International Journal of Technology Assessment in Health Care

ASSESSMENTS

BENEFITS OF CONTINUOUS SUBCUTANEOUS INSULIN INFUSION ON QUALITY OF LIFE

Andrea Lukácsa1, Emőke Kiss-Tótha1, Beatrix Vargaa2, Andrea Soósa3, Peter Takáca4 and László Barkaia5

a1 Faculty of Health Care, University of Miskolc

a2 Faculty of Economics, University of Miskolc

a3 Department of Pediatrics, Borsod County University Hospital, Miskolc

a4 Faculty of Health Care, University of Miskolc

a5 Faculty of Health Care, University of Miskolc; Postgraduate Institute of Pediatrics, Medical and Health Science Center, University of Debrecen

Abstract

Purpose: The aim of this study was to compare the general health-related quality of life (HRQoL), the metabolic control (HbA1c), the anthropometric measurement, and the cardiorespiratory fitness (expressed by VO2max) in youths with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) to those receiving multiple daily injections (MDI). We looked for factors influencing the HRQoL and metabolic control.

Methods: A total of 239 patients treated with CSII (51 girls and 53 boys) or MDI (64 girls and 71 boys) between ages 8 and 18 years were assessed with the Pediatric Quality of Life Inventory, Generic Core Scales, and Diabetes Module. VO2max was evaluated using the 20-meter shuttle run test.

Results: CSII group had significantly better HRQoL according to both child self-report and parent proxy-report. Youths with CSII reported better physical, emotional, and school-related functioning, and had less diabetes-related fear and symptoms than the MDI group. There were no significant differences in body mass index z-scores, insulin doses, HbA1c, and VO2max between the groups. HRQoL was predicted by the CSII therapy (β = −0.220; p = .000) and the VO2max (β = 0.386; p = .000), other clinical and anthropometric parameters had no effect; the HbA1c was predicted only by VO2max (β = −0.353; p = .000).

Conclusions: Diabetic youths treated with CSII therapy have better HRQoL than those treated with MDI. There are no differences between the investigated groups in anthropometric data, glycated hemoglobin, and physical fitness. Moreover, good physical fitness has an important role in achieving better metabolic control and HRQoL, which underlines the importance of regular aerobic exercise in the treatment and care of type 1 diabetes in childhood.

Keywords:

  • Type 1 diabetes mellitus;
  • Children;
  • Adolescents;
  • Health-related quality of life;
  • Continuous subcutaneous insulin infusion

Footnotes

  We are very grateful to all diabetes patients and their parents for taking part in this research study. We thank to the physicians and assistants of the summer camps for their interest and co-operation. This research work was carried out as part of the TAMOP-4.2.1.B-10/2/KONV-2010-0001 project with support by the European Union, co-financed by the European Social Fund. Andrea Lukács was granted by the Hungarian Diabetes Association.