Twin Research and Human Genetics


Association of Adiponectin Gene Polymorphism With Birth Weight in Korean Neonates

Kyoung Ae Konga1, Young Ju Suha2, Su Jin Choa3, Eun Ae Parka3, Mi Hye Parka4 and Young Ju Kima4 c1

a1 Clinical Trial Center, Ewha Womans University Medical Center, Seoul, South Korea

a2 Department of Clinical Research, School of Medicine, Inha University, Incheon, South Korea

a3 Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, South Korea

a4 Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, South Korea


Adiponectin has been associated with insulin resistance and type 2 diabetes mellitus and possibly fetal growth. Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and the birth sizes. We investigated four SNPs of ADIPOQ (rs182052, rs2241766, rs1501299, and rs266729) and birth height and weight in 237 healthy full-term neonates. The neonates with the rs182052 G allele had a greater birth weight (p = .043 in the dominant model) and a higher ponderal index (p = .028 in the additive model). The rs2241766 G allele was associated with a greater birth weight (p = .016 in the recessive model). In a logistic regression analysis, the homozygotes for the rs182052 G allele and those for the rs2241766 G allele showed a significant association with a greater birth weight above 90 percentile (OR 2.75, 95% CI 1.13–6.70 and OR 5.15, 95% CI 1.66–15.99, respectively). In conclusion, we found an association between rs182052 and rs2241766 and birth weight and ponderal index among healthy neonates and suggested that adiponectin might have some roles in fetal growth.

(Received August 17 2012)

(Accepted September 27 2012)

(Online publication April 03 2013)


  • adiponectin;
  • single nucleotide polymorphism;
  • birth weight