Twin Research and Human Genetics


The Qingdao Twin Registry: A Status Update

Haiping Duana1 *, Feng Ninga2 *, Dongfeng Zhanga3, Shaojie Wanga1, Dong Zhanga4, Qihua Tana5a6, Xiaocao Tiana1a7 and Zengchang Panga1 c1

a1 Qingdao Centers for Disease Control and Prevention, Qingdao, China

a2 Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland

a3 Department of Public Health, Qingdao University Medical College, Qingdao, China

a4 Jiaonan Centers for Disease Control and Prevention, Qingdao, China

a5 Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark

a6 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

a7 Department of Public Health, University of Shandong, Jinan, China


In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sampled for studying heritability of multiple phenotypes associated with metabolic disorders. In addition, an elderly twin cohort has been recruited with a focus on genetic studies of aging-related phenotypes using twin modeling and genome-wide association analysis. Cross-cultural collaborative studies have been carried out between China, Denmark, Finland, and US cohorts. Ongoing data collection and analysis for the Qingdao Twin Registry will be discussed in this article.

(Received August 31 2012)

(Accepted October 17 2012)

(Online publication November 27 2012)


  • Chinese twins;
  • registry;
  • phenotypes;
  • genome-wide association analysis;
  • cohort study


c1 address for correspondence: Zengchang Pang, Qingdao Centers for Disease Control and Prevention, Shandong Road 175, Sifang District, Qingdao, 266033, P. R. China. Email:


*  These authors contributed equally.