Bruhl, Institut de Veille Sanitaire, 12 rue du Val d'Osne, 94410, Saint Maurice, France. (Email: d.levybruhl@invs.sante.fr)

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