Epidemiology and Infection

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Original Papers

Trends in annual incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in HIV-infected and HIV-uninfected patients

G. N. DELORENZEa1 c1, M. A. HORBERGa2, M. J. SILVERBERGa1, A. TSAIa1, C. P. QUESENBERRY Jr.a1 and R. BAXTERa3

a1 Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA

a2 Mid-Atlantic Permanente Research Institute, Mid-Atlantic Permanente Medical Group, Rockville, MD, USA

a3 Kaiser Permanente Vaccine Study Center, Oakland, CA, USA

SUMMARY

We describe trends in incidence rates of methicillin-resistant Staphylococcus aureus (MRSA) in HIV-infected and HIV-uninfected patients enrolled in a large northern California Health Plan, and the ratio of MRSA to methicillin-susceptible S. aureus (MSSA) case counts. Between 1995 and 2010, 1549 MRSA infections were diagnosed in 14060 HIV-infected patients (11·0%) compared to 89546 MRSA infections in 6597396 HIV-uninfected patients (1·4%) (P = 0·00). A steady rise in MRSA infection rates began in 1995 in HIV-uninfected patients, peaking at 396·5 infections/100000 person-years in 2007. A more rapid rise in MRSA infection rates occurred in the HIV-infected group after 2000, peaking at 3592·8 infections/100000 in 2005. A declining trend in MRSA rates may have begun in 2008–2009. Comparing the ratio of MRSA to MSSA case counts, we observed that HIV-infected patients shouldered a greater burden of MRSA infection during most years of study follow-up compared to HIV-uninfected patients.

(Received October 11 2012)

(Revised January 16 2013)

(Accepted January 17 2013)

Key words

  • Epidemiology;
  • HIV/AIDS;
  • incidence;
  • methicillin-resistant S;
  • aureus (MRSA)

Correspondence:

c1 Author for correspondence: Dr G. N. DeLorenze, Division of Research, 2000 Broadway, Oakland, CA 94612,. USA (Email: gerald.n.delorenze@kp.org)

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