British Journal of Nutrition

Full Papers

Nutritional Toxicology

Effects of feeding Bt MON810 maize to sows during first gestation and lactation on maternal and offspring health indicators

Maria C. Walsha1, Stefan G. Buzoianua1a2, Gillian E. Gardinera2, Mary C. Reaa3a4, Orla O'Donovana2, R. Paul Rossa3a4 and Peadar G. Lawlora1 c1

a1 Teagasc, Pig Development Department, Animal and Grassland Research and Innovation Centre, Moorepark, Fermoy, County Cork, Republic of Ireland

a2 Department of Chemical and Life Sciences, Waterford Institute of Technology, Waterford, County Waterford, Republic of Ireland

a3 Teagasc, Food Research Centre, Moorepark, Fermoy, County Cork, Republic of Ireland

a4 Alimentary Pharmabiotic Centre, University College Cork, Cork, County Cork, Republic of Ireland

Abstract

A total of twenty-four sows and their offspring were used in a 20-week study to investigate the effects of feeding GM maize on maternal and offspring health. Sows were fed diets containing GM or non-GM maize from service to the end of lactation. GM maize-fed sows were heavier on day 56 of gestation (P< 0·05). Offspring from sows fed GM maize tended to be lighter at weaning (P= 0·08). Sows fed GM maize tended to have decreased serum total protein (P= 0·08), and increased serum creatinine (P< 0·05) and γ-glutamyltransferase activity (P= 0·07) on day 28 of lactation. Serum urea tended to be decreased on day 110 of gestation in GM maize-fed sows (P= 0·10) and in offspring at birth (P= 0·08). Both platelet count (P= 0·07) and mean cell Hb concentration (MCHC; P= 0·05) were decreased on day 110 of gestation in GM maize-fed sows; however, MCHC tended to be increased in offspring at birth (P= 0·08). There was a minimal effect of feeding GM maize to sows during gestation and lactation on maternal and offspring serum biochemistry and haematology at birth and body weight at weaning.

(Received October 05 2011)

(Revised April 13 2012)

(Accepted May 01 2012)

(Online publication July 04 2012)

Key Words:

  • Maize;
  • Cry1Ab (1 epidopteran-active crystalline protein);
  • Cross-generational effects;
  • GM food;
  • Safety

Correspondence

c1 Corresponding author: Dr P. G. Lawlor, fax +353 25 42340, E-mail: peadar.lawlor@teagasc.ie

Footnotes

  Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BW, body weight; GGT, γ-glutamyltransferase; Hct, haematocrit; MCHC, mean corpuscular Hb concentration; TP, total protein

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