Development and Psychopathology

Special Section Articles

Child dopamine active transporter 1 genotype and parenting: Evidence for evocative gene–environment correlations

Elizabeth P. Haydena1 c1, Brigitte Hannaa1, Haroon I. Sheikha1, Rebecca S. Laptooka2, Jiyon Kima2, Shiva M. Singha1 and Daniel N. Kleina2

a1 University of Western Ontario

a2 Stony Brook University

Abstract

The dopamine active transporter 1 (DAT1) gene is implicated in psychopathology risk. Although the processes by which this gene exerts its effects on risk are poorly understood, a small body of research suggests that the DAT1 gene influences early emerging negative emotionality, a marker of children's psychopathology risk. As child negative emotionality evokes negative parenting practices, the DAT1 gene may also play a role in gene–environment correlations. To test this model, children (N = 365) were genotyped for the DAT1 gene and participated in standardized parent–child interaction tasks with their primary caregiver. The DAT1 gene 9-repeat variant was associated with child negative affect expressed toward the parent during parent–child interactions, and parents of children with a 9-repeat allele exhibited more hostility and lower guidance/engagement than parents of children without a 9-repeat allele. These gene–environment associations were partially mediated by child negative affect toward the parent. The findings implicate a specific polymorphism in eliciting negative parenting, suggesting that evocative associations play a role in elevating children's risk for emotional trajectories toward psychopathology risk.

Correspondence:

c1 Address correspondence and reprint requests to: Elizabeth Hayden, Department of Psychology, University of Western Ontario, London, ON N6A 3K7, Canada; E-mail: ehayden@uwo.ca.

Footnotes

  This research was supported by a Young Investigator award from NARSAD and an Early Researcher Award from the Ontario Ministry of Research and Innovation (to E.P.H.), GCRC Grant M01-RR10710 to Stony Brook University from the National Center for Research Resources, and National Institute of Mental Health Grant R01 MH069942 (to D.N.K.). Rebecca S. Laptook is now at the Rhode Island Hospital in the Department of Psychiatry, Division of Child & Adolescent Psychiatry, Providence, Rhode Island.