British Journal of Nutrition

Antithrombic peptides from casein in newborn

Characterization of an antithrombotic peptide from α-casein in newborn plasma after milk ingestion

Beathice Chabancea1, Pierre Jollèsa1, Carmen Izquierdoa1, Elisabeth Mazoyera2, Christine Francouala3, Ludovic Droueta2 and Anne-Marie Fiata1

a1 CNRS URA 1188, Laboratoire des Protéines, Université de Paris V, 45 rue des Saints-Pères, F-75270 Paris Cedex 06, France

a2 Institut des Vaisseaux et du Sang, Hospital Lariboisière, 8 rue Guy Patin, F-75010 Paris, France

a3 Hôpital Saint-Vincent de Paul, 74-82 avenue Denfert Rochereau, F-75674 Paris Cedex 14, France


Bovine and human k-caseinoglycopeptides, two antithrombotic peptides derived from the corresponding k-caseins, were detected in physiologically active concentrations in the plasma of 5-d-old newborn infants after ingestion of cow's-milk-based formula or human milk respectively. It is suggested that these two bioactive peptides are released from milk proteins during digestion.

(Received January 31 1994)

(Revised July 08 1994)

(Accepted July 21 1994)