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THE EVIDENCE FOR LATE-ONSET PRE-ECLAMPSIA AS A MATERNOGENIC DISEASE OF PREGNANCY

Published online by Cambridge University Press:  19 March 2013

ENRICO FERRAZZI*
Affiliation:
Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy.
TAMARA STAMPALIJA
Affiliation:
Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy.
JEAN EDGARD AUPONT
Affiliation:
High Risk Maternity, St. Damien Children Hospital, Port-au-Prince, Haiti.
*
Enrico Ferrazzi, Department of Woman, Mother and Neonate, Buzzi Children's Hospital, University Department of Biological and Clinical Sciences, University of Milan, Milan, Italy. Email: enrico.ferrazzi@unimi.it

Extract

It is our opinion that the evidence from epidemiological observations, clinical trials and biological studies is strong enough to support the view of different origin and phenotypes of pre-eclampsia: placental, which usually occurs (but not exclusively) early in pregnancy and is associated with poor early placentation of different severity with subsequent restriction of foetal growth, at different stages of gestation; and maternogenic, which generally occurs late in pregnancy and it is not related to placental insufficiency and foetal growth restriction.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2013

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