Twin Research and Human Genetics


The North of England Survey of Twin and Multiple Pregnancy

Svetlana V. Glinianaiaa1 c1, Judith Rankina1a2, Stephen N. Sturgissa3, Martin P. Ward Platta2, Danielle Crowdera2 and Ruth Bella1a2 (on behalf of the Northern Survey of Twin and Multiple Pregnancy (NorSTAMP) Steering Group)

a1 Institute of Health & Society, Newcastle University, Newcastle upon Tyne, England, UK

a2 Regional Maternity Survey Office, Newcastle upon Tyne, England, UK

a3 Department of Fetal Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, England, UK


The population-based Northern Survey of Twin and Multiple Pregnancy (NorSTAMP, formerly the Multiple Pregnancy Register) has collected data since 1998 on all multiple pregnancies in North of England (UK) from the earliest point of ascertainment in pregnancy. This paper updates recent developments to the NorSTAMP and presents some early mortality data from the first 10 years of data collection (1998–2007). Since 2005, mothers have been asked to give explicit consent for their identifiable data to be held by the survey, in line with changing guidance and legal frameworks for identifiable data. In 2009, regional standards of care for multiple pregnancies were developed, agreed, and disseminated. During 1998–2007, 4,865 twin maternities (pregnancies with at least one live birth or stillbirth) were registered, with an average twinning rate of 14.9 per 1,000 maternities. The overall stillbirth and neonatal mortality rates in twins were 18.0/1,000 births and 23.0/1,000 live births respectively. Stillbirth and neonatal mortality rates were significantly higher in monochorionic than dichorionic twins: 44.4 versus 12.2 per 1,000 births (relative risk [RR] 3.6, 95% Confidence Intervals [CI] 2.6–5.1), and 32.4 versus 21.4 per 1,000 live births (RR 1.5, 95% CI 1.04–2.2) respectively. There was no significant improvement during this period in either stillbirth or neonatal mortality rates in either chorionicity group. This population-based survey is an important source of data on multiple pregnancies, which allows monitoring of trends in multiple birth rates and pregnancy losses, providing essential information to support improvements in clinical care and for epidemiological research.

(Received August 10 2012)

(Accepted August 14 2012)

(Online publication October 09 2012)


  • twins;
  • multiple pregnancy survey;
  • NorSTAMP;
  • standards of care;
  • chorionicity


c1 address for correspondence: Svetlana V. Glinianaia, Institute of Health & Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK. E-mail: