British Journal of Nutrition

Full Papers

Human and Clinical Nutrition

Effects of lifestyle intervention and meal replacement on glycaemic and body-weight control in Chinese subjects with impaired glucose regulation: a 1-year randomised controlled trial

Dan-Feng Xua1, Jian-Qin Suna1 c1, Min Chena1, Yan-Qiu Chena1, Hua Xiea1, Wei-Jia Suna1, Yi-Fan Lina1, Jing-Jing Jianga1, Wei Suna2, Ai-Fang Chena2 and Qian-Ru Tanga3

a1 Clinical Nutrition Center, Huadong Hospital, Fudan University, No. 221, Yan'an (West) Road, Shanghai 200040, People's Republic of China

a2 Caojiadu Community Health Center, Jing'an District, Shanghai, People's Republic of China

a3 Jing'an Temple Community Health Center, Jing'an District, Shanghai, People's Republic of China

Abstract

The purpose of the present study was to evaluate the impact of a lifestyle intervention programme, combined with a daily low-glycaemic index meal replacement, on body-weight and glycaemic control in subjects with impaired glucose regulation (IGR). Subjects with IGR were randomly assigned to an intervention group (n 46) and a control group (n 42). Both groups received health counselling at baseline. The intervention group also received a daily meal replacement and intensive lifestyle intervention to promote healthy eating habits during the first 3 months of the study, and follow-up visits performed monthly until the end of the 1-year study. Outcome measurements included changes in plasma glucose, glycated Hb (HbA1c), plasma lipids, body weight, blood pressure and body composition (such as body fat mass and visceral fat area). The results showed that body-weight loss after 1 year was significant in the intervention group compared with the control group ( − 1·8 (sem 0·35) v.− 0·6 (sem 0·40) 2·5 kg, P< 0·05). The 2 h plasma glucose concentration decreased 1·24 mmol/l in the intervention group and increased 0·85 mmol/l in the control group (P< 0·05) compared with their baseline, respectively. A 5 kg body-weight loss at 1 year was associated with a decrease of 1·49 mmol/l in 2 h plasma glucose (P< 0·01). The incidence of normal glucose regulation (NGR) in the two groups was significantly different (P= 0·001). In conclusion, the combination of regular contact, lifestyle advice and meal replacement is beneficial in promoting IGR to NGR.

(Received July 01 2011)

(Revised February 24 2012)

(Accepted March 08 2012)

(Online publication July 05 2012)

Key Words:

  • Impaired glucose regulation;
  • Meal replacement;
  • Glycaemic control;
  • Weight loss

Correspondence:

c1 Corresponding author: J.-Q. Sun, fax +86 21 32140503, E-mail: jianqins@gmail.com

Footnotes

  Abbreviations: DPP, Diabetes Prevention Program; DPS, Diabetes Prevention Study; HbA1c, glycated Hb; IGR, impaired glucose regulation; NGR, normal glucose regulation

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