British Journal of Nutrition

Research Article

Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme

Richard J. FitzGeralda1 c1 and H. Meisela2

a1 Department of Life Sciences, University of Limerick, Limerick, Ireland

a2 Bundesanstalt für Milchforschung, Institut für Chemie und Physik, Kiel, Germany


Numerous casein and whey protein-derived angiotensin-I-converting enzyme (ACE) inhibitory peptides/hydrolysates have been identified. Clinical trials in hypertensive animals and humans show that these peptides/hydrolysates can bring about a significant reduction in hypertension. These peptides/hydrolysates may be classified as functional food ingredients and nutraceuticals due to their ability to provide health benefits i.e. as functional food ingredients in reducing the risk of developing a disease and as nutraceuticals in the prevention/treatment of disease.


c1 * Corresponding author: R. J. FitzGerald